Detailed information for compound 994619

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.378 | Formula: C18H23NO6
  • H donors: 5 H acceptors: 4 LogP: -1.22 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=C2[C@H]3NCC[C@]2(C[C@@H]([C@@H]1O)O)c1c([C@H]3O)ccc(c1O)OC
  • InChi: 1S/C18H23NO6/c1-24-10-4-3-8-11(16(10)23)18-5-6-19-13(14(8)21)12(18)17(25-2)15(22)9(20)7-18/h3-4,9,13-15,19-23H,5-7H2,1-2H3/t9-,13+,14+,15-,18-/m0/s1
  • InChiKey: CQFMGBHPLGTYRE-ZERSTCQWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nAChR subunit 0.00749476 0.0302797 0.0667991
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Onchocerca volvulus 0.0108179 0.0580067 0.129131
Schistosoma mansoni serine/threonine protein kinase 0.0114662 0.0634166 0.139901
Onchocerca volvulus 0.0108179 0.0580067 0.129131
Onchocerca volvulus 0.0108179 0.0580067 0.129131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.0577037 0.449208 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00749476 0.0302797 0.0674068
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.00749476 0.0302797 0.0674068
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.00749476 0.0302797 0.0580815
Schistosoma mansoni nAChR subunit 0.00749476 0.0302797 0.0667991
Brugia malayi G-protein coupled receptor 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00991808 0.0504992 0.111405
Echinococcus granulosus neuropeptide Y receptor 0.0215082 0.147204 0.282361
Schistosoma mansoni opsin-like receptor 0.0215082 0.147204 0.324741
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0215082 0.147204 0.324741
Onchocerca volvulus 0.00457117 0.00588611 0.0131033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Toxoplasma gondii kringle domain-containing protein 0.00457117 0.00588611 0.00588611
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0114662 0.0634166 1
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.00653998 0.0223133 0.0428007
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0215082 0.147204 0.327696
Onchocerca volvulus 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Brugia malayi excitatory GABA receptor EXP-1A 0.00749476 0.0302797 0.0674068
Onchocerca volvulus 0.00749476 0.0302797 0.0674068
Toxoplasma gondii hypothetical protein 0.0108179 0.0580067 0.0580067
Echinococcus granulosus rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Schistosoma mansoni opsin-like receptor 0.0215082 0.147204 0.324741
Echinococcus multilocularis glycine receptor subunit alpha 1 0.00749476 0.0302797 0.0580815
Echinococcus multilocularis glycine receptor subunit alpha 1 0.00749476 0.0302797 0.0580815
Brugia malayi Trypsin family protein 0.00991808 0.0504992 0.112418
Entamoeba histolytica protein kinase domain containing protein 0.0114662 0.0634166 1
Schistosoma mansoni opsin-like receptor 0.0215082 0.147204 0.324741
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00749476 0.0302797 0.0674068
Schistosoma mansoni cercarial elastase (S01 family) 0.00991808 0.0504992 0.111405
Onchocerca volvulus 0.0215082 0.147204 0.327696
Onchocerca volvulus 0.0215082 0.147204 0.327696
Echinococcus granulosus g protein coupled receptor 0.0215082 0.147204 0.282361
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0577037 0.449208 0.990984
Echinococcus granulosus peptide allatostatin:somatostatin 0.0215082 0.147204 0.282361
Echinococcus multilocularis glycine receptor subunit beta 0.00749476 0.0302797 0.0580815
Echinococcus granulosus Mastin 0.00991808 0.0504992 0.0968659
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0110999 0.0603596 0.134369
Toxoplasma gondii microneme protein MIC17C 0.0108179 0.0580067 0.0580067
Schistosoma mansoni hypothetical protein 0.0215082 0.147204 0.324741
Onchocerca volvulus 0.0108179 0.0580067 0.129131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0215082 0.147204 0.324741
Onchocerca volvulus 0.00991808 0.0504992 0.112418
Echinococcus multilocularis integrin alpha 3 0.0132005 0.0778865 0.149399
Echinococcus granulosus transmembrane protease serine 3 0.00991808 0.0504992 0.0968659
Leishmania major hypothetical protein, conserved 0.00457117 0.00588611 0.0126224
Echinococcus granulosus glycine receptor subunit alpha 1 0.00749476 0.0302797 0.0580815
Brugia malayi hypothetical protein 0.0215082 0.147204 0.327696
Brugia malayi serine/threonine-protein kinase 6 0.0114662 0.0634166 0.141174
Brugia malayi Trypsin family protein 0.00991808 0.0504992 0.112418
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.00749476 0.0302797 0.0674068
Schistosoma mansoni protein kinase 0.0114662 0.0634166 0.139901
Brugia malayi bZIP transcription factor family protein 0.0110607 0.0600331 0.133642
Brugia malayi PAN domain containing protein 0.0108179 0.0580067 0.129131
Mycobacterium ulcerans hypothetical protein 0.00991808 0.0504992 0.5
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.00653998 0.0223133 0.0496725
