Target list

Search results for query: Weighted list for comparison of PLOS-NTD vs. this prioritization

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #15 (expressed in any relevant stage (ESTs)): 10
  • Score for genes in query #31 (top-100 of ranked list for PLOS-NTD; Posted List 336, No tissue-differential gene expression data): 0
  • Score for genes in query #34 (top-25 of ranked list for PLOS-NTD; Posted List 336, No tissue-differential gene expression data): 0
  • Score for genes in query #13 ( expressed in egg stage (ESTs)): 3
  • Score for genes in query #1 (Sma EC numbers - uploaded list): 10
  • Score for genes in query #5 (Growth Defect in C. elegans): 3
  • Score for genes in query #4 (Embryonic Lethal/Arrest in C. elegans): 10
  • Score for genes in query #9 (any essentiality evidence): 3
  • Score for genes in query #6 (Larval/Adult Lethal/Arrest in C. elegans): 10
  • Score for genes in query #19 (Sma uploaded list of targets identified by STARlite search (Berriman et al, 2009)): 10
  • Score for genes in query #26 (S. mansoni orthologs of C. elegans genes differentially expressed in neurons): 10
  • Score for genes in query #7 (Morphology Defect in C. elegans): 3
  • Score for genes in query #8 (Sterility in C. elegans): 3
  • Score for genes in query #17 (Sma in Cel): 10
  • Score for genes in query #20 (Sma uploaded list of targets similar to known human targets (Berriman et al, 2009)): 10
  • Score for genes in query #11 (druggable genes inferred by sequence simiarity): 10
  • Score for genes in query #24 (S. mansoni orthologs of C. elegans genes differentially expressed in muscle): 10
  • Score for genes in query #12 (expressed in adult worm (ESTs)): 3
  • Score for genes in query #10 (structural model available): 10
  • Score for genes in query #14 ( expressed in schistosomula stage (ESTs)): 3
  • Score for genes in query #2 (Orthologs of D. melanogaster genes with mutant phenotype lethal): 10
  • Score for genes in query #18 (Sma uploaded list of metabolic chokepoint enzymes (Berriman et al, 2009)): 10
  • Score for genes in query #16 (Sma all proteins): 1
  • Score for genes in query #3 (Orthologs of D. melanogaster genes with mutant phenotype neurophysiological defect): 10

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

12680 records found | Showing page 3 of 508 (records 51-75) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
S. mansoni   Smp_011660.2   OG5_126600   protein kinase 97
S. mansoni   Smp_011660.1   OG5_126600   protein kinase 97
S. mansoni   Smp_011660.3   OG5_126600   protein kinase 97
S. mansoni   Smp_025800   OG5_127834   proteasome subunit beta 1 (T01 family) 96
S. mansoni   Smp_147050   OG5_127237   ATP synthase alpha subunit vacuolar 96
S. mansoni   Smp_079760.1   OG5_132787   protein kinase 96
S. mansoni   Smp_061870   OG5_127574   ubiquinol--cytochrome C reductase 96
S. mansoni   Smp_177420   OG5_132708   hypothetical protein 96
S. mansoni   Smp_052810   OG5_127121   glucose-6-phosphate 1-dehydrogenase 96
S. mansoni   Smp_103160.1   OG5_126601   long-chain-fatty-acid--CoA ligase 96
S. mansoni   Smp_009760   OG5_142874   hypothetical protein 96
S. mansoni   Smp_009780.1   OG5_142874   hypothetical protein 96
S. mansoni   Smp_018260   OG5_129425   glycogen synthase 96
S. mansoni   Smp_170730   OG5_127884   proteasome subunit alpha 1 (T01 family) 96
S. mansoni   Smp_009030   OG5_126839   ribonucleoside-diphosphate reductase alpha subunit 96
S. mansoni   Smp_103160.2   OG5_126601   long-chain-fatty-acid--CoA ligase 96
S. mansoni   Smp_044970   OG5_126779   2-oxoglutarate dehydrogenase 96
S. mansoni   Smp_096270   OG5_126723   valine-tRNA ligase 96
S. mansoni   Smp_009780.2   OG5_142874   hypothetical protein 96
S. mansoni   Smp_072140   OG5_128099   Rho2 GTPase 96
S. mansoni   Smp_099030   OG5_126901   protein kinase 96
S. mansoni   Smp_073410   OG5_127705   proteasome catalytic subunit 2 (T01 family) 96
S. mansoni   Smp_079760.2   OG5_132787   protein kinase 96
S. mansoni   Smp_157090   OG5_131680   subfamily C1A unassigned peptidase (C01 family) 96
S. mansoni   Smp_018890   OG5_126776   phosphoglycerate kinase 93

Showing page 3 (records 51-75) of 508