Detailed information for compound 996812

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 547.6 | Formula: C33H29N3O5
  • H donors: 3 H acceptors: 3 LogP: 6.13 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCCc1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(=O)NNC(=O)C(=O)c1c[nH]c2c1cccc2
  • InChi: 1S/C33H29N3O5/c1-40-18-17-22-9-15-27(16-10-22)41-21-23-5-4-6-26(19-23)24-11-13-25(14-12-24)32(38)35-36-33(39)31(37)29-20-34-30-8-3-2-7-28(29)30/h2-16,19-20,34H,17-18,21H2,1H3,(H,35,38)(H,36,39)
  • InChiKey: WXVJFRUQXJHDPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens insulin-like growth factor 1 receptor Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens MET proto-oncogene, receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129857 All targets in OG5_129857
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR008957,Fibronectin, type III-like fold,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/INSR protein kinase Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum ko:K04527 insulin receptor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni adapter molecule crk 0.0024 0.0111 0.0218
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0122 0.1365 0.3608
Brugia malayi Protein kinase domain containing protein 0.0092 0.0982 0.257
Giardia lamblia Kinase, CMGC CDK 0.0307 0.3723 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0076 0.0784 0.2032
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0034 0.0001
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0307 0.3723 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0001
Trypanosoma cruzi cdc2-related kinase 3 0.0307 0.3723 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0307 0.3723 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.011 0.0088
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0029 0.0183 0.0403
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0307 0.3723 1
Schistosoma mansoni tyrosine kinase 0.0018 0.0034 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0034 0.0001
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0122 0.1365 0.3608
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.011 0.5
Brugia malayi Sex muscle abnormal protein 5 0.0024 0.0111 0.0208
Onchocerca volvulus 0.0018 0.0034 0.3115
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0111 0.0208
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0018 0.0034 0.0082
Echinococcus granulosus cyclin dependent kinase 5 0.0307 0.3723 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0122 0.1365 0.3608
Plasmodium falciparum protein kinase 5 0.0307 0.3723 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0307 0.3723 1
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0034 0.0001
Echinococcus multilocularis cyclin dependent kinase 1 0.0307 0.3723 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0029 0.0183 0.0403
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0307 0.3723 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0024 0.0111 0.0218
Onchocerca volvulus 0.0024 0.011 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0122 0.1365 0.3608
Brugia malayi Tyrosine-protein kinase abl-1 0.0029 0.0183 0.0403
Brugia malayi Furin-like cysteine rich region family protein 0.0076 0.0784 0.2032
Echinococcus granulosus tyrosine protein kinase Fyn 0.0122 0.1365 0.3608
Echinococcus granulosus cyclin dependent kinase 0.0307 0.3723 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0163 0.1884 0.5015
Echinococcus granulosus tyrosine protein kinase Lyn 0.0125 0.1407 0.3721
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0307 0.3723 1
Schistosoma mansoni tyrosine kinase 0.0076 0.0784 0.204
Loa Loa (eye worm) hypothetical protein 0.0303 0.3681 0.9887
Echinococcus multilocularis cyclin dependent kinase 1 0.0307 0.3723 1
Schistosoma mansoni tyrosine kinase 0.0076 0.0784 0.204
Trichomonas vaginalis CMGC family protein kinase 0.0307 0.3723 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0034 0.0001
Schistosoma mansoni tyrosine kinase 0.0122 0.1365 0.3615
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0034 0.0001
Loa Loa (eye worm) TK/EGFR protein kinase 0.0076 0.0784 0.2033
Schistosoma mansoni growth factor receptor-bound protein 0.0024 0.0111 0.0218