Brugia malayi Cation transporter family protein 0.0148207 0.0914055 0.203481
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus granulosus sodium channel protein 0.0597548 0.466322 0.894484
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.00749476 0.0302797 0.0580815
Loa Loa (eye worm) hypothetical protein 0.0108179 0.0580067 0.129131
Brugia malayi Serotonin receptor 0.0215082 0.147204 0.327696
Onchocerca volvulus 0.0215082 0.147204 0.327696
Onchocerca volvulus 0.0477856 0.366455 0.815779
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00749476 0.0302797 0.0674068
Schistosoma mansoni nAChR subunit 0.00749476 0.0302797 0.0667991
Onchocerca volvulus 0.00991808 0.0504992 0.112418
Echinococcus multilocularis neuropeptide FF receptor 2 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Brugia malayi serine/threonine protein kinase 6 0.0114662 0.0634166 0.141174
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) G-protein coupled receptor 0.0215082 0.147204 0.327696
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.00749476 0.0302797 0.0674068
Echinococcus granulosus tm gpcr rhodopsin 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus granulosus rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus granulosus alpha 1A adrenergic receptor 0.0215082 0.147204 0.282361
Toxoplasma gondii microneme protein MIC17B 0.0108179 0.0580067 0.0580067
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0215082 0.147204 0.324741
Schistosoma mansoni neuropeptide receptor 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.0148207 0.0914055 0.203481
Echinococcus granulosus glycine receptor subunit beta 0.00749476 0.0302797 0.0580815
Echinococcus multilocularis rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Schistosoma mansoni neuropeptide receptor 0.0215082 0.147204 0.324741
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0215082 0.147204 0.324741
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0215082 0.147204 0.282361
Onchocerca volvulus Putative nachr subunit 0.0148207 0.0914055 0.203481
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0148207 0.0914055 0.175331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0215082 0.147204 0.324741
Onchocerca volvulus 0.0108179 0.0580067 0.129131
Trichomonas vaginalis AGC family protein kinase 0.0114662 0.0634166 1
Schistosoma mansoni protein kinase 0.0127773 0.0743555 0.164033
Brugia malayi PAN domain containing protein 0.0108179 0.0580067 0.129131
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Brugia malayi PAN domain containing protein 0.0108179 0.0580067 0.129131
Loa Loa (eye worm) AUR protein kinase 0.0114662 0.0634166 0.141174
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0215082 0.147204 0.324741
Echinococcus multilocularis g protein coupled receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Brugia malayi Melatonin receptor type 1A 0.0215082 0.147204 0.327696
Schistosoma mansoni nAChR subunit 0.00749476 0.0302797 0.0667991
Schistosoma mansoni growth hormone secretagogue receptor 0.0215082 0.147204 0.324741
Brugia malayi G-protein coupled receptor 0.0215082 0.147204 0.327696
Echinococcus granulosus sex peptide receptor 0.0215082 0.147204 0.282361
Brugia malayi phosphoinositide-dependent protein kinase I 0.00653998 0.0223133 0.0496725
Brugia malayi hypothetical protein 0.0215082 0.147204 0.327696
Brugia malayi hypothetical protein 0.00991808 0.0504992 0.112418
Echinococcus granulosus neuropeptide Y receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.00451858 0.00544732 0.0121265
Schistosoma mansoni hypothetical protein 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.00451858 0.00544732 0.0121265
Loa Loa (eye worm) PAN domain-containing protein 0.0108179 0.0580067 0.129131
Echinococcus multilocularis neuropeptide receptor A26 0.0663476 0.521331 1
Schistosoma mansoni protein kinase 0.0127773 0.0743555 0.164033
Brugia malayi PAN domain containing protein 0.0108179 0.0580067 0.129131
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0148207 0.0914055 0.175331
Echinococcus multilocularis somatostatin receptor 0.0215082 0.147204 0.282361
Echinococcus granulosus glycoprotein Antigen 5 0.00991808 0.0504992 0.0968659
Schistosoma mansoni biogenic amine (5HT) receptor 0.0215082 0.147204 0.324741
Echinococcus multilocularis nAChR subunit 0.00749476 0.0302797 0.0580815
Echinococcus multilocularis neuropeptide receptor 0.0215082 0.147204 0.282361
Brugia malayi sulfakinin receptor protein 0.0215082 0.147204 0.327696
Schistosoma mansoni neuropeptide F-like receptor 0.0215082 0.147204 0.324741
Toxoplasma gondii aurora kinase 0.0114662 0.0634166 0.0634166
Onchocerca volvulus 0.0577037 0.449208 1
Echinococcus granulosus jun protein 0.0110607 0.0600331 0.115154
Echinococcus multilocularis neuropeptides capa receptor 0.0215082 0.147204 0.282361
Echinococcus granulosus rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0215082 0.147204 0.282361
