Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type IX, alpha subunit | Starlite/ChEMBL | References |
Homo sapiens | sodium channel, voltage-gated, type V, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein arginine N methyltransferase 7 | 0.0173 | 0.0448 | 0.0448 |
Entamoeba histolytica | hypothetical protein | 0.0173 | 0.0448 | 0.5 |
Leishmania major | arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 | 0.0173 | 0.0448 | 1 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0173 | 0.0448 | 0.5 |
Echinococcus granulosus | methyltransferase protein 5 | 0.0173 | 0.0448 | 0.0448 |
Entamoeba histolytica | arginine N-methyltransferase 1, putative | 0.0173 | 0.0448 | 0.5 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.1919 | 1 | 1 |
Onchocerca volvulus | 0.1747 | 0.9056 | 0.5 | |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.1919 | 1 | 1 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0173 | 0.0448 | 0.5 |
Trypanosoma brucei | protein arginine n-methyltransferase 7 | 0.0173 | 0.0448 | 0.5 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.1919 | 1 | 1 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0173 | 0.0448 | 0.5 |
Trypanosoma cruzi | protein arginine n-methyltransferase 7 | 0.0173 | 0.0448 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0173 | 0.0448 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, type III | 0.0173 | 0.0448 | 0.5 |
Loa Loa (eye worm) | Carm1-pending protein | 0.1919 | 1 | 1 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0173 | 0.0448 | 0.5 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.0173 | 0.0448 | 0.5 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.1919 | 1 | 1 |
Echinococcus granulosus | protein arginine N methyltransferase 7 | 0.0173 | 0.0448 | 0.0448 |
Leishmania major | arginine N-methyltransferase, type I | 0.0173 | 0.0448 | 1 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0173 | 0.0448 | 0.5 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0173 | 0.0448 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0173 | 0.0448 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.33 | Inhibition of Nav1.5 by cell based whole-cell voltage clamp electrophysiology assay | ChEMBL. | 21641215 |
IC50 (binding) | = 6.9 | Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assay | ChEMBL. | 21641215 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.