Trichomonas vaginalis CMGC family protein kinase 0.0307 0.3723 0.5
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0111 0.0208
Echinococcus multilocularis tyrosine protein kinase HCK 0.0098 0.1064 0.2791
Schistosoma mansoni tyrosine kinase 0.0029 0.0183 0.0413
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0163 0.1884 0.5015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.011 0.0284
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0034 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0024 0.011 0.0205
Echinococcus multilocularis tyrosine protein kinase Srms 0.011 0.1216 0.3205
Loa Loa (eye worm) TK protein kinase 0.0098 0.1064 0.2792
Echinococcus multilocularis cyclin dependent kinase 5 0.0307 0.3723 1
Echinococcus multilocularis NCK adaptor protein 0.0024 0.0111 0.0208
Echinococcus multilocularis plexin a4 0.0025 0.0124 0.0245
Brugia malayi AMP-binding enzyme family protein 0.0024 0.011 0.0205
Onchocerca volvulus 0.0018 0.0034 0.3115
Echinococcus granulosus cyclin dependent kinase 1 0.0307 0.3723 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.0209
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.011 0.0284
Schistosoma mansoni tyrosine kinase 0.0122 0.1365 0.3615
Loa Loa (eye worm) SRC-1 0.0122 0.1365 0.3609
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0122 0.1365 0.3608
Echinococcus granulosus tyrosine protein kinase Blk 0.011 0.1216 0.3205
Brugia malayi AMP-binding enzyme family protein 0.0024 0.011 0.0205
Entamoeba histolytica cell division protein kinase 2, putative 0.0307 0.3723 1
Onchocerca volvulus 0.0018 0.0034 0.3115
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0034 0.0001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0122 0.1365 0.3608
Echinococcus granulosus tyrosine protein kinase Fyn 0.0122 0.1365 0.3608
Echinococcus multilocularis tyrosine protein kinase Blk 0.011 0.1216 0.3205
Trypanosoma brucei cdc2-related kinase 1 0.0307 0.3723 0.5
Brugia malayi protein-tyrosine kinase 0.011 0.1216 0.3205
Schistosoma mansoni nck2/grb4 0.0024 0.0111 0.0218
Giardia lamblia Kinase, CMGC CDK 0.0307 0.3723 0.5
Schistosoma mansoni tyrosine kinase 0.0163 0.1884 0.502
Trypanosoma brucei cdc2-related kinase 3 0.0307 0.3723 0.5
Echinococcus granulosus tyrosine kinase 0.011 0.1216 0.3205
Echinococcus multilocularis insulin receptor 0.0163 0.1884 0.5015
Mycobacterium ulcerans haloalkane dehalogenase 0.0798 1 1
Onchocerca volvulus 0.0018 0.0034 0.3115
Brugia malayi SRC-1 0.0122 0.1365 0.3608
Loa Loa (eye worm) hypothetical protein 0.0024 0.011 0.0206
Schistosoma mansoni tyrosine kinase 0.0163 0.1884 0.502
Echinococcus granulosus tyrosine protein kinase Src42A 0.0105 0.1144 0.3009
Onchocerca volvulus 0.0018 0.0034 0.3115
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0034 0.0001
Schistosoma mansoni tyrosine kinase 0.0071 0.0711 0.1844
Loa Loa (eye worm) hypothetical protein 0.0086 0.091 0.2375
Loa Loa (eye worm) plexin A 0.0025 0.0124 0.0246
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0114
Echinococcus granulosus tyrosine protein kinase Src64B 0.0122 0.1365 0.3608
Brugia malayi Protein kinase domain containing protein 0.0307 0.3723 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0029 0.0183 0.0403
Echinococcus multilocularis c src tyrosine kinase 0.0029 0.0183 0.0403
Brugia malayi cell division control protein 2 homolog 0.0307 0.3723 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0122 0.1365 0.3608
Echinococcus multilocularis tyrosine protein kinase Fyn 0.011 0.1216 0.3205
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0122 0.1365 0.3608
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.011 0.0076
Schistosoma mansoni growth factor receptor-bound protein 0.0024 0.0111 0.0218
Echinococcus multilocularis epidermal growth factor receptor 0.0076 0.0784 0.2032
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0034 0.0012
Entamoeba histolytica cell division protein kinase 2, putative 0.0307 0.3723 1
Loa Loa (eye worm) TK protein kinase 0.011 0.1216 0.3205
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0122 0.1365 0.3608
Echinococcus multilocularis 0.0021 0.0073 0.0106
Trypanosoma cruzi cdc2-related kinase 1 0.0307 0.3723 0.5