Brugia malayi putative neuropeptide receptor NPR1 0.0215082 0.147204 0.327696
Echinococcus multilocularis jumonji domain containing protein 0.00519981 0.0111313 0.0213516
Trichomonas vaginalis AGC family protein kinase 0.00653998 0.0223133 0.351853
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Brugia malayi GnHR receptor homolog 0.0215082 0.147204 0.327696
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0215082 0.147204 0.282361
Onchocerca volvulus 0.0215082 0.147204 0.327696
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.00749476 0.0302797 0.0580815
Toxoplasma gondii PAN domain-containing protein 0.0108179 0.0580067 0.0580067
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0108425 0.058212 0.11166
Echinococcus granulosus tm gpcr rhodopsin 0.0215082 0.147204 0.282361
Onchocerca volvulus 0.0108179 0.0580067 0.129131
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.00749476 0.0302797 0.0667991
Echinococcus multilocularis allatostatin A receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0108179 0.0580067 0.129131
Brugia malayi Dopamine receptor 0.0215082 0.147204 0.327696
Onchocerca volvulus 0.0108179 0.0580067 0.129131
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0108425 0.058212 0.11166
Schistosoma mansoni integrin alpha-ps 0.00688473 0.0251898 0.0555704
Echinococcus multilocularis tissue type plasminogen activator 0.00457117 0.00588611 0.0112906
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.00749476 0.0302797 0.0667991
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.00749476 0.0302797 0.0674068
Schistosoma mansoni alpha-1 adrenergic receptor 0.0215082 0.147204 0.324741
Echinococcus granulosus glycine receptor subunit alpha 1 0.00749476 0.0302797 0.0580815
Onchocerca volvulus 0.00651147 0.0220754 0.0491429
Brugia malayi PAN domain containing protein 0.0108179 0.0580067 0.129131
Toxoplasma gondii PAN/Apple domain-containing protein 0.0108179 0.0580067 0.0580067
Toxoplasma gondii PAN domain-containing protein 0.0108179 0.0580067 0.0580067
Echinococcus granulosus g protein coupled receptor 0.0215082 0.147204 0.282361
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Brugia malayi Protein kinase domain containing protein 0.00464323 0.00648732 0.0144417
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.00749476 0.0302797 0.0674068
Brugia malayi jmjC domain containing protein 0.0108425 0.058212 0.129588
Echinococcus granulosus integrin alpha 3 0.0132005 0.0778865 0.149399
Brugia malayi Cation transporter family protein 0.00749476 0.0302797 0.0674068
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0215082 0.147204 0.282361
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0215082 0.147204 0.324741
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.00991808 0.0504992 0.112418
Echinococcus multilocularis g-protein coupled receptor 0.0215082 0.147204 0.282361
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0581935 0.453295 1
Loa Loa (eye worm) hypothetical protein 0.0108179 0.0580067 0.129131
Schistosoma mansoni biogenic amine (5HT) receptor 0.0215082 0.147204 0.324741
Schistosoma mansoni cercarial elastase (S01 family) 0.00991808 0.0504992 0.111405
Loa Loa (eye worm) hypothetical protein 0.0108179 0.0580067 0.129131
Brugia malayi Dopamine receptor protein 1 0.0215082 0.147204 0.327696
Schistosoma mansoni neurotransmitter gated ion channel 0.00451858 0.00544732 0.0120172
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.00749476 0.0302797 0.0674068
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0215082 0.147204 0.324741
Brugia malayi Cation transporter family protein 0.00749476 0.0302797 0.0674068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0110607 0.0600331 0.115154
Brugia malayi Serotonin receptor 0.0215082 0.147204 0.327696
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0148207 0.0914055 0.175331
Onchocerca volvulus 0.00749476 0.0302797 0.0674068
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0148207 0.0914055 0.175331
Brugia malayi hypothetical protein 0.00879384 0.0411188 0.0915362
Toxoplasma gondii subtilisin SUB12 0.0108179 0.0580067 0.0580067
Schistosoma mansoni cercarial elastase (S01 family) 0.00991808 0.0504992 0.111405
Echinococcus multilocularis rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Echinococcus granulosus calcium activated potassium channel 0.004035 0.00141245 0.00270932
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0215082 0.147204 0.282361
Echinococcus granulosus allatostatin A receptor 0.0215082 0.147204 0.282361
Schistosoma mansoni amine GPCR 0.0215082 0.147204 0.324741
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.00451858 0.00544732 0.0121265
Entamoeba histolytica protein kinase , putative 0.0114662 0.0634166 1
Schistosoma mansoni biogenic amine receptor 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Trypanosoma brucei aurora B kinase 0.0114662 0.0634166 1
