TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 345.393 | Formula: C18H23N3O4
H donors: 2 H acceptors: 4 LogP: 2.59 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCC[C@@H](C(=O)N1CCC[C@H]1c1nc2c(o1)cccc2)C(=O)NO
InChi: 1S/C18H23N3O4/c1-2-3-7-12(16(22)20-24)18(23)21-11-6-9-14(21)17-19-13-8-4-5-10-15(13)25-17/h4-5,8,10,12,14,24H,2-3,6-7,9,11H2,1H3,(H,20,22)/t12-,14+/m1/s1
InChiKey: BDPQRVOASIZZQP-OCCSQVGLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium falciparum	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium knowlesi	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium yoelii	polypeptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	Get druggable targets OG5_128237	All targets in OG5_128237
Treponema pallidum	polypeptide deformylase (def)	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium vivax	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Chlamydia trachomatis	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium berghei	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	Get druggable targets OG5_128237	All targets in OG5_128237
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128237	All targets in OG5_128237
Neospora caninum	Peptide deformylase, related	Get druggable targets OG5_128237	All targets in OG5_128237

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	surface protease GP63, putative	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	197 aa	171 aa	25.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0259	0.2737	1
Trypanosoma brucei	Peptide deformylase 2	0.0106	0.0925	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0188	0.0368
Plasmodium vivax	peptide deformylase, putative	0.0279	0.2966	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0081	0.0367
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0188	0.0595
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0238	0.0826
Echinococcus granulosus	RUN	0.0039	0.0127	0.0572
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.2737	1
Brugia malayi	Ets-domain containing protein	0.0074	0.0537	0.1926
Brugia malayi	Doublecortin family protein	0.0039	0.0127	0.0418
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0091	0.0341
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0061	0.0389	0.1637
Trypanosoma cruzi	metacaspase, putative	0.0044	0.0188	0.1167
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1681	0.6008
Schistosoma mansoni	caspase-7 (C14 family)	0.0085	0.0675	0.2882
Echinococcus multilocularis	GA binding protein alpha chain	0.0074	0.0537	0.0525
Onchocerca volvulus		0.0039	0.0127	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0188	0.0645
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1681	0.6008
Onchocerca volvulus		0.0233	0.242	1
Schistosoma mansoni	loxhd1	0.0039	0.0127	0.0496
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0044	0.0188	0.0368
Echinococcus granulosus	apoptotic protease activating factor 1	0.0041	0.0153	0.0688
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0136	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0188	0.0368
Trypanosoma brucei	metacaspase MCA2	0.0044	0.0188	0.1167
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0188	0.0368
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0153	0.1474	0.5365
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.004	0.0136	0.0539
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.004	0.0136	0.0539
Loa Loa (eye worm)	fli-1 protein	0.0224	0.2312	0.844
Brugia malayi	Coelomocyte uptake defective protein 5	0.0068	0.0472	0.1686
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0091	0.0288
Brugia malayi	beta-lactamase family protein	0.0036	0.0091	0.0288
Brugia malayi	hypothetical protein	0.0041	0.0153	0.0513
Schistosoma mansoni	ap endonuclease	0.004	0.0136	0.0536
Trypanosoma brucei	Polypeptide deformylase 1	0.0106	0.0925	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0081	0.0298
Brugia malayi	Cell death protein 3 precursor	0.0085	0.0675	0.2432
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0044	0.0188	0.0368
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0039	0.0127	0.0114
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0106	0.0925	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0127	0.0418
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1681	0.6008
Brugia malayi	follicle stimulating hormone receptor	0.0235	0.2453	0.8958
Echinococcus multilocularis	caspase 8	0.0044	0.0188	0.0176
Brugia malayi	latrophilin 2 splice variant baaae	0.0104	0.0902	0.3264
Trypanosoma brucei	metacaspase	0.0044	0.0188	0.1167
Echinococcus granulosus	neuropeptide receptor	0.0215	0.2216	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.004	0.0136	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0127	0.0496
Onchocerca volvulus		0.0039	0.0127	0.0473
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0106	0.0925	1
Onchocerca volvulus		0.0036	0.0091	0.0326
Toxoplasma gondii	exonuclease III APE	0.004	0.0136	0.0418
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.2737	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0091	0.0288
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0091	0.0079
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0238	0.0826
Loa Loa (eye worm)	mucolipin 1	0.0068	0.0472	0.1686
Brugia malayi	Fli-1 protein	0.0224	0.2312	0.844
