Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0686 | 0.4765 | 0.4752 |
Plasmodium falciparum | plasmepsin VI | 0.0686 | 0.4765 | 1 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0176 | 0.1175 | 0.2322 |
Leishmania major | exportin 1, putative | 0.0022 | 0.0089 | 0.5 |
Trichomonas vaginalis | chromosome region maintenance protein, putative | 0.0022 | 0.0087 | 0.0183 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0686 | 0.4765 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.143 | 1 | 1 |
Plasmodium falciparum | plasmepsin V | 0.0176 | 0.1175 | 0.2322 |
Plasmodium falciparum | plasmepsin IV | 0.0686 | 0.4765 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0686 | 0.4765 | 0.4719 |
Plasmodium falciparum | plasmepsin III | 0.0176 | 0.1175 | 0.2322 |
Plasmodium vivax | aspartyl protease, putative | 0.0176 | 0.1175 | 0.2322 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0176 | 0.1175 | 0.1095 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0176 | 0.1175 | 0.1095 |
Brugia malayi | hypothetical protein | 0.0176 | 0.1175 | 0.1095 |
Loa Loa (eye worm) | glycogen synthase | 0.0584 | 0.405 | 0.4035 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0176 | 0.1175 | 0.2322 |
Plasmodium vivax | plasmepsin V, putative | 0.0176 | 0.1175 | 0.2322 |
Loa Loa (eye worm) | nuclear export factor CRM1 | 0.0014 | 0.0036 | 0.0011 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0686 | 0.4765 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0176 | 0.1175 | 0.1097 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0176 | 0.1175 | 0.1097 |
Plasmodium vivax | aspartyl protease, putative | 0.0176 | 0.1175 | 0.2322 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0176 | 0.1175 | 0.1153 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0176 | 0.1175 | 0.1097 |
Plasmodium vivax | plasmepsin IV, putative | 0.0686 | 0.4765 | 1 |
Brugia malayi | Pepsin A precursor | 0.0176 | 0.1175 | 0.1095 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0176 | 0.1175 | 0.1097 |
Trypanosoma brucei | exportin 1 | 0.0022 | 0.0089 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0686 | 0.4765 | 0.4718 |
Plasmodium falciparum | plasmepsin IX | 0.0176 | 0.1175 | 0.2322 |
Loa Loa (eye worm) | hypothetical protein | 0.143 | 1 | 1 |
Brugia malayi | Glycogen synthase | 0.0584 | 0.405 | 0.3996 |
Loa Loa (eye worm) | hypothetical protein | 0.143 | 1 | 1 |
Toxoplasma gondii | aspartyl protease | 0.0176 | 0.1175 | 0.2322 |
Schistosoma mansoni | chromosome region maintenance protein 1/exportin | 0.0022 | 0.0089 | 0.0002 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0176 | 0.1175 | 0.1153 |
Loa Loa (eye worm) | hypothetical protein | 0.143 | 1 | 1 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0176 | 0.1175 | 0.2322 |
Plasmodium falciparum | plasmepsin II | 0.0686 | 0.4765 | 1 |
Onchocerca volvulus | Glycogen synthase homolog | 0.143 | 1 | 1 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0176 | 0.1175 | 0.1095 |
Brugia malayi | hypothetical protein | 0.0176 | 0.1175 | 0.1095 |
Plasmodium falciparum | plasmepsin X | 0.0176 | 0.1175 | 0.2322 |
Schistosoma mansoni | glycogen synthase | 0.143 | 1 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0176 | 0.1175 | 0.1097 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.143 | 1 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0686 | 0.4765 | 0.4718 |
Echinococcus multilocularis | glycogen synthase | 0.143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0584 | 0.405 | 0.4035 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0176 | 0.1175 | 0.1097 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0686 | 0.4765 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0686 | 0.4765 | 0.4752 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0686 | 0.4765 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0686 | 0.4765 | 0.4719 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0176 | 0.1175 | 0.1097 |
Entamoeba histolytica | hypothetical protein | 0.0022 | 0.0087 | 0.5 |
Trypanosoma cruzi | exportin 1, putative | 0.0022 | 0.0089 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0686 | 0.4765 | 0.4719 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1175 | 0.1153 |
Plasmodium falciparum | plasmepsin VII | 0.0176 | 0.1175 | 0.2322 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0176 | 0.1175 | 0.1097 |
Plasmodium falciparum | plasmepsin I | 0.0686 | 0.4765 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.143 | 1 | 1 |
Giardia lamblia | Glycogen synthase, putative | 0.143 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0609 | 0.4221 | 0.417 |
Brugia malayi | Glycogen synthase | 0.0584 | 0.405 | 0.3996 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1175 | 0.1153 |
Echinococcus granulosus | glycogen synthase | 0.143 | 1 | 1 |
Plasmodium vivax | aspartyl protease, putative | 0.0176 | 0.1175 | 0.2322 |
Trichomonas vaginalis | chromosome region maintenance protein, putative | 0.0022 | 0.0089 | 0.0187 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0176 | 0.1175 | 0.2322 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.