Loa Loa (eye worm) neuropeptide F receptor 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00749476 0.0302797 0.0674068
Brugia malayi PAN domain containing protein 0.0108179 0.0580067 0.129131
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.00749476 0.0302797 0.0674068
Schistosoma mansoni myosin xvIII 0.0215082 0.147204 0.324741
Echinococcus multilocularis G protein coupled receptor 139 0.0215082 0.147204 0.282361
Echinococcus granulosus G protein coupled receptor 139 0.0215082 0.147204 0.282361
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.00749476 0.0302797 0.0674068
Echinococcus multilocularis Mastin 0.00991808 0.0504992 0.0968659
Onchocerca volvulus 0.0215082 0.147204 0.327696
Echinococcus multilocularis neuropeptide s receptor 0.0663476 0.521331 1
Loa Loa (eye worm) hypothetical protein 0.00991808 0.0504992 0.112418
Trichomonas vaginalis AGC family protein kinase 0.00653998 0.0223133 0.351853
Echinococcus multilocularis fmrfamide receptor 0.0215082 0.147204 0.282361
Onchocerca volvulus 0.0215082 0.147204 0.327696
Onchocerca volvulus 0.0148207 0.0914055 0.203481
Echinococcus granulosus g-protein coupled receptor 0.0215082 0.147204 0.282361
Echinococcus granulosus integrin alpha ps 0.00688473 0.0251898 0.0483182
Brugia malayi hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0108142 0.0579763 0.129063
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0215082 0.147204 0.282361
Giardia lamblia Aurora kinase 0.0114662 0.0634166 0.5
Echinococcus granulosus glycine receptor subunit alpha 1 0.00749476 0.0302797 0.0580815
Schistosoma mansoni jumonji domain containing protein 0.00863434 0.039788 0.087775
Schistosoma mansoni serine/threonine protein kinase 0.00653998 0.0223133 0.0492247
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Brugia malayi hypothetical protein 0.0215082 0.147204 0.327696
Schistosoma mansoni neuropeptide F-like receptor 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.0118446 0.0665732 0.148201
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0597548 0.466322 1
Schistosoma mansoni jun-related protein 0.00904035 0.0431756 0.0952484
Echinococcus multilocularis neuropeptide Y receptor 0.0215082 0.147204 0.282361
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.00749476 0.0302797 0.0580815
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0215082 0.147204 0.324741
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00991808 0.0504992 0.111405
Brugia malayi Trypsin family protein 0.00991808 0.0504992 0.112418
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.00749476 0.0302797 0.0674068
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0215082 0.147204 0.327696
Brugia malayi putative neuropeptide receptor 0.0215082 0.147204 0.327696
Toxoplasma gondii PAN domain-containing protein 0.123717 1 1
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0116164 0.0646696 0.143964
Schistosoma mansoni hypothetical protein 0.00991808 0.0504992 0.111405
Toxoplasma gondii hypothetical protein 0.0108179 0.0580067 0.0580067
Loa Loa (eye worm) hypothetical protein 0.0116164 0.0646696 0.143964
Echinococcus multilocularis rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Onchocerca volvulus 0.0108179 0.0580067 0.129131
Schistosoma mansoni cercarial elastase (S01 family) 0.00991808 0.0504992 0.111405
Echinococcus granulosus ephrin type A receptor 4 A 0.00658352 0.0226766 0.0434975
Brugia malayi Trypsin family protein 0.0577037 0.449208 1
Loa Loa (eye worm) ACC-1 protein 0.00749476 0.0302797 0.0674068
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus multilocularis ephrin type A receptor 4 A 0.00658352 0.0226766 0.0434975
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0148207 0.0914055 0.203481
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.00991808 0.0504992 0.0968659
Schistosoma mansoni hypothetical protein 0.0215082 0.147204 0.324741
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus multilocularis neuropeptides capa receptor 0.0215082 0.147204 0.282361
Echinococcus multilocularis dro:myosuppressin receptor 0.0215082 0.147204 0.282361
Echinococcus multilocularis serotonin receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.00611568 0.0187731 0.0417914
Loa Loa (eye worm) hypothetical protein 0.00451858 0.00544732 0.0121265
Loa Loa (eye worm) GABA receptor subunit 0.00451858 0.00544732 0.0121265
Echinococcus granulosus aurora kinase A 0.0114662 0.0634166 0.121644
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00991808 0.0504992 0.111405
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.00749476 0.0302797 0.0580815
Brugia malayi hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0110999 0.0603596 0.134369
Brugia malayi hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.00749476 0.0302797 0.0674068
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0114662 0.0634166 1
