Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor subunit alpha-6 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glycogen synthase | 0.0212 | 0.3128 | 0.2405 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0128 | 0.1251 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0128 | 0.1251 | 0.368 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0224 | 0.34 | 0.2706 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0224 | 0.34 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0073 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0129 | 0.1256 | 0.0337 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0128 | 0.1251 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0224 | 0.34 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0073 | 0 | 0.5 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0224 | 0.34 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0073 | 0 | 0.5 |
Schistosoma mansoni | glycogen synthase | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Giardia lamblia | Glycogen synthase, putative | 0.0519 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0224 | 0.34 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0224 | 0.34 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0224 | 0.34 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0128 | 0.1251 | 0.368 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.3128 | 0.2405 |
Echinococcus multilocularis | glycogen synthase | 0.0519 | 1 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0224 | 0.34 | 0.5 |
Onchocerca volvulus | Glycogen synthase homolog | 0.0519 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0128 | 0.1251 | 0.5 |
Loa Loa (eye worm) | ILVBL protein | 0.0136 | 0.1418 | 0.0516 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0073 | 0 | 0.5 |
Echinococcus granulosus | glycogen synthase | 0.0519 | 1 | 1 |
Brugia malayi | Glycogen synthase | 0.0212 | 0.3128 | 0.2405 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0128 | 0.1251 | 0.368 |
Loa Loa (eye worm) | glycogen synthase | 0.0212 | 0.3128 | 0.2405 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 37.4 nM | Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release | ChEMBL. | 21147530 |
Imax (functional) | = 65 % | Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release relative to nicotine | ChEMBL. | 21147530 |
Inhibition (functional) | = 36 % | Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release at 100 nM relative to control | ChEMBL. | 21147530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.