Schistosoma mansoni tyrosine kinase 0.0018 0.0034 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.011 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0307 0.3723 1
Echinococcus granulosus NCK adaptor protein 0.0024 0.0111 0.0208
Mycobacterium ulcerans hypothetical protein 0.0024 0.011 0.0076
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0122 0.1365 0.3608
Echinococcus granulosus insulin receptor 0.0163 0.1884 0.5015
Loa Loa (eye worm) TK/ABL protein kinase 0.0018 0.0034 0.0001
Schistosoma mansoni tyrosine kinase 0.0071 0.0711 0.1844
Echinococcus granulosus plexin a4 0.0025 0.0124 0.0245
Loa Loa (eye worm) hypothetical protein 0.0024 0.011 0.0206
Echinococcus granulosus tyrosine protein kinase HCK 0.0098 0.1064 0.2791
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.011 0.0284
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0024 0.0111 0.0209
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.011 0.1216 0.3205
Brugia malayi Plexin repeat family protein 0.0021 0.0076 0.0113
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.011 0.0076
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0122 0.1365 0.3608
Onchocerca volvulus 0.0021 0.0076 0.6904
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0105 0.1144 0.3009
Echinococcus granulosus c src tyrosine kinase 0.0029 0.0183 0.0403
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.011 0.0088
Trypanosoma cruzi cdc2-related kinase 1 0.0307 0.3723 0.5
Plasmodium vivax protein kinase Crk2 0.0307 0.3723 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0029 0.0183 0.0413
Trichomonas vaginalis CMGC family protein kinase 0.0307 0.3723 0.5
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.011 0.0076
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0122 0.1365 0.3608
Schistosoma mansoni tyrosine kinase 0.0071 0.0711 0.1844
Echinococcus multilocularis cyclin dependent kinase 0.0307 0.3723 1
Echinococcus granulosus epidermal growth factor receptor 0.0076 0.0784 0.2032
Echinococcus multilocularis epidermal growth factor receptor 0.0076 0.0784 0.2032
Schistosoma mansoni tyrosine kinase 0.0076 0.0784 0.204
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.011 0.0076
Brugia malayi Protein kinase domain containing protein 0.0163 0.1884 0.5015
Schistosoma mansoni tyrosine kinase 0.0029 0.0183 0.0413
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0034 0.0001
Echinococcus granulosus growth factor receptor bound protein 2 0.0024 0.0111 0.0208
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0307 0.3723 0.5
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0034 0.5
Echinococcus multilocularis growth factor receptor bound protein 2 0.0024 0.0111 0.0208
Brugia malayi plexin A 0.0025 0.0124 0.0245
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0024 0.0111 0.0209
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0307 0.3723 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.011 0.0076
Entamoeba histolytica protein kinase, putative 0.0098 0.1064 0.285
Schistosoma mansoni plexin 0.0021 0.0076 0.0123
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0034 0.0001
Trypanosoma cruzi cdc2-related kinase 3 0.0307 0.3723 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0076 0.0784 0.2032
Echinococcus granulosus tyrosine protein kinase Fyn 0.0122 0.1365 0.3608
Loa Loa (eye worm) TK/INSR protein kinase 0.0163 0.1884 0.5015
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.011 0.0076
Loa Loa (eye worm) hypothetical protein 0.0024 0.011 0.0206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.011 0.5
Onchocerca volvulus 0.0018 0.0034 0.3115

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.38 uM Inhibition of SRC assessed as incorporation of p33 using [gammaP33]-ATP by microplate scintillation counting ChEMBL. 21524503
IC50 (binding) = 0.68 uM Inhibition of IGF-1R assessed as incorporation of p33 using [gammaP33]-ATP by microplate scintillation counting ChEMBL. 21524503
IC50 (binding) = 8.8 uM Inhibition of c-MET assessed as incorporation of p33 using [gammaP33]-ATP by microplate scintillation counting ChEMBL. 21524503

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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