Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0111 | 0.5333 | 0.2326 |
Loa Loa (eye worm) | tubulin beta chain | 0.0085 | 0.3918 | 0.3918 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0111 | 0.5333 | 0.2326 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0085 | 0.3918 | 0.3918 |
Brugia malayi | Tubulin alpha chain | 0.0085 | 0.3918 | 0.3918 |
Schistosoma mansoni | tar DNA-binding protein | 0.006 | 0.2536 | 0.2018 |
Schistosoma mansoni | tubulin subunit alpha | 0.0085 | 0.3918 | 0.3496 |
Trichomonas vaginalis | tubulin, putative | 0.0111 | 0.5333 | 0.2326 |
Trypanosoma brucei | alpha tubulin, putative | 0.0111 | 0.5333 | 0.2326 |
Brugia malayi | RNA binding protein | 0.006 | 0.2536 | 0.2536 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.006 | 0.2536 | 0.2536 |
Schistosoma mansoni | tar DNA-binding protein | 0.006 | 0.2536 | 0.2018 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0111 | 0.5333 | 0.5333 |
Mycobacterium leprae | cell division protein FtsZ | 0.0085 | 0.3918 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.006 | 0.2536 | 0.2018 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0111 | 0.5333 | 0.2326 |
Schistosoma mansoni | tubulin subunit delta | 0.0085 | 0.3918 | 0.3496 |
Loa Loa (eye worm) | TAR-binding protein | 0.006 | 0.2536 | 0.2536 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0649 | 0.0649 |
Brugia malayi | intermediate filament protein | 0.0025 | 0.0649 | 0.0649 |
Schistosoma mansoni | tar DNA-binding protein | 0.006 | 0.2536 | 0.2018 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0111 | 0.5333 | 0.2326 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0624 | 0.0624 |
Treponema pallidum | cell division protein FtsZ | 0.0085 | 0.3918 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0025 | 0.0649 | 0.0649 |
Loa Loa (eye worm) | RNA binding protein | 0.006 | 0.2536 | 0.2536 |
Schistosoma mansoni | tar DNA-binding protein | 0.006 | 0.2536 | 0.2018 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0025 | 0.0649 | 0.0649 |
Trichomonas vaginalis | tubulin, putative | 0.0111 | 0.5333 | 0.2326 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0111 | 0.5333 | 0.2326 |
Onchocerca volvulus | 0.0111 | 0.5333 | 1 | |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0085 | 0.3918 | 0.5 |
Brugia malayi | Tubulin beta chain | 0.0111 | 0.5333 | 0.5333 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0085 | 0.3918 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3918 | 0.3918 |
Brugia malayi | Tubulin beta chain | 0.0085 | 0.3918 | 0.3918 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0111 | 0.5333 | 0.5333 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0111 | 0.5333 | 0.2326 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5333 | 0.5333 |
Brugia malayi | TAR-binding protein | 0.006 | 0.2536 | 0.2536 |
Schistosoma mansoni | tar DNA-binding protein | 0.006 | 0.2536 | 0.2018 |
Brugia malayi | Cell division protein ftsZ | 0.0085 | 0.3918 | 0.3918 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0111 | 0.5333 | 0.5333 |
Echinococcus multilocularis | tar DNA binding protein | 0.006 | 0.2536 | 0.2018 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0085 | 0.3918 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0025 | 0.0649 | 0.0649 |
Schistosoma mansoni | tubulin subunit beta | 0.0085 | 0.3918 | 0.3496 |
Echinococcus multilocularis | tubulin delta chain | 0.0085 | 0.3918 | 0.3496 |
Brugia malayi | RNA recognition motif domain containing protein | 0.006 | 0.2536 | 0.2536 |
Echinococcus granulosus | tubulin delta chain | 0.0085 | 0.3918 | 0.3496 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 0.33 degrees C | Binding affinity at human recombinant ARTD7 expressed in Escherichia coli BL21 (DE3) R3 pRARE cells assessed as thermal stability shift by differential scanning fluorimetry | ChEMBL. | 22823910 |
Delta Tm (binding) | = 1.63 degrees C | Binding affinity at human recombinant ARTD8 expressed in Escherichia coli BL21 (DE3) R3 pRARE cells assessed as thermal stability shift by differential scanning fluorimetry | ChEMBL. | 22823910 |
IC50 (binding) | = 43 uM | Inhibition of human KLF10 expressed in human HeLa cells assessed as reduction in transcriptional activity after 24 hrs by CACCC-responsive promoter driven TK-luciferase reporter gene assay | ChEMBL. | 25581017 |
Inhibition (binding) | = 25 % | Inhibition of KLF10 (unknown origin) binding to DNA at 8 uM incubated for 4 hrs followed by biotin-labeled probes addition and incubated for another 1 hr by electromobility gel shift assay | ChEMBL. | 25581017 |
Inhibition (binding) | = 83 % | Inhibition of KLF10 (unknown origin) binding to DNA at 50 uM incubated for 4 hrs followed by biotin-labeled probes addition and incubated for another 1 hr by electromobility gel shift assay | ChEMBL. | 25581017 |
Inhibition (binding) | = 85.9 % | Inhibition of human KLF10 expressed in human HeLa cells assessed as reduction in transcriptional activity at 100 uM after 24 hrs by CACCC-responsive promoter driven TK-luciferase reporter gene assay | ChEMBL. | 25581017 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.