Detailed information for compound 1041183

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 309.795 | Formula: C14H20ClN5O
  • H donors: 4 H acceptors: 2 LogP: 1.81 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccccc1)NCCCc1c[nH]c(n1)N.Cl
  • InChi: 1S/C14H19N5O.ClH/c15-13-17-10-12(19-13)7-4-8-16-14(20)18-9-11-5-2-1-3-6-11;/h1-3,5-6,10H,4,7-9H2,(H3,15,17,19)(H2,16,18,20);1H
  • InChiKey: YPEVZNJCBHKTQG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Entamoeba histolytica hypothetical protein 0.0023 0.0149 0.2021
Schistosoma mansoni glucose transport protein 0.0212 0.2276 0.59
Leishmania major importin beta-1 subunit, putative 0.0023 0.0149 0.1902
Leishmania major hypothetical protein, conserved 0.003 0.023 0.303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0397 0.0965
Trypanosoma brucei glucose transporter 1E 0.0066 0.0634 0.8705
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0209 0.0471
Echinococcus granulosus importin subunit beta 1 0.0028 0.0209 0.0471
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0625 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0634 0.274
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.01 0.1185
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0029 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0634 0.274
Mycobacterium ulcerans sugar transporter 0.003 0.023 0.5239
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0162
Echinococcus multilocularis geminin 0.0351 0.3838 1
Onchocerca volvulus 0.003 0.023 0.5
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0427 1
Echinococcus multilocularis solute carrier family 22 0.003 0.023 0.0527
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.01 0.0381
Onchocerca volvulus 0.003 0.023 0.5
Echinococcus multilocularis GPCR, family 2 0.0017 0.0091 0.0162
Schistosoma mansoni ran 0.0021 0.0126 0.0254
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0149 0.06
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0397 0.0965
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0397 0.0965
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0609 0.2634
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0624 0.8577
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.01 0.0071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0091 0.0162
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.3242 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.01 0.1205
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.023 0.316
Echinococcus granulosus solute carrier family 22 0.003 0.023 0.0527
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.023 0.5239
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.023 1
Brugia malayi Major Facilitator Superfamily protein 0.003 0.023 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0634 0.8705
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2276 0.59
Toxoplasma gondii sugar transporter ST1 0.003 0.023 0.0327
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Echinococcus multilocularis snurportin 1 0.0298 0.3242 0.8435
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2276 0.59
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.023 0.0956
Onchocerca volvulus 0.003 0.023 0.5
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Plasmodium vivax CDK-related protein kinase 6, putative 0.09 1 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0609 0.2583
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0634 0.274
Onchocerca volvulus 0.003 0.023 0.5
Trichomonas vaginalis sugar transport protein, putative 0.003 0.023 0.0956
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0318 0.1284
Trichomonas vaginalis conserved hypothetical protein 0.003 0.023 0.0956
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0625 0.0597
Brugia malayi Cam kinase protein 1 0.0065 0.0624 0.2648
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0147 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0624 0.1563
Trichomonas vaginalis conserved hypothetical protein 0.003 0.023 0.0956
Onchocerca volvulus 0.003 0.023 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.01 0.0185
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0427 0.1044
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.01 0.1215
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0091 0.0274
Schistosoma mansoni hypothetical protein 0.0038 0.0318 0.0757
Echinococcus multilocularis tar DNA binding protein 0.007 0.068 0.171
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.023 0.0527
Brugia malayi RNA binding protein 0.007 0.068 0.2898
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0029 0.0069
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0427 1
Trypanosoma brucei glucose transporter, putative 0.0066 0.0634 0.8705
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Toxoplasma gondii facilitative glucose transporter GT1 0.0212 0.2276 0.3424
Loa Loa (eye worm) hypothetical protein 0.0052 0.0476 0.139
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0347 1
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0634 0.274
Trypanosoma cruzi hexose transporter, putative 0.003 0.023 0.303
Onchocerca volvulus 0.003 0.023 0.5
Giardia lamblia Hexose transporter 0.003 0.023 0.346
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2276 0.59
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.023 0.0201
Brugia malayi hypothetical protein 0.003 0.023 0.0894
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0162
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0624 0.1563
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0625 0.0597
Schistosoma mansoni protein kinase 0.0065 0.0624 0.1563
Schistosoma mansoni protein kinase 0.0065 0.0624 0.1563
Trypanosoma cruzi glucose transporter, putative 0.003 0.023 0.303
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0625 0.0925
Echinococcus multilocularis solute carrier family 22 0.003 0.023 0.0527
