Detailed view for TVAG_222470

Basic information

TDR Targets ID: 902936
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 8.6694 | Length (AA): 496 | MW (Da): 58722 | Paralog Number: 9

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02366   Dolichyl-phosphate-mannose-protein mannosyltransferase
PF16192   C-terminal four TMM region of protein-O-mannosyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0000030   mannosyltransferase activity  
GO:0006493   protein amino acid O-linked glycosylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131422)

Species Accession Gene Product
Candida albicans CaO19.12638   similar to dolichyl-P-mannose:protein mannosyltransferase involved in mannosylation of serine and threonine residues
Candida albicans CaO19.5171   similar to dolichyl-P-mannose:protein mannosyltransferase involved in mannosylation of serine and threonine residues
Candida albicans CaO19_5171   hypothetical protein
Saccharomyces cerevisiae YDL095W   Pmt1p
Saccharomyces cerevisiae YDL093W   Pmt5p
Trichomonas vaginalis TVAG_222470   conserved hypothetical protein
Trichomonas vaginalis TVAG_083170   conserved hypothetical protein
Trichomonas vaginalis TVAG_058800   mannosyltransferase 1, putative
Trichomonas vaginalis TVAG_067810   conserved hypothetical protein
Trichomonas vaginalis TVAG_070510   mannosyltransferase 1, putative
Trichomonas vaginalis TVAG_290100   conserved hypothetical protein
Trichomonas vaginalis TVAG_350470   conserved hypothetical protein
Trichomonas vaginalis TVAG_479580   conserved hypothetical protein
Trichomonas vaginalis TVAG_110060   conserved hypothetical protein
Trichomonas vaginalis TVAG_288890   mannosyltransferase 1, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Candida albicans similar to dolichyl-P-mannose:protein mannosyltransferase involved in mannosylation of serine and threonine residues Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1001 0.3783 1
0.1138 0.3283 1
0.1141 0.3189 1
0.1214 1 1
0.1804 0.5295 1
0.1056 0.2979 1
0.1716 0.4027 1
0.207 0.6707 1
0.0994 0.2882 1
0.1716 0.4027 1
0.1001 0.3783 1
0.179 0.3399 1
0.0137 0.5615 0.5615
0.1786 0.474 1
0.0919 0.2636 1
0.207 0.6707 1
0.1378 0.3464 1
0.207 0.6707 1
0.1214 1 1
0.196 1 1
0.0085 0.7113 1
0.1786 0.474 1
0.0085 0.4556 1
0.2403 1 1
0.1221 0.5886 1
0.1141 0.2651 1
0.207 0.6707 1
0.1213 0.7282 1
0.0085 0.5793 1
0.1875 0.4039 1
0.0557 0.336 1
0.1845 0.3821 1
0.1845 0.3821 1
0.1814 0.5126 1
0.1995 0.6011 1
0.0344 1 1
0.1214 1 1
0.1875 0.34 1
0.1876 0.5587 0.743
0.1671 0.4587 1
0.1887 0.4429 1
0.1214 1 1
0.207 0.6707 1
0.1632 0.4721 1
0.1601 0.4418 1
0.1214 1 1
0.1906 0.5673 1
0.1591 0.4587 1
0.1887 0.4429 1
0.1814 0.5126 1
0.1138 0.3283 1
0.1294 0.3651 1
0.1142 0.3178 1
0.0274 0.329 0.9692
0.1845 0.3821 1
0.0347 0.8576 1
0.1671 1 1
0.0415 0.2561 1
0.0139 0.332 1
0.1371 0.3896 1
0.2337 0.6712 1
0.1002 0.28 1
0.1985 0.6706 1
0.1852 1 1
0.1214 1 1
0.0917 0.2605 1
0.1455 0.4036 1
0.1411 0.4019 1
0.1845 0.3821 1
0.0208 0.8922 0.8922
0.1222 0.9872 1
0.207 0.6707 1
0.0975 0.2674 1
0.1556 0.4449 1
0.1001 0.3783 1
0.1141 0.2651 1
0.1845 0.3821 1
0.0913 0.2675 1
0.0912 0.2636 1
0.179 0.2864 1
0.0085 1 1
0.1695 0.4479 1
0.0557 0.3503 1
0.1718 0.5062 1
0.1141 0.2651 1
0.1214 1 1
0.0085 0.3609 1
0.0341 0.4093 0.8626
0.1716 0.4027 1
0.207 0.6707 1
0.207 0.6707 1
0.1716 0.4027 1
0.1687 0.5028 1
0.0085 0.5181 1
0.0342 0.4206 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_222470 (Trichomonas vaginalis), conserved hypothetical protein
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