Target list

Search results for query: Weighted ranking of Mtb targets based on gene essentiality and expression during persistence for PLOS-NTD

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #9 (Mtb weighted list for gene attenuation score as in Murphy-Brown data): weighted list
  • Score for genes in query #5 (Mtu PDB structures): 20
  • Score for genes in query #2 (Hasan 2006 persistence, revised):
  • Score for genes in query #8 (Mtu all proteins): 1
  • Score for genes in query #10 (Mtb weighted list for persistence expression score as in Murphy-Brown data): weighted list

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

2253 records found | Showing page 1 of 91 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv0885   OG5_237762   Conserved hypothetical protein 597
M. tuberculosis   Rv3290c   OG5_129508   Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysi ... 583
M. tuberculosis   Rv2780   OG5_127241   Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43) 571
M. tuberculosis   Rv3340   OG5_130839   Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetyl ... 536
M. tuberculosis   Rv2629     No group Conserved protein 524
M. tuberculosis   Rv2004c   OG5_142650   Conserved protein 520
M. tuberculosis   Rv2626c   OG5_130004   Hypoxic response protein 1 Hrp1 495
M. tuberculosis   Rv0275c   OG5_179227   Possible transcriptional regulatory protein (possibly TetR-family) 478
M. tuberculosis   Rv2628     No group Hypothetical protein 476
M. tuberculosis   Rv2830c     No group Possible antitoxin VapB22 473
M. tuberculosis   Rv2035     No group Conserved hypothetical protein 469
M. tuberculosis   Rv2623   OG5_126997   Universal stress protein family protein TB31.7 456
M. tuberculosis   Rv2630     No group Hypothetical protein 454
M. tuberculosis   Rv2497c   OG5_128261   Probable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA 453
M. tuberculosis   Rv2115c   OG5_237684   Mycobacterial proteasome ATPase Mpa 451
M. tuberculosis   Rv2032   OG5_179425   Conserved protein Acg 448
M. tuberculosis   Rv2711   OG5_132027   Iron-dependent repressor and activator IdeR 440
M. tuberculosis   Rv2624c   OG5_126997   Universal stress protein family protein 440
M. tuberculosis   Rv2627c   OG5_239110   Conserved protein 440
M. tuberculosis   Rv3131   OG5_179425   Conserved protein 435
M. tuberculosis   Rv1813c   OG5_239134   Conserved hypothetical protein 426
M. tuberculosis   Rv3126c     No group Hypothetical protein 421
M. tuberculosis   Rv3130c   OG5_133846   Triacylglycerol synthase (diacylglycerol acyltransferase) Tgs1 412
M. tuberculosis   Rv2496c   OG5_128323   Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB 404
M. tuberculosis   Rv3841   OG5_127547   Bacterioferritin BfrB 399