Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.005 | 0.0998 | 0.5 | |
Trypanosoma brucei | nucleoside 2-deoxyribosyltransferase | 0.0263 | 0.8315 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0998 | 0.0097 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0244 | 0.7681 | 1 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0067 | 0.1593 | 0.5 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.0067 | 0.1593 | 0.1009 |
Trypanosoma cruzi | hypothetical protein | 0.0263 | 0.8315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.7681 | 0.7639 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0998 | 0.0097 |
Brugia malayi | MH2 domain containing protein | 0.0241 | 0.7557 | 0.7512 |
Trypanosoma cruzi | hypothetical protein | 0.0263 | 0.8315 | 1 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.0067 | 0.1593 | 0.1438 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0181 | 1 |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.0067 | 0.1593 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0181 | 0.0218 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0241 | 0.7557 | 0.7512 |
Echinococcus multilocularis | geminin | 0.0173 | 0.5238 | 0.6392 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0181 | 1 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.0067 | 0.1593 | 0.0751 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.5238 | 0.4762 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0181 | 1 |
Schistosoma mansoni | glutaminase | 0.0312 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0181 | 0.0218 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0998 | 0.0833 |
Echinococcus granulosus | geminin | 0.0173 | 0.5238 | 0.6392 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.0067 | 0.1593 | 0.1009 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.091 | 0.0743 |
Loa Loa (eye worm) | glutaminase | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0241 | 0.7557 | 0.7512 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.091 | 0.0743 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.5238 | 0.4762 |
Leishmania major | hypothetical protein, conserved | 0.0263 | 0.8315 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0048 | 0.095 | 0.095 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0181 | 0.0218 |
Trichomonas vaginalis | glutaminase, putative | 0.0312 | 1 | 1 |
Brugia malayi | Ectopic membrane ruffles in embryo protein 1 | 0.0067 | 0.1593 | 0.1438 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0181 | 0.0218 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0244 | 0.7681 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0263 | 0.8315 | 1 |
Brugia malayi | hypothetical protein | 0.0244 | 0.7681 | 0.7639 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0263 | 0.8315 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0263 | 0.8315 | 0.8315 |
Mycobacterium ulcerans | glutaminase | 0.0312 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0263 | 0.8315 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0312 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.