Detailed information for compound 100979

Basic information

Technical information
  • TDR Targets ID: 100979
  • Name: 4-(4-carbamoylphenyl)-N-(2-dimethylaminoethyl )piperazine-1-carboxamide
  • MW: 319.402 | Formula: C16H25N5O2
  • H donors: 2 H acceptors: 2 LogP: 0.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCNC(=O)N1CCN(CC1)c1ccc(cc1)C(=O)N)C
  • InChi: 1S/C16H25N5O2/c1-19(2)8-7-18-16(23)21-11-9-20(10-12-21)14-5-3-13(4-6-14)15(17)22/h3-6H,7-12H2,1-2H3,(H2,17,22)(H,18,23)
  • InChiKey: WSOFTFXUSIGJBD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-carbamoylphenyl)-N-(2-dimethylaminoethyl)-1-piperazinecarboxamide
  • 4-(4-aminocarbonylphenyl)-N-(2-dimethylaminoethyl)piperazine-1-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.0414 0.0399
Trypanosoma brucei glucose transporter 2A 0.0063 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0097 0.404
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0414 0.1769
Leishmania major glucose transporter, lmgt2 0.0063 0.0621 0.868
Brugia malayi hypothetical protein 0.0029 0.0217 0.0894
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0217 0.5239
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.0414 0.5783
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.004 0.0348 0.1536
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0097 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Schistosoma mansoni protein kinase 0.0063 0.0611 0.2648
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0621 0.274
Onchocerca volvulus 0.0029 0.0217 0.5
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0063 0.0611 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0097 0.0427
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0715 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0401 0.1713
Onchocerca volvulus 0.0029 0.0217 0.5
Trypanosoma cruzi hexose transporter 0.0063 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0025 0.0175 0.0709
Schistosoma mansoni glucose transporter 0.0029 0.0217 0.0894
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0097 0.1354
Leishmania major hypothetical protein, conserved 0.0029 0.0217 0.303
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0715 1
Loa Loa (eye worm) sugar transporter 0.0029 0.0217 0.0894
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0063 0.0611 0.855
Loa Loa (eye worm) hypothetical protein 0.005 0.0463 0.1987
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0621 0.868
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0621 0.868
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0097 0.1363
Onchocerca volvulus 0.0029 0.0217 0.5
Leishmania major protein kinase, putative 0.0063 0.0611 0.855
Echinococcus granulosus solute carrier family 22 0.0029 0.0217 0.0894
Onchocerca volvulus 0.0029 0.0217 0.5
Schistosoma mansoni glucose transport protein 0.0205 0.2266 1
Schistosoma mansoni sugar transporter 0.0029 0.0217 0.0894
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0217 0.0894
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0069
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0063 0.0611 0.2648
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0621 0.868
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0097 0.0427
Leishmania major glucose transporter, lmgt1 0.0063 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0063 0.0611 0.2648
Plasmodium falciparum mitogen-activated protein kinase 2 0.0331 0.3734 0.3724
Schistosoma mansoni sugar transporter 0.0029 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0286 0.3994
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0217 0.0894
Echinococcus granulosus solute carrier family 22 0.0029 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0217 0.0894
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.0414 0.6849
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0061 0.0597 0.2634
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Toxoplasma gondii sugar transporter ST3 0.0029 0.0217 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0063 0.0611 0.2648
Echinococcus granulosus General substrate transporter 0.0176 0.193 0.851
Echinococcus multilocularis solute carrier family 22 0.0029 0.0217 0.0894
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0097 0.1398
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0205 0.2266 1
Brugia malayi major facilitator superfamily protein 0.0029 0.0217 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0217 0.0894
Brugia malayi Sugar transporter family protein 0.0029 0.0217 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0715 1
Onchocerca volvulus 0.0029 0.0217 0.5
Plasmodium vivax CDK-related protein kinase 6, putative 0.0868 1 1
Onchocerca volvulus 0.0029 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0097 0.0361
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0715 1
Leishmania major glucose transporter, lmgt3 0.0063 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0217 0.303
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0097 0.1354
Trypanosoma brucei glucose transporter, putative 0.0063 0.0621 0.868
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0401 0.1713
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0611 0.2648
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0621 0.868
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.0414 1
Entamoeba histolytica hypothetical protein 0.0046 0.0414 0.6679
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0217 0.303
Trypanosoma brucei glucose transporter, putative 0.0063 0.0621 0.868
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0134 0.2978
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0097 0.0361
