Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 1 | Starlite/ChEMBL | References |
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.2666 | 0.3087 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0182 | 0.029 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.177 | 0.205 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0112 | 0.3203 | 0.3708 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 0.6264 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.2666 | 0.3087 |
Loa Loa (eye worm) | GMP reductase | 0.0079 | 0.1882 | 0.2179 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0182 | 0.021 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.019 | 0.6264 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.019 | 0.6264 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.177 | 0.205 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0182 | 0.029 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0182 | 0.021 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0034 | 0.013 | 0.0207 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.019 | 0.6264 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 0.6264 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.177 | 0.205 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0178 | 0.5819 | 0.8869 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.177 | 0.205 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.019 | 0.6264 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.019 | 0.6264 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.019 | 0.6264 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0112 | 0.3203 | 0.3708 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.177 | 0.2826 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1432 | 0.1658 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.177 | 0.2826 |
Trichomonas vaginalis | set domain proteins, putative | 0.0284 | 1 | 0.5 |
Onchocerca volvulus | Putative GMP reductase | 0.0079 | 0.1882 | 0.1732 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0182 | 0.029 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.177 | 0.2826 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.177 | 0.205 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.019 | 0.6264 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.019 | 0.6264 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0112 | 0.3203 | 0.3708 |
Toxoplasma gondii | IMP dehydrogenas | 0.019 | 0.6264 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1432 | 0.2286 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.019 | 0.6264 | 0.7253 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0178 | 0.5819 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.019 | 0.6264 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.177 | 0.2826 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.177 | 0.2826 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1432 | 0.1658 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.2666 | 0.3087 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0182 | 0.029 |
Trypanosoma cruzi | GMP reductase | 0.019 | 0.6264 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0249 | 0.8636 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0182 | 0.029 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.019 | 0.6264 | 0.7253 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.01 | 0.2703 | 0.0954 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.019 | 0.6264 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 0.6264 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.019 | 0.6264 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.177 | 0.2826 |
Brugia malayi | GMP reductase | 0.0079 | 0.1882 | 0.2179 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0182 | 0.029 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0079 | 0.1882 | 0.2179 |
Brugia malayi | RNA binding protein | 0.0076 | 0.177 | 0.205 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.019 | 0.6264 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.177 | 0.2826 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0178 | 0.5819 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0079 | 0.1882 | 0.2179 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0249 | 0.8636 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.2666 | 0.3087 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0182 | 0.029 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.