Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0029 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0029 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0029 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0249 | 1 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0249 | 1 | 1 | |
Echinococcus granulosus | nmda type glutamate receptor | 0.0127 | 0.4467 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0032 | 0.0131 | 0.0293 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0109 | 0.3629 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.022 | 0.8676 | 0.8676 |
Mycobacterium ulcerans | hypothetical protein | 0.0029 | 0 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.022 | 0.8676 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.3012 | 0.6743 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0249 | 1 | 1 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.3012 | 0.6743 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.01 | 0.3221 | 0.7211 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0127 | 0.4467 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0029 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.022 | 0.8676 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.022 | 0.8676 | 0.8676 |
Echinococcus granulosus | nmda type glutamate receptor | 0.01 | 0.3221 | 0.7211 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0029 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.022 | 0.8676 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0249 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.022 | 0.8676 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0249 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.14 uM | Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current by two electrode voltage clamp method | ChEMBL. | 18800760 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.