Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0002 | 0.0003 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0002 | 0.002 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0075 | 0.0087 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0142 | 0.0506 | 0.0876 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0002 | 0.002 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0142 | 0.0506 | 0.0591 |
Loa Loa (eye worm) | hypothetical protein | 0.1439 | 0.5464 | 0.9454 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0428 | 0.0741 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.021 | 0.0245 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.0506 | 0.0591 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0813 | 0.3073 | 0.3584 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0071 | 0.0083 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.0735 | 0.1272 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.1439 | 0.5464 | 0.9454 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.1522 | 0.578 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.2252 | 0.8573 | 0.803 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.021 | 0.0364 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0002 | 0.0002 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.1522 | 0.578 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0002 | 0.0002 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.0506 | 0.0591 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2626 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0002 | 0.0003 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0002 | 0.002 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0075 | 0.0087 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.021 | 0.0364 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.023 | 0.0842 | 1 | |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0002 | 0.0002 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.2252 | 0.8573 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.0735 | 0.0858 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0428 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0428 | 0.05 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0708 | 0.2672 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0002 | 0.0002 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.5 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2626 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.2252 | 0.8573 | 0.803 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.1439 | 0.5464 | 0.6374 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0708 | 0.2672 | 0.5 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0813 | 0.3073 | 0.2886 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0075 | 0.0129 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0075 | 0.0087 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.021 | 0.0245 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0002 | 0.0003 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0075 | 0.0087 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0075 | 0.0087 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.2252 | 0.8573 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.2252 | 0.8573 | 0.803 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.021 | 0.0245 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.1439 | 0.5464 | 0.9454 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2626 | 1 | 1 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.2252 | 0.8573 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0029 | 0.0075 | 0.0889 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0002 | 0.0003 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0075 | 0.0087 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.0731 | 0.2757 | 0.3216 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.001 | 0.0002 | 0.002 | |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | RNA binding protein | 0.0064 | 0.021 | 0.0245 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0075 | 0.0087 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.0506 | 0.0591 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.0506 | 0.0591 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0506 | 0.0591 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.021 | 0.0245 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.021 | 0.0364 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0075 | 0.0087 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.1439 | 0.5464 | 0.6374 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.2252 | 0.8573 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0002 | 0.0002 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.2252 | 0.8573 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.1439 | 0.5464 | 0.5979 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0002 | 0.0003 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0002 | 0.0002 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0506 | 0.0591 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0506 | 0.0591 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0002 | 0.0002 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.1439 | 0.5464 | 0.5979 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.