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0238	0.0225
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0061	0.0389	0.1037
Schistosoma mansoni	gabp alpha	0.0074	0.0537	0.2282
Trypanosoma cruzi	metacaspase, putative	0.0044	0.0188	0.1167
Echinococcus multilocularis	neuropeptide receptor	0.0215	0.2216	0.2206
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0238	0.0225
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0061	0.0389	0.1037
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0188	0.0368
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0235	0.2453	0.8958
Plasmodium vivax	metacaspase 1, putative	0.0044	0.0188	0.0595
Schistosoma mansoni	lipoxygenase	0.0109	0.0957	0.4105
Schistosoma mansoni	caspase-7 (C14 family)	0.0117	0.1048	0.4502
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0044	0.0188	0.0764
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0044	0.0188	0.0595
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0091	0.0288
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.2737	1
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1681	0.6008
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0902	0.3264
Brugia malayi	hypothetical protein	0.0035	0.0081	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0091	0.0288
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0153	0.1474	0.5365
Echinococcus granulosus	caspase 3	0.0073	0.0525	0.237
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0081	0.0069
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0044	0.0188	0.0368
Echinococcus granulosus	Polycystic kidney disease protein	0.0045	0.0194	0.0876
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0091	0.0411
Echinococcus granulosus	GPCR family 2	0.0048	0.0238	0.1074
Schistosoma mansoni	rab6-interacting	0.0039	0.0127	0.0496
Trypanosoma cruzi	metacaspase, putative	0.0044	0.0188	0.1167
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0117	0.1048	0.1037
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0091	0.0288
Plasmodium vivax	multidomain scavenger receptor, putative	0.0039	0.0127	0.0386
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0106	0.0925	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0053	0.0298	0.1047
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.179	0.6418
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0411	0.1462
Schistosoma mansoni	hypothetical protein	0.0041	0.0153	0.0608
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0044	0.0188	0.0595
Echinococcus granulosus	lipoxygenase domain containing protein	0.0039	0.0127	0.0572
Trypanosoma cruzi	metacaspase 5, putative	0.0044	0.0188	0.1167
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0136	0.0418
Toxoplasma gondii	ABC1 family protein	0.0036	0.0091	0.0266
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0091	0.0288
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0238	0.1074
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0044	0.0188	0.0368
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.2737	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0061	0.0389	0.1037
Echinococcus granulosus	caspase 8	0.0044	0.0188	0.085
Echinococcus multilocularis	Polycystic kidney disease protein	0.0045	0.0194	0.0182
Trypanosoma brucei	Metacaspase-4	0.0044	0.0188	0.1167
Schistosoma mansoni	hypothetical protein	0.0048	0.0238	0.0979
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0044	0.0188	0.0595
Toxoplasma gondii	hypothetical protein	0.0279	0.2966	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.004	0.0136	0.0614
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.179	0.6418
Plasmodium falciparum	metacaspase 1	0.0044	0.0188	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0091	0.0288
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0091	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0091	0.0288
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0259	0.2737	1
Leishmania major	polypeptide deformylase-like protein, putative	0.0106	0.0925	1
Echinococcus multilocularis	caspase 3	0.0073	0.0525	0.0513
Brugia malayi	Pre-SET motif family protein	0.0204	0.2086	0.7609
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.023	0.2384	0.7977
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.004	0.0136	0.5
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0136	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0091	0.0288
Schistosoma mansoni	mucolipin	0.0062	0.0405	0.1704
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.004	0.0136	0.0156
Onchocerca volvulus	Glucosylceramidase homolog	0.017	0.1681	0.693
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1681	0.6008
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0153	0.1474	0.5365
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0238	0.0826
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0238	0.0826
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.004	0.0136	0.0539
Trypanosoma brucei	metacaspase 5, putative	0.0044	0.0188	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0675	0.2432
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0061	0.0389	0.1382
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0044	0.0188	0.0368
Schistosoma mansoni	lipoxygenase	0.0039	0.0127	0.0496
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0044	0.0188	0.0645
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.2737	1