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0217 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0205 0.2266 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0097 0.0081
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0217 0.303
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0621 0.274
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0063 0.0612 0.0597
Plasmodium falciparum calcium-dependent protein kinase 1 0.0063 0.0612 0.0597
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0331 0.3734 0.3724
Entamoeba histolytica protein kinase, putative 0.0063 0.0611 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0401 0.1713
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Plasmodium falciparum calcium-dependent protein kinase 2 0.0063 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Plasmodium falciparum protein kinase 7 0.0578 0.6617 0.6612
Plasmodium falciparum calcium-dependent protein kinase 3 0.0063 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0956
Echinococcus multilocularis solute carrier family 22 0.0029 0.0217 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0063 0.0612 0.0925
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0205 0.2266 1
Onchocerca volvulus 0.0029 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0217 0.0956
Echinococcus multilocularis General substrate transporter 0.0176 0.193 0.851
Onchocerca volvulus 0.0029 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0611 0.2648
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0331 0.3734 0.5643
Plasmodium falciparum proline--tRNA ligase 0.0072 0.0715 0.0701
Leishmania major glucose transporter/membrane transporter D2, putative 0.0063 0.0621 0.868
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0016 0.0468
Echinococcus granulosus solute carrier family 22 0.0029 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0217 0.0894
Schistosoma mansoni hypothetical protein 0.0205 0.2266 1
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0046 0.0414 0.1769
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0217 0.0201
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0414 0.1826
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Onchocerca volvulus 0.0029 0.0217 0.5
Mycobacterium ulcerans sugar transporter 0.0029 0.0217 0.5239
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0061 0.0597 0.9752
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0016 0.0262
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Brugia malayi hypothetical protein 0.0029 0.0217 0.0894
Plasmodium falciparum calcium-dependent protein kinase 5 0.0063 0.0612 0.0597
Loa Loa (eye worm) sugar transporter 0.0205 0.2266 1
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0621 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0956
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0063 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0063 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0217 0.0956
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0061 0.0597 0.2583
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0956
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0217 0.0894
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0217 0.5239
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.0414 0.5783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0401 0.1713
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Giardia lamblia Sugar-proton symporter 0.0029 0.0217 0.346
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0061 0.0597 0.2583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0401 0.1713
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.0414 0.1769
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0333 0.5587
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0061 0.0597 0.2583
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0097 0.1354
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0061 0.0597 0.2583
Onchocerca volvulus 0.0029 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Brugia malayi Cam kinase protein 1 0.0063 0.0611 0.2648
Toxoplasma gondii sugar transporter ST2 0.0029 0.0217 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0401 0.1713
Schistosoma mansoni sugar transporter 0.0029 0.0217 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0621 0.274
Onchocerca volvulus 0.0029 0.0217 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0621 0.274
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.0414 0.0625
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0016 0.0377
Plasmodium vivax calcium-dependent protein kinase, putative 0.0063 0.0612 0.0597
Toxoplasma gondii facilitative glucose transporter GT1 0.0205 0.2266 0.3424
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0134 0.3243
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0097 0.2905
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0217 0.303
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0016 0.0377
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0621 0.274
Plasmodium vivax sugar transporter, putative 0.0029 0.0217 0.0201
Onchocerca volvulus 0.0029 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0621 0.274
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0401 0.1713
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0134 1
Onchocerca volvulus Putative transporter 0.0029 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Schistosoma mansoni ap endonuclease 0.0018 0.0097 0.0361
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.0414 0.0399
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0414 0.1769
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Schistosoma mansoni protein kinase 0.0063 0.0611 0.2648
Giardia lamblia Hexose transporter 0.0029 0.0217 0.346
Brugia malayi hypothetical protein 0.0029 0.0217 0.0894