Loa Loa (eye worm) hypothetical protein 0.00451858 0.00544732 0.0121265
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0597548 0.466322 0.894484
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0148207 0.0914055 0.201647
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus multilocularis orexin receptor type 2 0.0215082 0.147204 0.282361
Brugia malayi PAN domain containing protein 0.0108179 0.0580067 0.129131
Echinococcus multilocularis rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0215082 0.147204 0.282361
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0215082 0.147204 0.327696
Toxoplasma gondii PAN domain-containing protein 0.0108179 0.0580067 0.0580067
Echinococcus multilocularis glycoprotein Antigen 5 0.00991808 0.0504992 0.0968659
Echinococcus multilocularis jun protein 0.0110607 0.0600331 0.115154
Onchocerca volvulus 0.00451858 0.00544732 0.0121265
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.00991808 0.0504992 0.0968659
Echinococcus granulosus somatostatin receptor 0.0215082 0.147204 0.282361
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.00991808 0.0504992 0.0968659
Brugia malayi hypothetical protein 0.0215082 0.147204 0.327696
Brugia malayi Protein kinase domain containing protein 0.0346355 0.256734 0.571526
Toxoplasma gondii microneme protein MIC4 0.0108179 0.0580067 0.0580067
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Echinococcus granulosus neuropeptides capa receptor 0.0215082 0.147204 0.282361
Echinococcus granulosus tissue type plasminogen activator 0.00457117 0.00588611 0.0112906
Onchocerca volvulus 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0577037 0.449208 1
Brugia malayi serine/threonine kinase 12 0.0114662 0.0634166 0.141174
Trichomonas vaginalis AGC family protein kinase 0.0114662 0.0634166 1
Schistosoma mansoni hypothetical protein 0.00991808 0.0504992 0.111405
Brugia malayi PAN domain containing protein 0.0108179 0.0580067 0.129131
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.00749476 0.0302797 0.0674068
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0344663 0.255322 0.568382
Brugia malayi Dopamine receptor protein 2 0.0215082 0.147204 0.327696
Trypanosoma cruzi hypothetical protein, conserved 0.00457117 0.00588611 0.0928166
Echinococcus granulosus 7tm_1 domain containing protein 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Onchocerca volvulus 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) TYRA-2 protein 0.0215082 0.147204 0.327696
Brugia malayi Integrin alpha pat-2 precursor 0.0167851 0.107795 0.239968
Onchocerca volvulus 0.0148207 0.0914055 0.203481
Toxoplasma gondii PAN domain-containing protein 0.123717 1 1
Echinococcus multilocularis nAChR subunit 0.00451858 0.00544732 0.0104489
Brugia malayi Trypsin-like protease protein 5 0.00991808 0.0504992 0.112418
Brugia malayi hypothetical protein 0.0215082 0.147204 0.327696
Schistosoma mansoni protein kinase 0.0127773 0.0743555 0.164033
Loa Loa (eye worm) hypothetical protein 0.00991808 0.0504992 0.112418
Plasmodium falciparum serine/threonine protein kinase, putative 0.0114662 0.0634166 1
Leishmania major protein kinase, putative 0.0114662 0.0634166 0.135993
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Schistosoma mansoni cercarial elastase (S01 family) 0.00991808 0.0504992 0.111405
Brugia malayi hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0127773 0.0743555 0.142626
Schistosoma mansoni nAChR subunit 0.00749476 0.0302797 0.0667991
Trypanosoma cruzi aurora B kinase, putative 0.0114662 0.0634166 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0215082 0.147204 0.282361
Echinococcus multilocularis glycine receptor subunit beta 0.00749476 0.0302797 0.0580815
Schistosoma mansoni biogenic amine receptor 0.0215082 0.147204 0.324741
Echinococcus granulosus enteropeptidase 0.00991808 0.0504992 0.0968659
Loa Loa (eye worm) PAN domain-containing protein 0.0108179 0.0580067 0.129131
Entamoeba histolytica protein kinase, putative 0.00653998 0.0223133 0.290947
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0114662 0.0634166 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.00749476 0.0302797 0.0667991
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0148207 0.0914055 0.175331
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.00451858 0.00544732 0.0121265
Schistosoma mansoni neuropeptide f receptor 76f 0.0215082 0.147204 0.324741
Echinococcus granulosus rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.00990036 0.0503513 0.112089
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus granulosus 7TM GPCR rhodopsin 0.0215082 0.147204 0.282361
Echinococcus granulosus tm gpcr rhodopsin 0.0215082 0.147204 0.282361
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0148207 0.0914055 0.201647
Echinococcus granulosus nAChR subunit 0.00451858 0.00544732 0.0104489
