Target list

Search results for query: Weighted ranking of Pfa targets for PLOS-NTD

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #80 (Mtb mwt <100kDa (now searched on pfa)): 20
  • Score for genes in query #90 (Mtb all proteins (now searched on pfa)): 1
  • Score for genes in query #84 (Mtb not in humans (now searched on pfa)): 25
  • Score for genes in query #82 (Mtb PDB (now searched on pfa)): 50
  • Score for genes in query #89 (Mtb assayable (now searched on pfa)): 35
  • Score for genes in query #85 (Mtb any genetic validation (now searched on pfa)): 50
  • Score for genes in query #87 (Mtb dindex >=0.6 (now searched on pfa)): 35
  • Score for genes in query #79 (Mtb Pubmed (now searched on pfa)): 35
  • Score for genes in query #93 (Pfa in Pvi): 25
  • Score for genes in query #83 (Mtb modbase (now searched on pfa)): 30
  • Score for genes in query #78 (Mtb enz (EC + func. Categ.) (now searched on pfa)): 100
  • Score for genes in query #88 (Mtb Compd desirability >0.3 (now searched on pfa)): 35
  • Score for genes in query #81 (Mtb no TM domain (now searched on pfa)): 20
  • Score for genes in query #86 (Mtb any essentiality evidence (now searched on pfa)): 50

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

4804 records found | Showing page 2 of 193 (records 26-50) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
P. falciparum   PF3D7_0312400   OG5_126888   glycogen synthase kinase 3 386
P. falciparum   PF3D7_0527300   OG5_126721   methionine aminopeptidase 1a, putative 386
P. falciparum   PF3D7_0624000   OG5_126743   hexokinase 386
P. falciparum   PF3D7_0922600   OG5_127086   glutamine synthetase, putative 386
P. falciparum   PF3D7_0923800   OG5_126785   thioredoxin reductase 386
P. falciparum   PF3D7_1115700   OG5_126607   cysteine proteinase falcipain 2a 381
P. falciparum   PF3D7_0907900   OG5_128237   peptide deformylase 381
P. falciparum   PF3D7_0209300   OG5_130616   2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 371
P. falciparum   PF3D7_1033100   OG5_126750   S-adenosylmethionine decarboxylase/ornithine decarboxylase 366
P. falciparum   PF3D7_1128400   OG5_127590   geranylgeranyl pyrophosphate synthase, putative 366
P. falciparum   PF3D7_1324900   OG5_126911   L-lactate dehydrogenase 366
P. falciparum   PF3D7_0206700   OG5_130883   adenylosuccinate lyase 366
P. falciparum   PF3D7_0422000   OG5_126812   steroid dehydrogenase, putative 366
P. falciparum   PF3D7_0514600   OG5_127414   ribose-5-phosphate isomerase, putative 366
P. falciparum   PF3D7_0608800   OG5_126982   ornithine aminotransferase 366
P. falciparum   PF3D7_0922900   OG5_126618   3-oxoacyl-[acyl-carrier-protein] reductase 366
P. falciparum   PF3D7_0928900   OG5_126916   guanylate kinase 366
P. falciparum   PF3D7_1215000   OG5_126593   thioredoxin peroxidase 2 366
P. falciparum   PF3D7_1219900   OG5_127027   ribulose-phosphate 3-epimerase, putative 366
P. falciparum   PF3D7_1008900   OG5_126762   adenylate kinase 351
P. falciparum   PF3D7_1012600   OG5_127152   GMP synthase [glutamine-hydrolyzing] 351
P. falciparum   PF3D7_1129000   OG5_127074   spermidine synthase 351
P. falciparum   PF3D7_1401800   OG5_127835   choline kinase 351
P. falciparum   PF3D7_1419300   OG5_128539   glutathione S-transferase 351
P. falciparum   PF3D7_0406100   OG5_127061   V-type proton ATPase subunit B 351

Showing page 2 (records 26-50) of 193