Target list

Search results for query: PLoS NTD Query 8 (T. cruzi)

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  • Score for genes in query #10 (tcruzi all genes): 1
  • Score for genes in query #7 (druggability > .5): 60
  • Score for genes in query #13 (tcruzi not in tbrucei): 150
  • Score for genes in query #11 (tcruzi not in humans): 80
  • Imported: from "tcruzi targets shared with leishmania, absent in tbrucei", posted by Fernan Aguero
  • Score for genes in query #12 (tcruzi in leish): 90
  • Score for genes in query #3 (3D structure): 10
  • Score for genes in query #9 (low molecular weight (< 100 kDa)): 25
  • Score for genes in query #8 (bibrefs): 25
  • Score for genes in query #2 (is enzyme): 20
  • Score for genes in query #4 (3D model): 10
  • Score for genes in query #14 (tcruzi reagent availability): 30
  • Score for genes in query #6 (> 3 paralogs): -30
  • Score for genes in query #5 (any evidence of essentiality): 50
  • Score for genes in query #15 (tcruzi assay available): 30
  • Score for genes in query #1 (amastigote expression >= 2 spectra / 2 peptides): 20

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

18628 records found | Showing page 3 of 746 (records 51-75) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. cruzi   TcCLB.510507.40   OG5_129703   transmembrane amino acid transporter, putative 356
T. cruzi   TcCLB.503999.60   OG5_137674   phosphoprotein phosphatase, putative 356
T. cruzi   TcCLB.506989.220   OG5_133292   hypothetical protein, conserved 356
T. cruzi   TcCLB.508951.50   OG5_157932   calmodulin, putative 356
T. cruzi   TcCLB.509713.30   OG5_147206   hypothetical protein, conserved 356
T. cruzi   TcCLB.509065.150   OG5_171037   hypothetical protein, conserved 356
T. cruzi   TcCLB.508207.260   OG5_164625   hypothetical protein, conserved 356
T. cruzi   TcCLB.511509.50   OG5_129101   hypothetical protein, conserved 356
T. cruzi   TcCLB.507509.20   OG5_176574   hypothetical protein, conserved 356
T. cruzi   TcCLB.508461.284   OG5_131022   mitochondrial carrier protein, putative 356
T. cruzi   TcCLB.506247.260   OG5_171945   mitochondrial carrier protein, putative 356
T. cruzi   TcCLB.503599.10   OG5_165260   calcium/calmodulin-dependent protein kinase, putative 356
T. cruzi   TcCLB.509207.150   OG5_144273   kinesin, putative 356
T. cruzi   TcCLB.508199.80   OG5_181890   EF hand, putative 356
T. cruzi   TcCLB.503981.70   OG5_137007   hypothetical protein, conserved 356
T. cruzi   TcCLB.510879.50   OG5_166709   regulatory subunit of protein kinase a-like protein, putative 356
T. cruzi   TcCLB.507585.20   OG5_133292   hypothetical protein, conserved 356
T. cruzi   TcCLB.476421.9   OG5_197818   STE/STE11 serine/threonine-protein kinase, putative 356
T. cruzi   TcCLB.511071.80   OG5_166727   hypothetical protein, conserved 356
T. cruzi   TcCLB.508207.120   OG5_161883   hypothetical protein, conserved 356
T. cruzi   TcCLB.506127.120   OG5_166743   hypothetical protein, conserved 356
T. cruzi   TcCLB.511279.20   OG5_166539   hypothetical protein, conserved 356
T. cruzi   TcCLB.509169.20   OG5_129101   hypothetical protein, conserved 356
T. cruzi   TcCLB.509707.29     No group phosphatidylinositol-4-phosphate 5-kinase-like protein 356
T. cruzi   TcCLB.511051.80   OG5_248282   DNA/RNA non-specific endonuclease protein-like, putative 356

Showing page 3 (records 51-75) of 746