Echinococcus multilocularis fmrfamide receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) trypsin family protein 0.00991808 0.0504992 0.112418
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0215082 0.147204 0.282361
Onchocerca volvulus 0.0215082 0.147204 0.327696
Echinococcus granulosus neuropeptide receptor A26 0.0663476 0.521331 1
Loa Loa (eye worm) hypothetical protein 0.00651147 0.0220754 0.0491429
Schistosoma mansoni cercarial elastase (S01 family) 0.00991808 0.0504992 0.111405
Schistosoma mansoni cercarial elastase (S01 family) 0.00991808 0.0504992 0.111405
Loa Loa (eye worm) AUR protein kinase 0.0114662 0.0634166 0.141174
Onchocerca volvulus 0.00991808 0.0504992 0.112418
Echinococcus granulosus biogenic amine 5HT receptor 0.0215082 0.147204 0.282361
Toxoplasma gondii microneme protein, putative 0.0108179 0.0580067 0.0580067
Echinococcus multilocularis integrin alpha ps 0.00688473 0.0251898 0.0483182
Brugia malayi PAN domain containing protein 0.0108179 0.0580067 0.129131
Entamoeba histolytica protein kinase, putative 0.0114662 0.0634166 1
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.00451858 0.00544732 0.0121265
Loa Loa (eye worm) hypothetical protein 0.00991808 0.0504992 0.112418
Echinococcus granulosus neuropeptide receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.013485 0.0802602 0.17867
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0108179 0.0580067 0.0580067
Echinococcus multilocularis integrin alpha ps 0.00688473 0.0251898 0.0483182
Schistosoma mansoni hypothetical protein 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.0148207 0.0914055 0.203481
Echinococcus granulosus serotonin receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.00749476 0.0302797 0.0674068
Loa Loa (eye worm) TK/EPH protein kinase 0.0083687 0.0375716 0.0836396
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00991808 0.0504992 0.111405
Echinococcus multilocularis enteropeptidase 0.00991808 0.0504992 0.0968659
Schistosoma mansoni cercarial elastase (S01 family) 0.00991808 0.0504992 0.111405
Onchocerca volvulus 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0108179 0.0580067 0.129131
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0215082 0.147204 0.324741
Loa Loa (eye worm) PAN domain-containing protein 0.0108179 0.0580067 0.129131
Loa Loa (eye worm) hypothetical protein 0.00451858 0.00544732 0.0121265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0215082 0.147204 0.324741
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.00457117 0.00588611 0.0131033
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus multilocularis aurora kinase A 0.0114662 0.0634166 0.121644
Onchocerca volvulus 0.00451858 0.00544732 0.0121265
Echinococcus multilocularis glycine receptor subunit alpha 1 0.00749476 0.0302797 0.0580815
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0215082 0.147204 0.327696
Brugia malayi AKH receptor 0.0215082 0.147204 0.327696
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00749476 0.0302797 0.0674068
Brugia malayi PAN domain containing protein 0.0108179 0.0580067 0.129131
Echinococcus granulosus tachykinin peptides receptor 99D 0.0215082 0.147204 0.282361
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.00749476 0.0302797 0.0580815
Brugia malayi ORL1-like opioid receptor 0.0215082 0.147204 0.327696
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.00991808 0.0504992 0.111405
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0215082 0.147204 0.324741
Schistosoma mansoni amine GPCR 0.0215082 0.147204 0.324741
Echinococcus multilocularis rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Echinococcus multilocularis rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00749476 0.0302797 0.0674068
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) G-protein coupled receptor 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0215082 0.147204 0.324741
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.00749476 0.0302797 0.0580815
Echinococcus multilocularis sex peptide receptor 0.0215082 0.147204 0.282361
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0127773 0.0743555 0.142626
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Onchocerca volvulus 0.0108179 0.0580067 0.129131
Echinococcus granulosus fmrfamide receptor 0.0215082 0.147204 0.282361
Schistosoma mansoni adenoreceptor 0.0215082 0.147204 0.324741
Echinococcus multilocularis rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Echinococcus multilocularis serotonin receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) jmjC domain-containing protein 0.00740794 0.0295553 0.0657942
Echinococcus granulosus orexin receptor type 2 0.0215082 0.147204 0.282361
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0114662 0.0634166 0.121644
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0148207 0.0914055 0.203481
Echinococcus granulosus neuropeptides capa receptor 0.0215082 0.147204 0.282361
