Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.0135 | 0.5439 | 0.8116 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.092 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0147 | 0.6028 | 0.6028 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.0505 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0147 | 0.6028 | 0.9087 |
Onchocerca volvulus | 0.0091 | 0.3258 | 1 | |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.092 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0157 | 0.6514 | 0.6514 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0147 | 0.6028 | 0.5817 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0505 | 0.0505 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1078 | 0.0942 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0143 | 0.5825 | 0.5603 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0146 | 0.5934 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.0098 | 0.0098 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.092 | 0.0437 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0743 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1078 | 0.0942 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.092 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0505 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0157 | 0.6514 | 0.6329 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0743 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.092 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.0505 | 1 |
Schistosoma mansoni | d-amino acid oxidase | 0.0159 | 0.6584 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0743 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0135 | 0.5439 | 0.8116 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1078 | 0.1078 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0505 | 0.5494 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0157 | 0.6514 | 0.6329 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 1 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.092 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0157 | 0.6514 | 0.6514 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0159 | 0.6584 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0157 | 0.6514 | 0.6329 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.6584 | 0.6584 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.0098 | 0.0098 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0147 | 0.6028 | 0.6028 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0159 | 0.6584 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0505 | 0.0505 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0505 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 10000 nM | Agonist activity at PR expressed in african green monkey CV-1 cells by luciferase reporter assay | ChEMBL. | 19595590 |
IC50 (binding) | = 1300 nM | Binding affinity to PR by fluorescence polarization based competition binding assay | ChEMBL. | 19595590 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.