TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 325.408 | Formula: C18H23N5O
H donors: 1 H acceptors: 3 LogP: 1.81 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)C1CCN(CC1)c1ccnc(n1)c1cccc(c1)N(C)C
InChi: 1S/C18H23N5O/c1-22(2)15-5-3-4-14(12-15)18-20-9-6-16(21-18)23-10-7-13(8-11-23)17(19)24/h3-6,9,12-13H,7-8,10-11H2,1-2H3,(H2,19,24)
InChiKey: XBQFYTFSCZLPQF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	RNA binding protein	0.0062	0.147	0.2077
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0093	0.0132
Schistosoma mansoni	thyroid hormone receptor	0.0007	0.0093	0.0093
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0007	0.0093	0.0093
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0067	0.0121
Schistosoma mansoni	cpg binding protein	0.0028	0.0615	0.0615
Schistosoma mansoni	RAR-like nuclear receptor	0.0007	0.0093	0.0093
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0007	0.0093	0.0132
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0067	0.0121
Onchocerca volvulus	Protein ultraspiracle homolog	0.0007	0.0093	0.0681
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0188	0.0686
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.147	0.147
Brugia malayi	serine/threonine kinase 12	0.0113	0.2746	0.3882
Schistosoma mansoni	ap endonuclease	0.0018	0.037	0.037
Toxoplasma gondii	exonuclease III APE	0.0018	0.037	0.1349
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0067	0.0121
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.037	0.037
Schistosoma mansoni	retinoic acid receptor RXR	0.0007	0.0093	0.0093
Echinococcus granulosus	intraflagellar transport protein 88	0.0011	0.0188	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0093	0.0132
Entamoeba histolytica	protein kinase , putative	0.0113	0.2746	1
Trichomonas vaginalis	AGC family protein kinase	0.0113	0.2746	0.4966
Trichomonas vaginalis	TKL family protein kinase	0.0012	0.0212	0.0383
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0067	0.0121
Loa Loa (eye worm)	AUR protein kinase	0.0113	0.2746	0.3882
Treponema pallidum	hypothetical protein	0.0011	0.0188	0.5087
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0113	0.2746	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.037	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0082	0.0082
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0007	0.0093	0.0093
Trichomonas vaginalis	AGC family protein kinase	0.0113	0.2746	0.4966
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0007	0.0093	0.0132
Brugia malayi	steroid hormone receptor	0.0007	0.0093	0.0132
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.037	1
Echinococcus multilocularis	intraflagellar transport protein 88	0.0011	0.0188	0.0188
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0082	0.0082
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0113	0.2746	1
Schistosoma mansoni	ap endonuclease	0.0018	0.037	0.037
Brugia malayi	ecdysteroid receptor	0.0007	0.0093	0.0132
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0004	0.0005	0.0005
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.037	0.037
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.147	0.2077
Loa Loa (eye worm)	AUR protein kinase	0.0113	0.2746	0.3882
Trypanosoma brucei	serine/threonine protein phosphatase 5	0.0011	0.0188	0.0686
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0007	0.0093	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0093	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0093	0.0132
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0007	0.0093	0.0132
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0007	0.0093	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0188	0.0341
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0007	0.0093	0.0132
Schistosoma mansoni	peptidyl-prolyl cis-trans isomerase G ppig	0.0224	0.553	0.553
Trichomonas vaginalis	helicase, putative	0.0006	0.0067	0.0121
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0082	0.0082
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0126	0.0178
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0007	0.0093	0.0132
Schistosoma mansoni	nuclear hormone receptor	0.0007	0.0093	0.0093
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.037	0.1349
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.037	0.1349
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0188	0.0266
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0082	0.0082
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0113	0.2746	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0093	0.0132
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0615	0.0869
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0067	0.0121
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.147	0.147
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0067	0.0121
Onchocerca volvulus		0.0028	0.0615	0.4495
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0188	0.0266
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0007	0.0093	0.0093
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0004	0.0005	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0005	0.0007
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.037	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0007	0.0093	0.0132
Loa Loa (eye worm)	AUR protein kinase	0.0113	0.2746	0.3882
