Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0104 | 0.5461 | 0.4879 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.4806 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2446 | 0.3302 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0095 | 0.4806 | 0.9611 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.6869 | 0.6385 |
Onchocerca volvulus | 0.0154 | 0.9372 | 1 | |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.4806 | 0.974 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0095 | 0.4806 | 0.3407 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.4902 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0104 | 0.5461 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.4806 | 0.5 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0095 | 0.4806 | 0.3407 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2446 | 0.3302 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0104 | 0.5461 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0096 | 0.4902 | 0.3545 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.4806 | 0.3295 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2446 | 0.3302 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.6869 | 0.6385 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0104 | 0.5461 | 0.4879 |
Brugia malayi | hypothetical protein | 0.0154 | 0.9372 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0104 | 0.5461 | 0.4879 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.4902 | 0.0184 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0096 | 0.4902 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.9372 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0096 | 0.4902 | 0.0184 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0096 | 0.4902 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.6869 | 0.6385 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2446 | 0.3302 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2446 | 0.3302 |
Trypanosoma brucei | polo-like protein kinase | 0.0096 | 0.4902 | 0.0184 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0104 | 0.5461 | 0.1261 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0095 | 0.4806 | 0.9611 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0096 | 0.4902 | 0.3545 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.4902 | 0.0184 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.