Trichomonas vaginalis AGC family protein kinase 0.00653998 0.0223133 0.351853
Echinococcus multilocularis sodium channel protein 0.0597548 0.466322 0.894484
Onchocerca volvulus 0.00879384 0.0411188 0.0915362
Loa Loa (eye worm) hypothetical protein 0.00451858 0.00544732 0.0121265
Onchocerca volvulus 0.00991808 0.0504992 0.112418
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0215082 0.147204 0.327696
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0215082 0.147204 0.327696
Echinococcus granulosus rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Brugia malayi G protein-coupled receptor F59B2.13 0.0215082 0.147204 0.327696
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.00653998 0.0223133 0.0496725
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0215082 0.147204 0.282361
Brugia malayi follicle stimulating hormone receptor 0.0215082 0.147204 0.327696
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0215082 0.147204 0.324741
Echinococcus granulosus hypothetical protein 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.00749476 0.0302797 0.0580815
Onchocerca volvulus 0.0108179 0.0580067 0.129131
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Onchocerca volvulus 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.00749476 0.0302797 0.0667991
Brugia malayi neuropeptide F receptor 0.0215082 0.147204 0.327696
Schistosoma mansoni amine GPCR 0.0215082 0.147204 0.324741
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0114662 0.0634166 0.121644
Echinococcus granulosus nAChR subunit 0.00749476 0.0302797 0.0580815
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0215082 0.147204 0.324741
Brugia malayi RE15519p 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Echinococcus granulosus rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Onchocerca volvulus 0.00991808 0.0504992 0.112418
Brugia malayi G protein-coupled receptor 0.0215082 0.147204 0.327696
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.00991808 0.0504992 0.112418
Trichomonas vaginalis AGC family protein kinase 0.0114662 0.0634166 1
Echinococcus multilocularis calcium activated potassium channel 0.004035 0.00141245 0.00270932
Echinococcus multilocularis transmembrane protease serine 3 0.00991808 0.0504992 0.0968659
Onchocerca volvulus 0.0108179 0.0580067 0.129131
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0215082 0.147204 0.282361
Schistosoma mansoni hypothetical protein 0.00904035 0.0431756 0.0952484
Echinococcus multilocularis g protein coupled receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) PAN domain-containing protein 0.0108179 0.0580067 0.129131
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0215082 0.147204 0.327696
Loa Loa (eye worm) AUR protein kinase 0.0114662 0.0634166 0.141174
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.00653998 0.0223133 0.0428007
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.00451858 0.00544732 0.0121265
Loa Loa (eye worm) neuropeptide F receptor 0.0215082 0.147204 0.327696
Schistosoma mansoni ephrin receptor 0.00658352 0.0226766 0.0500261
Schistosoma mansoni nAChR subunit 0.00749476 0.0302797 0.0667991
Brugia malayi Protein kinase domain containing protein 0.00653998 0.0223133 0.0496725
Brugia malayi Kringle domain containing protein 0.00457117 0.00588611 0.0131033
Loa Loa (eye worm) hypothetical protein 0.00991808 0.0504992 0.112418
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.00451858 0.00544732 0.0121265
Brugia malayi larval opioid receptor 0.0215082 0.147204 0.327696
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0215082 0.147204 0.282361
Brugia malayi hypothetical protein 0.0215082 0.147204 0.327696
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0215082 0.147204 0.324741
Onchocerca volvulus Neuropeptide F receptor homolog 0.0215082 0.147204 0.327696
Entamoeba histolytica protein kinase, putative 0.0114662 0.0634166 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0110607 0.0600331 0.115154
Echinococcus granulosus neuropeptide receptor 0.0215082 0.147204 0.282361
Trichomonas vaginalis AGC family protein kinase 0.0114662 0.0634166 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.00749476 0.0302797 0.0580815
Schistosoma mansoni cercarial elastase (S01 family) 0.00991808 0.0504992 0.111405
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0114662 0.0634166 1
Echinococcus multilocularis neuropeptide Y receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0148207 0.0914055 0.203481
Schistosoma mansoni cercarial elastase (S01 family) 0.00991808 0.0504992 0.111405
Brugia malayi neuropeptide F receptor 0.0215082 0.147204 0.327696
Loa Loa (eye worm) melatonin receptor type 1A 0.0215082 0.147204 0.327696
Echinococcus multilocularis neuropeptide receptor 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Onchocerca volvulus 0.0215082 0.147204 0.327696
