Detailed information for compound 994527

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 291.385 | Formula: C17H25NO3
  • H donors: 0 H acceptors: 0 LogP: 2.87 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1OCC1OCCN(C1)C1CCC1
  • InChi: 1S/C17H25NO3/c1-2-19-16-8-3-4-9-17(16)21-13-15-12-18(10-11-20-15)14-6-5-7-14/h3-4,8-9,14-15H,2,5-7,10-13H2,1H3
  • InChiKey: ATDVXPMJJCNASN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0185 0.0236
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0081 0.0127
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0837 0.1303
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0811 0.1263
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0345 0.0897
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0185 0.0288
Onchocerca volvulus 0.002 0.0185 0.0171
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0185 0.0288
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0837 0.1303
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0176 0.2636 1
Brugia malayi jmjC domain containing protein 0.0016 0.012 0.0146
Onchocerca volvulus 0.003 0.0345 0.0331
Schistosoma mansoni acetylcholine receptor subunit beta 0.0009 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0398 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.0176 0.2636 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0079
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Loa Loa (eye worm) inositol-1 0.0038 0.046 0.1429
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.046 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Brugia malayi Cation transporter family protein 0.002 0.0185 0.0236
Echinococcus granulosus nAChR subunit 0.0011 0.0039 0.0061
Onchocerca volvulus 0.0028 0.0309 0.0295
Schistosoma mansoni lamin 0.0028 0.0309 0.0482
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0185 0.0236
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0105 0.0289
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0185 0.0288
Schistosoma mansoni nAChR subunit 0.002 0.0185 0.0288
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0318 0.0495
Loa Loa (eye worm) hypothetical protein 0.0016 0.0126 0.0359
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0185 0.0288
Schistosoma mansoni hypothetical protein 0.0173 0.2584 0.4023
Brugia malayi jmjC domain containing protein 0.006 0.0811 0.1103
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.012 0.0187
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0185 0.0236
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0185 0.0236
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0185 0.0547
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.012 0.0187
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.046 0.1354
Echinococcus multilocularis phd:f box containing protein 0.0016 0.012 0.0187
Onchocerca volvulus 0.002 0.0185 0.0171
Schistosoma mansoni nAChR subunit 0.002 0.0185 0.0288
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0684 0.0927
Schistosoma mansoni cpg binding protein 0.0031 0.0355 0.0553
Schistosoma mansoni nAChR subunit 0.0009 0.0015 0.0023
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0185 0.0288
Loa Loa (eye worm) ACC-1 protein 0.002 0.0185 0.0547
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0309 0.0409
Loa Loa (eye worm) hypothetical protein 0.0028 0.0301 0.092
Onchocerca volvulus 0.0237 0.3583 0.3574
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0185 0.0547
Echinococcus granulosus lamin 0.0028 0.0309 0.0482
Echinococcus multilocularis nAChR subunit 0.0011 0.0039 0.0061
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0185 0.0547
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.012 0.0337
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0188
Onchocerca volvulus 0.0011 0.0039 0.0025
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.046 0.0851
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0329 0.1007
Schistosoma mansoni hypothetical protein 0.0417 0.6423 1
Onchocerca volvulus 0.002 0.0185 0.0171
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.046 0.0717
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0345 0.0538
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.017 0.0264
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0079
Schistosoma mansoni nAChR subunit 0.002 0.0185 0.0288
Brugia malayi Pre-SET motif family protein 0.0208 0.3134 0.4321
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.017 0.0215
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0185 0.0288
Schistosoma mansoni inositol monophosphatase 0.0038 0.046 0.0717
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0185 0.0288
Schistosoma mansoni hypothetical protein 0.0173 0.2584 0.4023
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.046 0.0851
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0185 0.0288
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0185 0.0288
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.017 0.0199
Schistosoma mansoni nAChR subunit 0.002 0.0185 0.0288
Schistosoma mansoni hypothetical protein 0.0035 0.0426 0.0663
Onchocerca volvulus Putative nachr subunit 0.002 0.0185 0.0171
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0185 0.0288
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0426 0.057
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.012 0.0337
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0185 0.0288
Schistosoma mansoni inositol monophosphatase 0.0038 0.046 0.0717
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0126 0.0155
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0176 0.2636 1
Echinococcus granulosus phd:f box containing protein 0.0016 0.012 0.0187
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0015 0.0023
Onchocerca volvulus 0.002 0.0185 0.0171
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0079
Trypanosoma brucei telomerase reverse transcriptase 0.0176 0.2636 1
