Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0659 | 0.0646 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0004 | 0.0013 | 0.0013 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0065 | 0.247 | 0.246 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0253 | 1 | 1 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0013 | 0.0013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0232 | 0.0219 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0227 | 0.0214 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.4484 | 0.4477 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0157 | 0.0144 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0659 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0157 | 0.0144 |
Echinococcus multilocularis | smad | 0.0008 | 0.0166 | 0.0153 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0166 | 0.0153 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0659 | 0.0646 |
Schistosoma mansoni | smad | 0.0008 | 0.0166 | 0.0153 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0166 | 0.0153 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Echinococcus granulosus | smad | 0.0008 | 0.0166 | 0.0153 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.1156 | 0.1144 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0659 | 1 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0253 | 1 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0253 | 1 | 1 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0004 | 0.0013 | 0.0013 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.1156 | 0.1144 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0004 | 0.0013 | 0.0013 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.013 | 0.013 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0024 | 0.0011 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0659 | 0.0646 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0659 | 0.0646 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.1085 | 0.1073 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0659 | 0.0646 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0659 | 0.0646 |
Echinococcus multilocularis | geminin | 0.0182 | 0.7138 | 0.7134 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0166 | 0.0153 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0027 | 0.0014 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | nuclear factor I | 0.0004 | 0.0024 | 0.0011 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.7138 | 0.7134 |
Brugia malayi | Smad1 | 0.0008 | 0.0166 | 0.0153 |
Onchocerca volvulus | 0.0031 | 0.1085 | 1 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.219 | 0.218 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0013 | 0.0013 |
Brugia malayi | MH1 domain containing protein | 0.0004 | 0.0024 | 0.0011 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0166 | 0.0153 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0232 | 0.0219 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0013 | 0.0013 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0253 | 1 | 1 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0004 | 0.0013 | 0.0013 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0157 | 0.0144 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0659 | 0.0659 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.1156 | 0.1144 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0166 | 0.0153 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0166 | 0.0153 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.7138 | 0.7134 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0253 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.4484 | 0.4477 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0253 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.016 | 0.6275 | 0.627 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0659 | 0.0646 |
Echinococcus multilocularis | muscleblind protein | 0.016 | 0.6275 | 0.627 |
Brugia malayi | Muscleblind-like protein | 0.016 | 0.6275 | 0.627 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0659 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0659 | 0.0646 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0166 | 0.0153 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0659 | 0.0646 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0253 | 1 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0253 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0659 | 0.0646 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0253 | 1 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0253 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0253 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0659 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0166 | 0.0153 |
Brugia malayi | MH1 domain containing protein | 0.0004 | 0.0024 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.6275 | 0.627 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0253 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0166 | 0.0153 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0166 | 0.0153 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0157 | 0.0144 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0659 | 0.0646 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0166 | 0.0153 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.013 | 0.013 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.013 | 0.013 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0659 | 0.0646 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.1085 | 0.1073 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.6275 | 0.627 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0157 | 0.0144 |
Echinococcus multilocularis | muscleblind protein 1 | 0.016 | 0.6275 | 0.627 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0659 | 0.0646 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0253 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.1156 | 0.1144 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.1085 | 0.1073 |
Echinococcus granulosus | geminin | 0.0182 | 0.7138 | 0.7134 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0253 | 1 | 1 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0004 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.4484 | 0.4477 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0659 | 0.0659 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0004 | 0.0013 | 0.0013 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0166 | 0.0153 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0232 | 0.0219 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0166 | 0.0153 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0659 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0659 | 0.0646 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Contraction (functional) | % | Agonism of Muscarinic acetylcholine receptor M3 was determined as maximal contraction rate of isolated guinea pig ileum | ChEMBL. | 15149637 |
Relaxation (functional) | = 10 % | Agonism of endothelin A receptor was determined as maximal rate of vascular endothelium-dependent relaxation at the concentration of 10E-5 M/L; 0-10% | ChEMBL. | 15149637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.