Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.7978 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4087 | 0.4413 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0947 | 0.1188 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0947 | 0.1287 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.0106 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.9262 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4417 | 0.4769 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.3258 | 0.4427 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0435 | 0.0592 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0618 | 0.0774 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0435 | 0.0592 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.3258 | 0.4427 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0947 | 0.1287 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0435 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3679 | 0.3972 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.3667 | 0.2673 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.736 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0618 | 0.0667 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 10 % | Displacement of [3H]GR-113808 from human 5HT4 isoform E receptor expressed in rat C6 cells at 10 nM by liquid scintillation counting | ChEMBL. | 19334715 |
Emax (functional) | = 10 % | Agonist activity at human 5HT4 isoform E receptor expressed in rat C6 cells assessed as cAMP accumulation at 10 nM by radio-immunoassay relative to 5HT | ChEMBL. | 19334715 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.