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0185 0.0236
Schistosoma mansoni neurotransmitter gated ion channel 0.0011 0.0039 0.0061
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0811 0.1263
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0079
Echinococcus granulosus dnaJ subfamily B 0.0417 0.6423 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0009 0.0015 0.0023
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0185 0.0288
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0185 0.0288
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0185 0.0288
Schistosoma mansoni cpg binding protein 0.0031 0.0355 0.0553
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0185 0.0236
Echinococcus multilocularis GPCR, family 2 0.0016 0.0126 0.0197
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0185 0.0547
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0185 0.0288
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0837 0.1303
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0185 0.0236
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.012 0.0337
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0126 0.0197
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0684 0.0927
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Echinococcus granulosus GPCR family 2 0.0016 0.0126 0.0197
Schistosoma mansoni acetylcholine receptor-related 0.0009 0.0015 0.0023
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0015 0.0023
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0398 0.5
Brugia malayi Cation transporter family protein 0.002 0.0185 0.0236
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Echinococcus multilocularis cpg binding protein 0.0031 0.0355 0.0553
Toxoplasma gondii exonuclease III APE 0.0019 0.017 0.0199
Schistosoma mansoni ap endonuclease 0.0019 0.017 0.0264
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0185 0.0236
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.017 0.3104
Schistosoma mansoni nAChR subunit 0.002 0.0185 0.0288
Schistosoma mansoni ap endonuclease 0.0019 0.017 0.0264
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0039 0.0034
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0011 0.0039 0.0061
Schistosoma mansoni protein phosphatase 2C 0.0016 0.012 0.0187
Brugia malayi Telomerase reverse transcriptase 0.0469 0.7233 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0009 0.0015 0.0023
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.012 0.0187
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0758 0.2535
Loa Loa (eye worm) hypothetical protein 0.0016 0.012 0.0337
Schistosoma mansoni hypothetical protein 0.0016 0.0126 0.0197
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0126 0.0155
Schistosoma mansoni cpg binding protein 0.0029 0.0329 0.0512
Plasmodium vivax SET domain protein, putative 0.003 0.0345 0.0897
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0185 0.0288
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.046 0.1354
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.017 0.0199
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Giardia lamblia Telomerase catalytic subunit 0.0176 0.2636 1
Brugia malayi jmjC domain containing protein 0.0016 0.012 0.0146
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0011 0.0039 0.0061
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.017 0.0199
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0079
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0079
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0185 0.0236
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0146 0.0227
Echinococcus granulosus geminin 0.0173 0.2584 0.4023
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.017 0.0498
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0081 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0345 0.0538
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.012 0.0187
Brugia malayi Inositol-1 0.0038 0.046 0.0618
Onchocerca volvulus 0.002 0.0185 0.0171
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0309 0.0945
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0185 0.0236
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.046 0.1354
Schistosoma mansoni hypothetical protein 0.0016 0.0126 0.0197
Schistosoma mansoni nAChR subunit 0.002 0.0185 0.0288
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0185 0.0288
Loa Loa (eye worm) hypothetical protein 0.0052 0.0684 0.2145
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0028 0.0044
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.046 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0185 0.0547
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0185 0.0236
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.046 0.0717
Brugia malayi intermediate filament protein 0.0028 0.0309 0.0409
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0079
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0185 0.0288
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0185 0.0288
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.017 0.0199
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0185 0.0288
Brugia malayi jmjC domain containing protein 0.0062 0.0837 0.114
Onchocerca volvulus 0.0011 0.0039 0.0025
Echinococcus multilocularis lamin dm0 0.0028 0.0309 0.0482
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0028 0.0044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.017 0.0199
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0185 0.0236
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.017 0.0199
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0185 0.0288
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0126 0.0359
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0009 0.0015 0.0023
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0039 0.0034
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0185 0.0288
Schistosoma mansoni phd/f-box containing protein 0.0016 0.012 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0345 0.0538
