Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1256 | 0.2505 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.1256 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.1256 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.1256 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1256 | 0.2505 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.1256 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1256 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.1256 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.1256 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.5014 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.1256 | 0.2505 |
Onchocerca volvulus | 0.0043 | 0.1256 | 0.5 | |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.1256 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.1256 | 0.2505 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.5014 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.1256 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.1256 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1256 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1256 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1256 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.1256 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Brugia malayi | beta-lactamase | 0.0043 | 0.1256 | 0.2505 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.1256 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.1256 | 0.5 | |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.1256 | 0.2505 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.5014 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1256 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1256 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.