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0279	0.2966	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.004	0.0136	0.0539
Trypanosoma cruzi	metacaspase 5, putative	0.0044	0.0188	0.1167
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0109	0.0957	0.4317
Schistosoma mansoni	hypothetical protein	0.0048	0.0238	0.0979
Plasmodium falciparum	peptide deformylase	0.0279	0.2966	1
Onchocerca volvulus	Cell death protein 3 homolog	0.0085	0.0675	0.2753
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0279	0.2966	1
Brugia malayi	Ets-domain containing protein	0.0074	0.0537	0.1926
Echinococcus multilocularis	RUN	0.0039	0.0127	0.0114
Leishmania major	metacaspase, putative	0.0044	0.0188	0.1167
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0074	0.0537	0.1926
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1681	0.6008
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1474	0.5365
Mycobacterium ulcerans	peptide deformylase	0.0279	0.2966	1
Echinococcus multilocularis	caspase 2	0.0085	0.0675	0.0663
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0013	0.0058
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0061	0.0389	0.1757
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0061	0.0389	0.3575
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0039	0.0127	0.0114
Schistosoma mansoni	polycystin 1-related	0.0045	0.0194	0.0789
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0044	0.0188	0.0368
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.004	0.0136	0.0124
Schistosoma mansoni	hypothetical protein	0.0048	0.0238	0.0979
Plasmodium falciparum	metacaspase-like protein	0.0044	0.0188	0.0217
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0136	0.017
Loa Loa (eye worm)	doublecortin family protein	0.0039	0.0127	0.0418
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0061	0.0389	0.0377
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.2086	0.7609
Echinococcus multilocularis	caspase	0.0117	0.1048	0.1037
Echinococcus granulosus	mucolipin 3	0.0068	0.0472	0.213
Brugia malayi	hypothetical protein	0.0039	0.0127	0.0418
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0044	0.0188	0.0368
Schistosoma mansoni	neuropeptide receptor	0.0215	0.2216	0.9582
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1681	0.6008
Brugia malayi	hypothetical protein	0.0039	0.0127	0.0418
Schistosoma mansoni	hypothetical protein	0.0104	0.0902	0.3867
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0041	0.0153	0.014
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0117	0.1048	0.4729
Onchocerca volvulus		0.0036	0.0091	0.0326
Schistosoma mansoni	caspase-3 (C14 family)	0.0117	0.1048	0.4502
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0044	0.0188	0.0368
Echinococcus multilocularis	mucolipin 3	0.0068	0.0472	0.046
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0091	0.0341
Treponema pallidum	polypeptide deformylase (def)	0.0279	0.2966	1
Echinococcus granulosus	caspase 2	0.0085	0.0675	0.3048
Echinococcus granulosus	GA binding protein alpha chain	0.0074	0.0537	0.2425
Onchocerca volvulus		0.0036	0.0091	0.0326
Onchocerca volvulus		0.0041	0.0153	0.0581
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0238	0.0225
Trypanosoma cruzi	metacaspase, putative	0.0044	0.0188	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0127	0.0418
Chlamydia trachomatis	peptide deformylase	0.0279	0.2966	0.5
Echinococcus granulosus	caspase	0.0117	0.1048	0.4729
Brugia malayi	beta-lactamase	0.0036	0.0091	0.0288
Brugia malayi	exodeoxyribonuclease III family protein	0.004	0.0136	0.0453
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0081	0.0298
Echinococcus multilocularis	G protein coupled receptor 139	0.0215	0.2216	0.2206
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0279	0.2966	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0091	0.0288
Schistosoma mansoni	hypothetical protein	0.0048	0.0238	0.0979
Schistosoma mansoni	ap endonuclease	0.004	0.0136	0.0536
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.242	0.8801
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.2737	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0188	0.0368
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0106	0.0925	1
Schistosoma mansoni	rab6-interacting	0.0039	0.0127	0.0496
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0109	0.0957	0.0945
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0238	0.1074
Schistosoma mansoni	ets-related	0.0224	0.2312	1
Trypanosoma brucei	metacaspase MCA3	0.0044	0.0188	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0153	0.0513
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0044	0.0188	0.0368
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.004	0.0136	0.0156
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.004	0.0136	0.0453
Schistosoma mansoni	mucolipin	0.0068	0.0472	0.1997
Echinococcus granulosus	lipoxygenase domain containing protein	0.0039	0.0127	0.0572
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0188	0.0368

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.049 uM	Inhibition of Mycobacterium tuberculosis peptide deformylase expressed in Escherichia coli M15(pREp4) by microplate assay	ChEMBL.	19008098

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL517164

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1013589