Target list

Search results for query: Union of (1, 2, 3, 4, 5, 6, 7, 9, 10, 11, 12)

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #9 (amastigote expression >= 1 spectrum): 3
  • Score for genes in query #12 (trypomastigote expression >=2 spectra >=2 peptides): 4
  • Score for genes in query #10 (amastigote expression >= 2 spectra / 2 peptides): 6
  • Score for genes in query #7 (tcruzi genes with moderately good druggability prediction): 60
  • Score for genes in query #4 (tcruzi genes with orthologs in T. brucei): 40
  • Score for genes in query #5 (tcruzi genes essential in yeast): 50
  • Score for genes in query #1 (tcruzi genes with 3D structures): 40
  • Score for genes in query #11 (trypomastigote expression >= 1 spectrum): 2
  • Score for genes in query #2 (tcruzi genes with 3D models): 30
  • Score for genes in query #3 (tcruzi genes absent in human/mouse): 50
  • Score for genes in query #6 (tcruzi genes essential in bacteria): 50

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

18001 records found | Showing page 3 of 721 (records 51-75) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. cruzi   TcCLB.511301.130   OG5_173466   protein kinase, putative 180
T. cruzi   TcCLB.507991.20   OG5_141398   STE/STE11 serine/threonine-protein kinase, putative 180
T. cruzi   TcCLB.503823.40   OG5_154734   glycosyl hydrolase-like protein, putative 180
T. cruzi   TcCLB.510745.40   OG5_162395   STE20-like serine/threonine-protein kinase 2, putative 180
T. cruzi   TcCLB.506919.90   OG5_133587   protein kinase, putative 180
T. cruzi   TcCLB.503575.60   OG5_154508   CMGC/MAPK protein kinase, putative 180
T. cruzi   TcCLB.510089.80   OG5_131896   protein kinase, putative 180
T. cruzi   TcCLB.506513.160   OG5_127396   polo-like protein kinase, putative 180
T. cruzi   TcCLB.510101.50   OG5_129288   Lanosterol 14-alpha demethylase 180
T. cruzi   TcCLB.511277.140   OG5_146626   CAMK/CAMKL family protein kinase, putative 180
T. cruzi   TcCLB.511021.70   OG5_126733   ABC transporter of the mitochondrion, putative 180
T. cruzi   TcCLB.511417.40   OG5_126694   DNA-directed RNA polymerase III, putative 180
T. cruzi   TcCLB.506801.120   OG5_139200   Calcium/calmodulin-dependent protein kinase kinase, putative 180
T. cruzi   TcCLB.505183.120   OG5_150082   aldo/keto reductase, putative 180
T. cruzi   TcCLB.510329.70   OG5_151756   cdc2-related kinase 10, putative 180
T. cruzi   TcCLB.510323.10   OG5_154473   protein kinase, putative 180
T. cruzi   TcCLB.506477.60   OG5_145823   STE group serine/threonine-protein kinase, putative 180
T. cruzi   TcCLB.510347.60   OG5_146003   calcium/calmodulin-dependent protein kinase, putative 180
T. cruzi   TcCLB.509213.160   OG5_139237   CAMK/CAMKL family protein kinase, putative 180
T. cruzi   TcCLB.511249.60   OG5_130162   CMGC/DYRK protein kinase, putative 180
T. cruzi   TcCLB.508175.80   OG5_148284   STE/STE11 serine/threonine-protein kinase, putative 180
T. cruzi   TcCLB.506349.10   OG5_133587   protein kinase, putative 180
T. cruzi   TcCLB.508153.510   OG5_150111   Serine/threonine-protein kinase NEK6, putative 180
T. cruzi   TcCLB.509105.120   OG5_151810   CMGC family protein kinase, putative 180
T. cruzi   TcCLB.508405.70   OG5_136478   protein kinase, putative 180

Showing page 3 (records 51-75) of 721