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0007	0.0093	0.0093
Brugia malayi	hypothetical protein	0.0004	0.0005	0.0007
Schistosoma mansoni	coup transcription factor	0.0007	0.0093	0.0093
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.147	0.147
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0004	0.0005	0.0005
Trichomonas vaginalis	peptidyl-prolyl cis-trans isomerase A, ppia, putative	0.0224	0.553	1
Treponema pallidum	hypothetical protein	0.0011	0.0188	0.5087
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0067	0.0121
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0067	0.0121
Giardia lamblia	Dynein binding protein, putative	0.0011	0.0188	0.0686
Trichomonas vaginalis	AGC family protein kinase	0.0113	0.2746	0.4966
Toxoplasma gondii	aurora kinase	0.0113	0.2746	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0067	0.0121
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0007	0.0093	0.0132
Schistosoma mansoni	G-protein signalling modulator	0.0011	0.0188	0.0188
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0007	0.0093	0.0132
Giardia lamblia	Aurora kinase	0.0113	0.2746	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0007	0.0093	0.0132
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.147	0.2077
Schistosoma mansoni	cell division cycle	0.0011	0.0188	0.0188
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0615	0.0869
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0007	0.0093	0.0093
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0007	0.0093	0.0093
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.147	0.2077
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0007	0.0093	0.0093
Brugia malayi	protein C18H9.7	0.0011	0.0188	0.0266
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0007	0.0093	0.0093
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.037	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0005	0.0007
Loa Loa (eye worm)	steroid hormone receptor	0.0007	0.0093	0.0132
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0007	0.0093	0.0093
Schistosoma mansoni	cpg binding protein	0.003	0.0655	0.0655
Trypanosoma cruzi	aurora B kinase, putative	0.0113	0.2746	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0007	0.0093	0.0093
Echinococcus granulosus	ecdysone induced protein 78C	0.0007	0.0093	0.0093
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.037	0.1349
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0067	0.0121
Echinococcus granulosus	FTZ F1 alpha	0.0007	0.0093	0.0093
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.037	0.067
Schistosoma mansoni	hypothetical protein	0.0011	0.0188	0.0188
Leishmania major	cyclophilin 40	0.0112	0.2729	0.9937
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.037	0.1349
Trichomonas vaginalis	AGC family protein kinase	0.0113	0.2746	0.4966
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0007	0.0093	0.0093
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0126	0.0126
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0126	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0005	0.0007
Trypanosoma brucei	aurora B kinase	0.0113	0.2746	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0007	0.0093	0.0132
Treponema pallidum	hypothetical protein	0.0011	0.0188	0.5087
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0007	0.0093	0.0132
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0067	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0005	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0007	0.0093	0.0132
Brugia malayi	nuclear hormone receptor	0.0007	0.0093	0.0132
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0004	0.0005	0.0005
Schistosoma mansoni	cpg binding protein	0.003	0.0655	0.0655
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.037	0.1349
Brugia malayi	TAR-binding protein	0.0062	0.147	0.2077
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0067	0.0121
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.141	0.141
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.1368	0.1934
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.1249	0.4548
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0093	0.0132
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0007	0.0093	0.0093
Echinococcus multilocularis	FTZ F1 alpha	0.0007	0.0093	0.0093
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0082	0.0082
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.7074	0.7074
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0007	0.0093	0.0132
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0007	0.0093	0.0132
Onchocerca volvulus		0.0007	0.0093	0.0681
Trypanosoma cruzi	rotamase, putative	0.0112	0.2729	0.9937
Brugia malayi	Nuclear hormone receptor-like 1	0.0004	0.0005	0.0007
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0113	0.2746	1
Schistosoma mansoni	serine/threonine protein kinase	0.0113	0.2746	0.2746
Echinococcus granulosus	cpg binding protein	0.003	0.0655	0.0655
Brugia malayi	serine/threonine protein kinase 6	0.0113	0.2746	0.3882
Brugia malayi	Nuclear hormone receptor-like 1	0.0004	0.0005	0.0007
Echinococcus multilocularis	dnaJ subfamily B	0.0402	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0007	0.0093	0.0093
Brugia malayi	RNA binding protein	0.0062	0.147	0.2077
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0008	0.0008
