Target list

Search results for query: Weighted list for comparison of PLOS-NTD vs. this prioritization

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #7 (Morphology Defect in C. elegans): 3
  • Score for genes in query #2 (Orthologs of D. melanogaster genes with mutant phenotype lethal): 10
  • Score for genes in query #12 (expressed in adult worm (ESTs)): 3
  • Score for genes in query #19 (Sma uploaded list of targets identified by STARlite search (Berriman et al, 2009)): 10
  • Score for genes in query #16 (Sma all proteins): 1
  • Score for genes in query #18 (Sma uploaded list of metabolic chokepoint enzymes (Berriman et al, 2009)): 10
  • Score for genes in query #15 (expressed in any relevant stage (ESTs)): 10
  • Score for genes in query #34 (top-25 of ranked list for PLOS-NTD; Posted List 336, No tissue-differential gene expression data): 0
  • Score for genes in query #10 (structural model available): 10
  • Score for genes in query #9 (any essentiality evidence): 3
  • Score for genes in query #14 ( expressed in schistosomula stage (ESTs)): 3
  • Score for genes in query #24 (S. mansoni orthologs of C. elegans genes differentially expressed in muscle): 10
  • Score for genes in query #31 (top-100 of ranked list for PLOS-NTD; Posted List 336, No tissue-differential gene expression data): 0
  • Score for genes in query #8 (Sterility in C. elegans): 3
  • Score for genes in query #20 (Sma uploaded list of targets similar to known human targets (Berriman et al, 2009)): 10
  • Score for genes in query #13 ( expressed in egg stage (ESTs)): 3
  • Score for genes in query #5 (Growth Defect in C. elegans): 3
  • Score for genes in query #4 (Embryonic Lethal/Arrest in C. elegans): 10
  • Score for genes in query #1 (Sma EC numbers - uploaded list): 10
  • Score for genes in query #11 (druggable genes inferred by sequence simiarity): 10
  • Score for genes in query #17 (Sma in Cel): 10
  • Score for genes in query #26 (S. mansoni orthologs of C. elegans genes differentially expressed in neurons): 10
  • Score for genes in query #6 (Larval/Adult Lethal/Arrest in C. elegans): 10
  • Score for genes in query #3 (Orthologs of D. melanogaster genes with mutant phenotype neurophysiological defect): 10

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

12680 records found | Showing page 2 of 508 (records 26-50) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
S. mansoni   Smp_130300   OG5_127003   na+/k+ atpase alpha subunit 103
S. mansoni   Smp_106150   OG5_126835   aspartate carbamoyltransferase 103
S. mansoni   Smp_046060.1   OG5_126577   myosin heavy chain type B 102
S. mansoni   Smp_085540.4   OG5_126577   myosin heavy chain 102
S. mansoni   Smp_059340.1   OG5_131088   Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimula ... 102
S. mansoni   Smp_085540.2   OG5_126577   myosin heavy chain 102
S. mansoni   Smp_046060.2   OG5_126577   myosin heavy chain IIb 102
S. mansoni   Smp_085540.1   OG5_126577   myosin heavy chain 102
S. mansoni   Smp_085540.6   OG5_126577   myosin heavy chain 102
S. mansoni   Smp_085540.3   OG5_126577   myosin heavy chain 102
S. mansoni   Smp_106930.2   OG5_126588   heat shock protein 70 102
S. mansoni   Smp_059340.2   OG5_131088   Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimula ... 102
S. mansoni   Smp_106930.1   OG5_126588   heat shock protein 70 102
S. mansoni   Smp_136300   OG5_127750   tyrosine kinase 100
S. mansoni   Smp_128610   OG5_133034   cytochrome-c oxidase 99
S. mansoni   Smp_161920   OG5_126595   actin 99
S. mansoni   Smp_138590   OG5_127955   hydroxymethylglutaryl-CoA reductase (NADPH) 99
S. mansoni   Smp_034490   OG5_127762   proteasome catalytic subunit 1 (T01 family) 99
S. mansoni   Smp_097590   OG5_126723   valine-tRNA ligase 99
S. mansoni   Smp_175090.3   OG5_126601   FAA1 Long-chain-fatty-acid--CoA ligase 1 99
S. mansoni   Smp_056970.2   OG5_126628   glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 99
S. mansoni   Smp_082120   OG5_127404   ATP synthase delta chain mitochondrial 99
S. mansoni   Smp_046600   OG5_126595   actin 99
S. mansoni   Smp_103790   OG5_126605   tubulin subunit alpha 99
S. mansoni   Smp_046590   OG5_126595   actin 99

Showing page 2 (records 26-50) of 508