Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0059 | 0.0273 | 0.0471 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0136 | 0.3195 | 0.5 |
Onchocerca volvulus | 0.0136 | 0.3195 | 1 | |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.0537 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0537 | 0.0537 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0136 | 0.3195 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0059 | 0.0273 | 0.0853 |
Brugia malayi | acyl-CoA desaturase | 0.0136 | 0.3195 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0059 | 0.0273 | 0.0853 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0134 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0537 | 0.0928 |
Brugia malayi | MAP kinase sur-1 | 0.0056 | 0.0134 | 0.0421 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0059 | 0.0273 | 0.0471 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0056 | 0.0134 | 0.0232 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0537 | 0.5 |
Onchocerca volvulus | 0.0136 | 0.3195 | 1 | |
Leishmania major | stearic acid desaturase, putative | 0.0136 | 0.3195 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0059 | 0.0273 | 0.0471 |
Echinococcus granulosus | geminin | 0.0185 | 0.5025 | 0.868 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0134 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0056 | 0.0134 | 0.0421 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0136 | 0.3195 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0537 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.0537 | 0.1317 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0056 | 0.0134 | 0.0232 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0134 | 0.5 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0205 | 0.579 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0056 | 0.0134 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0273 | 0.0853 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0059 | 0.0273 | 0.0273 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0537 | 0.0928 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.0134 | 0.0134 |
Echinococcus multilocularis | geminin | 0.0185 | 0.5025 | 0.868 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0134 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0537 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0537 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0537 | 0.0537 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0056 | 0.0134 | 0.5 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0205 | 0.579 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0136 | 0.3195 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.5025 | 0.5025 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.5025 | 0.5025 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0136 | 0.3195 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0136 | 0.3195 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.0136 | 0.3195 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0136 | 0.3195 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0059 | 0.0273 | 0.0471 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0056 | 0.0134 | 0.0232 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4600 nM | Inhibition of Delta-9-desaturase in human HepG2 cells | ChEMBL. | 19249203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.