Loa Loa (eye worm) hypothetical protein 0.0108179 0.0580067 0.129131
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) TK/ROR protein kinase 0.00464323 0.00648732 0.0144417
Schistosoma mansoni histamine h1 receptor 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus granulosus dro:myosuppressin receptor 0.0215082 0.147204 0.282361
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0215082 0.147204 0.324741
Schistosoma mansoni biogenic amine receptor 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Onchocerca volvulus 0.00749476 0.0302797 0.0674068
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Onchocerca volvulus 0.0148207 0.0914055 0.203481
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0215082 0.147204 0.282361
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Echinococcus granulosus g protein coupled receptor 0.0215082 0.147204 0.282361
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.00451858 0.00544732 0.0121265
Schistosoma mansoni integrin alpha 0.0167851 0.107795 0.237804
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0215082 0.147204 0.324741
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Schistosoma mansoni nAChR subunit 0.00749476 0.0302797 0.0667991
Toxoplasma gondii microneme protein MIC17A 0.0108179 0.0580067 0.0580067
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00991808 0.0504992 0.111405
Echinococcus granulosus neuropeptide s receptor 0.0663476 0.521331 1
Loa Loa (eye worm) hypothetical protein 0.0108179 0.0580067 0.129131
Schistosoma mansoni neuropeptide receptor 0.0215082 0.147204 0.324741
Schistosoma mansoni cercarial elastase (S01 family) 0.00991808 0.0504992 0.111405
Echinococcus granulosus glycine receptor subunit beta 0.00749476 0.0302797 0.0580815
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.00991808 0.0504992 0.0968659
Onchocerca volvulus 0.0215082 0.147204 0.327696
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0215082 0.147204 0.327696
Loa Loa (eye worm) LGC-31 protein 0.00749476 0.0302797 0.0674068
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Loa Loa (eye worm) PAN domain-containing protein 0.0108179 0.0580067 0.129131
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0215082 0.147204 0.327696
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.00451858 0.00544732 0.0120172
Loa Loa (eye worm) ACC-1 protein 0.00749476 0.0302797 0.0674068
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.00451858 0.00544732 0.0120172
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Schistosoma mansoni amine GPCR 0.0215082 0.147204 0.324741
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.00749476 0.0302797 0.0674068
Loa Loa (eye worm) hypothetical protein 0.0215082 0.147204 0.327696
Onchocerca volvulus 0.0215082 0.147204 0.327696
Echinococcus multilocularis G-protein coupled receptor, putative 0.0215082 0.147204 0.282361
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0215082 0.147204 0.327696
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.00749476 0.0302797 0.0674068
Echinococcus granulosus neuropeptide FF receptor 2 0.0215082 0.147204 0.282361
Echinococcus granulosus biogenic amine 5HT receptor 0.0215082 0.147204 0.282361
Brugia malayi Tachykinin-like peptides receptor 99D 0.0215082 0.147204 0.327696
Onchocerca volvulus 0.0215082 0.147204 0.327696
Schistosoma mansoni amine GPCR 0.0215082 0.147204 0.324741
Echinococcus granulosus jumonji domain containing protein 0.00519981 0.0111313 0.0213516
Schistosoma mansoni neuropeptide receptor 0.0215082 0.147204 0.324741
Echinococcus multilocularis g protein coupled receptor 0.0215082 0.147204 0.282361
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0148207 0.0914055 0.175331
Schistosoma mansoni hypothetical protein 0.00457117 0.00588611 0.0129852
Loa Loa (eye worm) integrin alpha pat-2 0.0251014 0.177184 0.394437
Loa Loa (eye worm) hypothetical protein 0.00749476 0.0302797 0.0674068
Toxoplasma gondii PAN domain-containing protein 0.0108179 0.0580067 0.0580067
Onchocerca volvulus 0.0215082 0.147204 0.327696

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antimalarial activity against Plasmodium yoelii 265 BY liver stage sporozoites in primary mice (Mus musculus) hepatocytes at 7.1 uM after 48 hrs ChEMBL. 18456502
IC50 (functional) = 3.1 uM Antimalarial activity against Plasmodium yoelii 265 sporozoites in primary mice (Mus musculus) hepatocytes after 48 hrs ChEMBL. 18456502
IC50 (functional) = 4.2 uM Antimalarial activity against liver stages of Plasmodium falciparum NF54 infected in human hepatocytes assessed as growth inhibition of hepatic parasite after 5 days by fluorescence microscopy ChEMBL. 22122518

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium yoelii 18456502
Plasmodium falciparum ChEMBL23 22122518

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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