Target list

Search results for query: Union of (1, 2, 3, 4, 5, 6, 7, 9, 10, 11, 12)

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #9 (amastigote expression >= 1 spectrum): 3
  • Score for genes in query #6 (tcruzi genes essential in bacteria): 50
  • Score for genes in query #5 (tcruzi genes essential in yeast): 50
  • Score for genes in query #2 (tcruzi genes with 3D models): 30
  • Score for genes in query #1 (tcruzi genes with 3D structures): 40
  • Score for genes in query #10 (amastigote expression >= 2 spectra / 2 peptides): 6
  • Score for genes in query #12 (trypomastigote expression >=2 spectra >=2 peptides): 4
  • Score for genes in query #11 (trypomastigote expression >= 1 spectrum): 2
  • Score for genes in query #7 (tcruzi genes with moderately good druggability prediction): 60
  • Score for genes in query #4 (tcruzi genes with orthologs in T. brucei): 40
  • Score for genes in query #3 (tcruzi genes absent in human/mouse): 50

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

18001 records found | Showing page 2 of 721 (records 26-50) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. cruzi   TcCLB.509247.50   OG5_127468   methionyl-tRNA synthetase, putative 186
T. cruzi   TcCLB.507093.260   OG5_126897   ABC transporter, mitochondrial, putative 185
T. cruzi   TcCLB.506211.210   OG5_148499   mitogen-activated protein kinase kinase kinase, putative 185
T. cruzi   TcCLB.511181.80   OG5_126764   threonyl-tRNA synthetase, putative 185
T. cruzi   TcCLB.511289.14   OG5_148499   mitogen-activated protein kinase kinase kinase, putative 185
T. cruzi   TcCLB.509505.50   OG5_126769   10 kDa heat shock protein, putative 185
T. cruzi   TcCLB.511229.50   OG5_127233   S-adenosylhomocysteine hydrolase, putative 185
T. cruzi   TcCLB.508637.150   OG5_127149   ribonuclease L inhibitor, putative 185
T. cruzi   TcCLB.509045.20   OG5_126978   co-chaperone GrpE, putative 185
T. cruzi   TcCLB.505999.100   OG5_161855   3-phosphoglycerate kinase, glycosomal 185
T. cruzi   TcCLB.511589.200   OG5_127233   S-adenosylhomocysteine hydrolase, putative 185
T. cruzi   TcCLB.508209.120   OG5_126769   10 kDa heat shock protein, putative 185
T. cruzi   TcCLB.509505.70   OG5_126769   10 kDa heat shock protein, putative 185
T. cruzi   TcCLB.510889.221   OG5_126980   glucose-6-phosphate isomerase, glycosomal, putative 185
T. cruzi   TcCLB.505999.90   OG5_126776   phosphoglycerate kinase, putative 185
T. cruzi   TcCLB.510123.20   OG5_126781   mitogen-activated protein kinase 11, putative 185
T. cruzi   TcCLB.507929.20   OG5_126978   co-chaperone GrpE, putative 185
T. cruzi   TcCLB.507029.30   OG5_126744   heat shock 70 kDa protein, mitochondrial precursor, putative 185
T. cruzi   TcCLB.511419.40   OG5_126776   phosphoglycerate kinase, putative 185
T. cruzi   TcCLB.508299.80   OG5_126764   threonyl-tRNA synthetase, putative 185
T. cruzi   TcCLB.506943.4   OG5_131364   aldehyde dehydrogenase, putative 183
T. cruzi   TcCLB.507897.30   OG5_142254   serine/threonine-protein kinase a, putative 183
T. cruzi   TcCLB.511301.110   OG5_126887   inosine-5'-monophosphate dehydrogenase, putative 183
T. cruzi   TcCLB.506625.80   OG5_151431   cAMP-specific phosphodiesterase, putative 182
T. cruzi   TcCLB.510661.190   OG5_167795   STE/STE11 serine/threonine-protein kinase, putative 180

Showing page 2 (records 26-50) of 721