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0113	0.2746	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0007	0.0093	0.0093
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0007	0.0093	0.0132
Trypanosoma cruzi	40 kDa cyclophilin, putative	0.0112	0.2729	0.9937
Trichomonas vaginalis	cyclophillin, putative	0.0112	0.2729	0.4935
Echinococcus multilocularis	cpg binding protein	0.003	0.0655	0.0655
Echinococcus granulosus	aurora kinase A	0.0113	0.2746	0.2746
Onchocerca volvulus		0.0058	0.1368	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0007	0.0093	0.0132
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0113	0.2746	1
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.2746	1
Echinococcus multilocularis	peptidyl prolyl isomerase G	0.0224	0.553	0.553
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0067	0.0121
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0007	0.0093	0.0093
Brugia malayi	nuclear receptor NHR-88	0.0007	0.0093	0.0132
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.037	0.067
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.147	0.147
Brugia malayi	serine/threonine-protein kinase 6	0.0113	0.2746	0.3882
Onchocerca volvulus	Bile acid receptor homolog	0.0007	0.0093	0.0681
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.037	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0007	0.0093	0.0093
Brugia malayi	hypothetical protein	0.0004	0.0005	0.0007
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0007	0.0093	0.0132
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0007	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0093	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0067	0.0121
Brugia malayi	nuclear receptor RXR	0.0004	0.0005	0.0007
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0007	0.0093	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0067	0.0121
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.037	0.1349
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0113	0.2746	0.2746
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0007	0.0093	0.0093
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0007	0.0093	0.0093
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0007	0.0093	0.0093
Echinococcus granulosus	tar DNA binding protein	0.0062	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0005	0.0007
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0007	0.0093	0.0093
Entamoeba histolytica	protein kinase, putative	0.0113	0.2746	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0004	0.0005	0.0005
Treponema pallidum	hypothetical protein	0.0011	0.0188	0.5087
Schistosoma mansoni	peptidyl-prolyl cis-trans isomerase G ppig	0.0224	0.553	0.553
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0007	0.0093	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0093	0.0132
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0007	0.0093	0.0132
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0123	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0067	0.0121
Brugia malayi	Steroid receptor seven-up type 2	0.0007	0.0093	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0067	0.0121
Schistosoma mansoni	hypothetical protein	0.0058	0.1368	0.1368
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.7074	0.7074
Schistosoma mansoni	hypothetical protein	0.0402	1	1
Echinococcus granulosus	peptidyl prolyl isomerase G	0.0224	0.553	0.553
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase (cyclophilin- 40), putative	0.0112	0.2729	0.9937
Schistosoma mansoni	protein kinase	0.0113	0.2746	0.2746
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.037	0.0524
Echinococcus multilocularis	aurora kinase A	0.0113	0.2746	0.2746
Brugia malayi	hypothetical protein	0.0286	0.7074	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.037	0.1349
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0007	0.0093	0.0132
Entamoeba histolytica	protein kinase, putative	0.0113	0.2746	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.147	0.147
Schistosoma mansoni	thyroid hormone receptor	0.0007	0.0093	0.0093
Schistosoma mansoni	survival motor neuron protein	0.0058	0.1368	0.1368
Echinococcus multilocularis	G protein signaling modulator 2	0.0011	0.0188	0.0188
Brugia malayi	Nuclear hormone receptor-like 1	0.0007	0.0093	0.0132
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.037	0.1349
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0112	0.2729	0.9937
Loa Loa (eye worm)	hypothetical protein	0.0286	0.7074	1
Leishmania major	protein kinase, putative	0.0113	0.2746	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 306 %	Activation of SMN expressed in HEK293 cells assessed as rate of induction by SMN2-promotor driven luciferase reporter gene assay relative to basal level	ChEMBL.	21819082
Activity (binding)	= 12.24 uM	Activation of SMN expressed in HEK293 cells assessed as concentration required to reach 50% of maximum luciferase signal by SMN2-promotor driven luciferase reporter gene assay	ChEMBL.	21819082
Potency (functional)	12.2411 uM	PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Enhancers of SMN2 Splice Variant Expression for Further Probe SAR. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1474]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1715864

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1483982