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0345 0.0538
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Schistosoma mansoni hypothetical protein 0.0016 0.0126 0.0197
Brugia malayi jmjC domain containing protein 0.0016 0.012 0.0146
Onchocerca volvulus 0.0028 0.0309 0.0295
Toxoplasma gondii RNA-directed DNA polymerase 0.0176 0.2636 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0011 0.0039 0.0034
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0185 0.0547
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0185 0.0288
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.017 0.0264
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0684 0.2145
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0185 0.0236
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0811 0.1263
Schistosoma mansoni hypothetical protein 0.0016 0.0126 0.0197
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0079
Brugia malayi Pre-SET motif family protein 0.003 0.0345 0.0458
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0345 0.0538
Brugia malayi CXXC zinc finger family protein 0.0029 0.0329 0.0435
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0126 0.0197
Echinococcus multilocularis geminin 0.0173 0.2584 0.4023
Leishmania major telomerase reverse transcriptase, putative 0.0176 0.2636 1
Brugia malayi Cation transporter family protein 0.002 0.0185 0.0236
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0214
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0126 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0345 0.0538
Onchocerca volvulus 0.002 0.0185 0.0171
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.012 0.0187
Echinococcus granulosus nAChR subunit 0.002 0.0185 0.0288
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0009 0.0015 0.0023
Echinococcus multilocularis musashi 0.0028 0.0309 0.0482
Schistosoma mansoni lamin 0.0028 0.0309 0.0482
Loa Loa (eye worm) LGC-31 protein 0.002 0.0185 0.0547
Loa Loa (eye worm) hypothetical protein 0.0035 0.0426 0.1318
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0185 0.0288
Schistosoma mansoni intermediate filament proteins 0.0028 0.0309 0.0482
Schistosoma mansoni nAChR subunit 0.0009 0.0015 0.0023
Plasmodium falciparum telomerase reverse transcriptase 0.0176 0.2636 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.046 0.1354
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.012 0.0187
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.3134 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0185 0.0236
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.046 0.0851
Echinococcus multilocularis nAChR subunit 0.002 0.0185 0.0288
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0185 0.0288
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.012 0.0187
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0185 0.0236
Loa Loa (eye worm) ACC-1 protein 0.002 0.0185 0.0547
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.012 0.0187
Loa Loa (eye worm) hypothetical protein 0.0016 0.012 0.0337
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.6423 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0837 0.2637
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0026 0.0016
Echinococcus granulosus cpg binding protein 0.0031 0.0355 0.0553
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0126 0.0197
Echinococcus granulosus intermediate filament protein 0.0028 0.0309 0.0482
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0185 0.0288
Loa Loa (eye worm) GABA receptor subunit 0.0011 0.0039 0.0079
Schistosoma mansoni nAChR subunit 0.002 0.0185 0.0288
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0009 0.0015 0.0023
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0345 0.0538
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Brugia malayi jmjC domain containing protein 0.0016 0.012 0.0146
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0185 0.0236
Loa Loa (eye worm) hypothetical protein 0.003 0.0345 0.1061
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0105 0.0125
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.046 0.1354
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0185 0.0288
Loa Loa (eye worm) histone methyltransferase 0.001 0.0028 0.0043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0188
Echinococcus multilocularis lamin 0.0028 0.0309 0.0482
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0862 0.1342
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0547
Loa Loa (eye worm) hypothetical protein 0.0016 0.012 0.0337
Schistosoma mansoni jumonji domain containing protein 0.006 0.0811 0.1263
Echinococcus granulosus lamin dm0 0.0028 0.0309 0.0482
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.017 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0079
Trichomonas vaginalis set domain proteins, putative 0.0237 0.3583 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0185 0.0288
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0185 0.0288
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0011 0.0039 0.0034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0309 0.0945
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0185 0.0236
Onchocerca volvulus 0.0029 0.0329 0.0315
Schistosoma mansoni jumonji domain containing protein 0.0016 0.012 0.0187
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0185 0.0288
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.046 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0146 0.0227
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0309 0.0945
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0185 0.0288

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 7100 nM Displacement of [125I]iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells ChEMBL. 18922693

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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