Target list

Search results for query: Weighted ranking of Mtb targets based on gene essentiality and expression during persistence for PLOS-NTD

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #9 (Mtb weighted list for gene attenuation score as in Murphy-Brown data): weighted list
  • Score for genes in query #8 (Mtu all proteins): 1
  • Score for genes in query #10 (Mtb weighted list for persistence expression score as in Murphy-Brown data): weighted list
  • Score for genes in query #5 (Mtu PDB structures): 20
  • Score for genes in query #2 (Hasan 2006 persistence, revised):

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

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2253 records found | Showing page 89 of 91 (records 2201-2225) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv0168   OG5_211942   Conserved integral membrane protein YrbE1B -1112
M. tuberculosis   Rv1795   OG5_237703   ESX conserved component EccD5. ESX-5 type VII secretion system protein. Probable ... -1113
M. tuberculosis   Rv0085   OG5_147565   Possible hydrogenase HycP -1114
M. tuberculosis   Rv0286   OG5_173655   PPE family protein PPE4 -1114
M. tuberculosis   Rv0292   OG5_237816   ESX conserved component EccE3. ESX-3 type VII secretion system protein. Probable ... -1116
M. tuberculosis   Rv0513     No group Possible conserved transmembrane protein -1119
M. tuberculosis   Rv0405   OG5_126633   Probable membrane bound polyketide synthase Pks6 -1120
M. tuberculosis   Rv1431   OG5_239130   Conserved membrane protein -1120
M. tuberculosis   Rv2144c   OG5_237636   Probable transmembrane protein -1120
M. tuberculosis   Rv2508c   OG5_133992   Probable conserved integral membrane leucine and alanine rich protein -1121
M. tuberculosis   Rv1824   OG5_193861   Conserved hypothetical membrane protein -1124
M. tuberculosis   Rv0783c   OG5_126664   Possible multidrug resistance integral membrane efflux protein EmrB -1126
M. tuberculosis   Rv3447c   OG5_164917   ESX conserved component EccC4. ESX-4 type VII secretion system protein. Probable ... -1126
M. tuberculosis   Rv2276     No group Cytochrome P450 121 Cyp121 -1127
M. tuberculosis   Rv3355c   OG5_204573   Probable integral membrane protein -1128
M. tuberculosis   Rv3851     No group Possible membrane protein -1130
M. tuberculosis   Rv2195   OG5_196282   Probable rieske iron-sulfur protein QcrA -1133
M. tuberculosis   Rv2196   OG5_128504   Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) -1134
M. tuberculosis   Rv1797   OG5_237701   ESX conserved component EccE5. ESX-5 type VII secretion system protein. Probable ... -1137
M. tuberculosis   Rv2128     No group Conserved transmembrane protein -1140
M. tuberculosis   Rv0463   OG5_237796   Probable conserved membrane protein -1141
M. tuberculosis   Rv0290   OG5_233456   ESX conserved component EccD3. ESX-3 type VII secretion system protein. Probable ... -1144
M. tuberculosis   Rv2156c   OG5_131597   Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX -1147
M. tuberculosis   Rv2802c   OG5_163976   Hypothetical arginine and alanine rich protein -1149
M. tuberculosis   Rv0669c   OG5_129670   Possible hydrolase -1150

Showing page 89 (records 2201-2225) of 91