Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.1256 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.1256 | 0.5 |
Brugia malayi | beta-lactamase | 0.0041 | 0.1256 | 0.2505 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1256 | 0.2505 |
Onchocerca volvulus | 0.0041 | 0.1256 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.1256 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.1256 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.1256 | 0.2505 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.1256 | 0.5 |
Onchocerca volvulus | 0.0041 | 0.1256 | 0.5 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.1256 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.1256 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.1256 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.5014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1256 | 0.2505 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.1256 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1256 | 0.2505 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.1256 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.1256 | 0.2505 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1256 | 0.2505 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.1256 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.1256 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.1256 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.1256 | 0.2505 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.1256 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.1256 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1256 | 0.2505 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.1256 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.1256 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1256 | 0.2505 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.1256 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.1256 | 0.2505 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.1256 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.5014 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.1256 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.1256 | 0.2505 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.5014 | 1 |
Onchocerca volvulus | 0.0041 | 0.1256 | 0.5 | |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.1256 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 134.09 % | Anticonvulsant activity in NMRI mouse assessed as pentylenetetrazole-induced clonic seizure threshold at 20 mg/kg, ip administered 60 mins before pentylenetetrazole challenge | ChEMBL. | 24530225 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.