Schistosoma mansoni ap endonuclease 0.0018 0.0097 0.0361
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0217 0.6499
Echinococcus multilocularis solute carrier family 22 0.0029 0.0217 0.0894
Schistosoma mansoni protein kinase 0.0063 0.0611 0.2648
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.0414 0.6932
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0611 0.2648
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0217 0.5239
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0063 0.0611 0.2648
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0414 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.0333 1
Onchocerca volvulus 0.0029 0.0217 0.5
Brugia malayi Sugar transporter family protein 0.0029 0.0217 0.0894
Echinococcus granulosus solute carrier family 22 0.0029 0.0217 0.0894
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0072 0.0715 0.1081
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0097 0.6855
Plasmodium falciparum calcium-dependent protein kinase 4 0.0063 0.0612 0.0597
Trypanosoma brucei glucose transporter, putative 0.0063 0.0621 0.868
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0205 0.2266 1
Entamoeba histolytica protein kinase, putative 0.0063 0.0611 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0061 0.0597 0.2583
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0061 0.0597 1
Giardia lamblia Prolyl-tRNA synthetase 0.0061 0.0597 1
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0061 0.0597 0.2583
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.0414 0.5783
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0715 1
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0621 0.274
Toxoplasma gondii exonuclease III APE 0.0018 0.0097 0.0146
Onchocerca volvulus 0.0029 0.0217 0.5
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0217 0.303
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0217 0.0956
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0063 0.0612 0.0597
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0205 0.2266 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0061 0.0597 0.2583
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.0414 0.1769
Trypanosoma brucei glucose transporter, putative 0.0063 0.0621 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0217 0.0956
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0205 0.2266 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0097 0.0361
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0097 0.1354
Plasmodium falciparum hexose transporter 0.0205 0.2266 0.2253
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0016 0.0024
Onchocerca volvulus 0.0029 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0217 0.0894
Echinococcus multilocularis calcium dependent protein kinase 0.0059 0.0566 0.2448
Brugia malayi lysyl-tRNA synthetase 0.0046 0.0414 0.1769
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0611 0.2648
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0401 0.1713
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0205 0.2266 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0333 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0611 0.2699
Loa Loa (eye worm) hypothetical protein 0.0061 0.0597 0.2583
Trypanosoma brucei glucose transporter, putative 0.0063 0.0621 0.868
Schistosoma mansoni glucose transport protein 0.0205 0.2266 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0611 0.2648
Brugia malayi major facilitator superfamily protein 0.0029 0.0217 0.0894
Toxoplasma gondii sugar transporter ST1 0.0029 0.0217 0.0327
Trypanosoma brucei sugar transporter, putative 0.0029 0.0217 0.303
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0414 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0611 0.2648
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0097 0.2341
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Schistosoma mansoni glucose transport protein 0.0205 0.2266 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0205 0.2266 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0063 0.0612 0.0925
Trypanosoma brucei glucose transporter, putative 0.0063 0.0621 0.868
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0894
Schistosoma mansoni sugar transporter 0.0029 0.0217 0.0894
Trypanosoma brucei glucose transporter 1E 0.0063 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0063 0.0612 0.0925
Toxoplasma gondii protein kinase, putative 0.0578 0.6617 1
Brugia malayi Sugar transporter family protein 0.0205 0.2266 1
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0611 0.2648
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0611 0.2648
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0217 0.6499
Echinococcus multilocularis solute carrier family 22 0.0029 0.0217 0.0894
Trypanosoma brucei glucose transporter, putative 0.0063 0.0621 0.868
Plasmodium vivax hexose transporter 0.0205 0.2266 0.2253
Echinococcus granulosus calcium dependent protein kinase 0.0059 0.0566 0.2448
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956
Plasmodium vivax proline--tRNA ligase, putative 0.0072 0.0715 0.0701
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0401 0.1713
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0097 0.0361
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0217 0.0327
Onchocerca volvulus 0.0029 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0217 0.0956

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = 0 % Oral antiallergic activity in rat passive foot anaphylaxis (PFA) assay as percent change in volume of foot edema at a dose 31.6 mg/kg compared to -80% of aminophylline at 100 mg/kg ChEMBL. 1972965

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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