Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.001 | 0.0197 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0038 | 0.0038 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0197 | 0.1068 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1847 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.5077 | 0.5077 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1847 | 0.1847 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0197 | 0.1068 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.0197 | 0.0197 |
Echinococcus granulosus | smad | 0.001 | 0.0197 | 0.1068 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1847 | 1 |
Schistosoma mansoni | Smad4 | 0.001 | 0.0197 | 0.1068 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.001 | 0.0197 | 0.1068 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0197 | 0.1068 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0038 | 0.0038 |
Brugia malayi | Smad1 | 0.001 | 0.0197 | 0.0197 |
Schistosoma mansoni | smad | 0.001 | 0.0197 | 0.1068 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1847 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.5077 | 0.5077 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1847 | 1 |
Echinococcus multilocularis | smad | 0.001 | 0.0197 | 0.1068 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1847 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.001 | 0.0197 | 0.1068 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.5077 | 0.5077 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | nuclear factor I | 0.0005 | 0.0038 | 0.0038 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1847 | 0.1847 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.0197 | 0.0197 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.001 | 0.0197 | 0.1068 |
Echinococcus granulosus | Smad4 | 0.001 | 0.0197 | 0.1068 |
Echinococcus multilocularis | Smad4 | 0.001 | 0.0197 | 0.1068 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.0197 | 0.0197 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0197 | 0.0197 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1847 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.001 | 0.0197 | 0.1068 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0038 | 0.0038 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0197 | 0.0197 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1847 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.