TDR Targets

Basic information

Technical information

TDR Targets ID: 578118
Name: 4,6-dioxo-1H-1,3,5-triazine-2-carboxamide
MW: 156.1 | Formula: C4H4N4O3
H donors: 3 H acceptors: 3 LogP: -1.61 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=c1[nH]c(=O)[nH]c(n1)C(=O)N
InChi: 1S/C4H4N4O3/c5-1(9)2-6-3(10)8-4(11)7-2/h(H2,5,9)(H2,6,7,8,10,11)
InChiKey: HJXJVORILFDIOT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4,6-diketo-1H-s-triazine-2-carboxamide
allantoxanamide
69391-08-8
2,4-Dihydroxy-6-carboxamide-1,3,5-triazine
Oxonamide
1,3,5-Triazine-2-carboxamide, 1,4,5,6-tetrahydro-4,6-dioxo-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0286	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1449	0.3761
Schistosoma mansoni	hypothetical protein	0.0248	0.3047	0.7894
Trichomonas vaginalis	ran, putative	0.0021	0.0112	0.3772
Echinococcus granulosus	lamin	0.0027	0.019	0.0478
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0286	0.5
Brugia malayi	Transmembrane protein 16C	0.0248	0.3047	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0069	0.0163
Brugia malayi	intermediate filament protein	0.0027	0.019	0.0546
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0286	0.0688
Onchocerca volvulus		0.0035	0.0286	0.0763
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.0023	0.0043
Brugia malayi	RNA, U transporter 1	0.0083	0.0905	0.2913
Brugia malayi	beta-lactamase	0.0035	0.0286	0.0864
Toxoplasma gondii	ABC1 family protein	0.0035	0.0286	0.1507
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0112	0.0287
Schistosoma mansoni	importin beta-1	0.0029	0.0211	0.0492
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.019	0.0494
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0286	0.0688
Onchocerca volvulus		0.0035	0.0286	0.0763
Schistosoma mansoni	intermediate filament proteins	0.0027	0.019	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1449	0.3761
Leishmania major	hypothetical protein, unknown function	0.0022	0.0122	0.0592
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0211	0.0859
Echinococcus granulosus	geminin	0.0184	0.2222	0.576
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0286	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0286	0.0743
Brugia malayi	beta-lactamase family protein	0.0035	0.0286	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0286	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0027	0.019	0.0494
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0286	0.5
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0286	0.0743
Echinococcus multilocularis	protein of unknown function DUF590	0.0022	0.0122	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0286	0.0743
Echinococcus multilocularis	anoctamin 8	0.0022	0.0122	0.0116
Onchocerca volvulus		0.0058	0.0592	0.319
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0112	0.0291
Echinococcus multilocularis	protein of unknown function DUF590	0.015	0.1771	0.1766
Onchocerca volvulus	Huntingtin homolog	0.0125	0.1449	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.014	0.1617
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0286	0.0743
Echinococcus granulosus	snurportin 1	0.031	0.3853	1
Echinococcus multilocularis	geminin	0.0184	0.2222	0.2217
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0111	0.1269	1
Schistosoma mansoni	hypothetical protein	0.015	0.1771	0.4564
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.0023	0.0017
Schistosoma mansoni	ran	0.0021	0.0112	0.0232
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0286	1
Brugia malayi	hypothetical protein	0.0125	0.1449	0.4712
Schistosoma mansoni	lamin	0.0027	0.019	0.0437
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0112	0.0274
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0211	0.5701
Echinococcus multilocularis	cpg binding protein	0.0062	0.0635	0.0629
Schistosoma mansoni	hypothetical protein	0.0184	0.2222	0.5742
Echinococcus multilocularis	musashi	0.0027	0.019	0.0184
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0286	0.5
Echinococcus multilocularis	protein of unknown function DUF590	0.015	0.1771	0.1766
Schistosoma mansoni	lamin	0.0027	0.019	0.0437
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0124	0.144	0.37
Echinococcus granulosus	intermediate filament protein	0.0027	0.019	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0211	0.0549
Leishmania major	importin beta-1 subunit, putative	0.0024	0.014	0.1617
Echinococcus granulosus	lamin dm0	0.0027	0.019	0.0478
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0286	0.0728
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0286	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0286	0.5
Echinococcus granulosus	anoctamin 8	0.0022	0.0122	0.0301
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0066	0.0135
Trichomonas vaginalis	esterase, putative	0.0035	0.0286	1
Echinococcus granulosus	protein of unknown function DUF590	0.0022	0.0122	0.0301
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.014	0.4779
Mycobacterium ulcerans	lipase LipD	0.0035	0.0286	0.5
Leishmania major	hypothetical protein, conserved	0.0035	0.0286	1
Schistosoma mansoni	hypothetical protein	0.0022	0.0122	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0286	0.0743
Onchocerca volvulus	Huntingtin homolog	0.0125	0.1449	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.014	0.4779
Schistosoma mansoni	cpg binding protein	0.0058	0.0592	0.1485
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.014	0.4779
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0007	0.0017
Entamoeba histolytica	hypothetical protein	0.0024	0.014	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.2719	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0286	0.0864
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0286	1
Schistosoma mansoni	hypothetical protein	0.0022	0.0122	0.0259
Schistosoma mansoni	cpg binding protein	0.0062	0.0635	0.1598
Plasmodium falciparum	importin beta, putative	0.0029	0.0211	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0286	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.031	0.3853	1
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0211	0.0205
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0211	0.5701
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0112	0.0106
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0286	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0286	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.019	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0184	0.0477
Onchocerca volvulus		0.0035	0.0286	0.0763
Schistosoma mansoni	cpg binding protein	0.0062	0.0635	0.1598
Echinococcus granulosus	protein of unknown function DUF590	0.015	0.1771	0.4587
Schistosoma mansoni	hypothetical protein	0.031	0.3853	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.019	0.0494
Echinococcus multilocularis	lamin dm0	0.0027	0.019	0.0184
Brugia malayi	Importin beta-1 subunit	0.0029	0.0211	0.0616
Schistosoma mansoni	ran	0.0021	0.0112	0.0232
Giardia lamblia	Hypothetical protein	0.0022	0.0122	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.0023	0.0017
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.0023	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0286	0.0743
Echinococcus granulosus	protein of unknown function DUF590	0.015	0.1771	0.4587
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0286	1
Brugia malayi	CXXC zinc finger family protein	0.0058	0.0592	0.1875
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0211	0.5701
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0286	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0058	0.0592	0.1536
Echinococcus multilocularis	snurportin 1	0.031	0.3853	0.3849
Echinococcus granulosus	cpg binding protein	0.0062	0.0635	0.1634
Schistosoma mansoni	hypothetical protein	0.0184	0.2222	0.5742
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0286	0.5
Loa Loa (eye worm)	hypothetical protein	0.0248	0.3047	0.7907
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0211	0.0533
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0286	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0069	0.0063
Echinococcus multilocularis	lamin	0.0027	0.019	0.0184
Onchocerca volvulus		0.0121	0.1398	0.9593
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0286	0.028
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0025	0.0066
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0069	0.018
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0286	0.0864

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 188244

Bibliographic References

No literature references available for this target.

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Detailed information for compound 578118