Target list

Search results for query: Weighted ranking of Mtb targets based on gene essentiality and expression during persistence for PLOS-NTD

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #8 (Mtu all proteins): 1
  • Score for genes in query #9 (Mtb weighted list for gene attenuation score as in Murphy-Brown data): weighted list
  • Score for genes in query #2 (Hasan 2006 persistence, revised):
  • Score for genes in query #5 (Mtu PDB structures): 20
  • Score for genes in query #10 (Mtb weighted list for persistence expression score as in Murphy-Brown data): weighted list

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

2253 records found | Showing page 90 of 91 (records 2226-2250) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv2563   OG5_153514   Probable glutamine-transport transmembrane protein ABC transporter -1150
M. tuberculosis   Rv0879c   OG5_237764   Possible conserved transmembrane protein -1151
M. tuberculosis   Rv0200   OG5_237834   Possible conserved transmembrane protein -1153
M. tuberculosis   Rv0205   OG5_131504   Probable conserved transmembrane protein -1155
M. tuberculosis   Rv3806c   OG5_155572   Decaprenylphosphoryl-5-phosphoribose (DPPR) synthase (decaprenyl-phosphate 5-pho ... -1158
M. tuberculosis   Rv0935   OG5_131165   Phosphate-transport integral membrane ABC transporter PstC1 -1159
M. tuberculosis   Rv0528   OG5_216151   Probable conserved transmembrane protein -1162
M. tuberculosis   Rv3783   OG5_136920   Probable O-antigen/lipopolysaccharide transport integral membrane protein ABC tr ... -1165
M. tuberculosis   Rv2101   OG5_128804   Probable helicase HelZ -1170
M. tuberculosis   Rv3158   OG5_129510   Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase cha ... -1170
M. tuberculosis   Rv1069c   OG5_191173   Conserved protein -1171
M. tuberculosis   Rv3805c   OG5_237549   Possible arabinofuranosyltransferase AftB -1173
M. tuberculosis   Rv1305   OG5_126818   Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodii ... -1178
M. tuberculosis   Rv1233c   OG5_127406   Conserved hypothetical membrane protein -1183
M. tuberculosis   Rv0996   OG5_237563   Probable conserved transmembrane protein -1197
M. tuberculosis   Rv3155   OG5_130712   Probable NADH dehydrogenase I (chain K) NuoK (NADH-ubiquinone oxidoreductase cha ... -1214
M. tuberculosis   Rv3154   OG5_130964   Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase cha ... -1254
M. tuberculosis   Rv1614   OG5_132435   Possible prolipoprotein diacylglyceryl transferases Lgt -1260
M. tuberculosis   Rv3795   OG5_166834   Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylin ... -1264
M. tuberculosis   Rv0849   OG5_149656   Probable conserved integral membrane transport protein -1666
M. tuberculosis   Rv1500   OG5_127079   Probable glycosyltransferase -1782
M. tuberculosis   Rv0143c   OG5_126837   Probable conserved transmembrane protein -1915
M. tuberculosis   Rv3448     No group ESX conserved component EccD4. ESX-4 type VII secretion system protein. Probable ... -1921
M. tuberculosis   Rv0194   OG5_126596   Probable transmembrane multidrug efflux pump -1985
M. tuberculosis   Rv1671     No group Probable membrane protein -2004

Showing page 90 (records 2226-2250) of 91