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0634 0.868
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.01 0.2586
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0029 0.0262
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0299 0.3994
Brugia malayi hypothetical protein 0.003 0.023 0.0894
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.01 0.0071
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0149 0.06
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.01 0.3511
Plasmodium falciparum protein kinase 7 0.0599 0.6622 0.6612
Toxoplasma gondii exonuclease III APE 0.0018 0.01 0.013
Leishmania major glucose transporter, lmgt3 0.0066 0.0634 0.868
Mycobacterium ulcerans integral membrane transport protein 0.003 0.023 0.5239
Loa Loa (eye worm) hypothetical protein 0.0047 0.0427 0.1237
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0728 0.1081
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0343 0.3742 0.5643
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0147 0.2978
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0427 0.0399
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0397 0.1636
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2276 0.59
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.023 0.0625
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.023 0.0527
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0634 0.868
Schistosoma mansoni hypothetical protein 0.0351 0.3838 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0212 0.2276 0.59
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Leishmania major protein kinase, putative 0.0065 0.0624 0.855
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.023 0.0327
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0029 0.0024
Onchocerca volvulus 0.003 0.023 0.5
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0427 0.1044
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0091 0.0192
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0091 0.0162
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2276 0.59
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0091 0.0162
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0209 0.2867
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0609 0.9752
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0609 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0427 0.5862
Brugia malayi Sugar transporter family protein 0.003 0.023 0.0894
Echinococcus granulosus General substrate transporter 0.0182 0.1941 0.5021
Toxoplasma gondii sugar transporter ST2 0.003 0.023 0.0327
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.01 0.2084
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0625 0.0597
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0397 0.0965
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0347 0.5587
Onchocerca volvulus 0.003 0.023 0.5
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0029 0.0024
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Loa Loa (eye worm) hypothetical protein 0.0055 0.0513 0.1507
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0728 1
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0728 0.0701
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0634 0.274
Trichomonas vaginalis ran, putative 0.0021 0.0126 0.0497
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0091 0.0274
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0609 0.2583
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0609 0.1524
Onchocerca volvulus 0.003 0.023 0.5
Leishmania major glucose transporter, lmgt1 0.0066 0.0634 0.868
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Entamoeba histolytica Ran family GTPase 0.0021 0.0126 0.1626
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.01 0.1205
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0427 0.1044
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Schistosoma mansoni ap endonuclease 0.0018 0.01 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.2276 1
Loa Loa (eye worm) RNA binding protein 0.007 0.068 0.2027
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0728 1
Schistosoma mansoni protein kinase 0.0065 0.0624 0.1563
Onchocerca volvulus 0.003 0.023 0.5
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.0301
Schistosoma mansoni hypothetical protein 0.0351 0.3838 1
Leishmania major glucose transporter, lmgt2 0.0066 0.0634 0.868
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0029 0.0218
Loa Loa (eye worm) hypothetical protein 0.0038 0.0318 0.0898
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0427 0.6849
Schistosoma mansoni sugar transporter 0.003 0.023 0.0527
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0361 0.1536
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0126 0.0254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0397 0.0965
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0513 0.2154
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0427 0.5783
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.023 0.0527
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0634 0.8705
Onchocerca volvulus 0.003 0.023 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Schistosoma mansoni tar DNA-binding protein 0.007 0.068 0.171
Loa Loa (eye worm) hypothetical protein 0.0028 0.0209 0.0559
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0624 0.1563
Brugia malayi TAR-binding protein 0.007 0.068 0.2898
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0728 1
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0162
Schistosoma mansoni glucose transport protein 0.0212 0.2276 0.59
Brugia malayi Major Facilitator Superfamily protein 0.003 0.023 0.0894
Onchocerca volvulus Putative transporter 0.003 0.023 0.5
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0209 0.0295
Trichomonas vaginalis glucose transporter, putative 0.003 0.023 0.0956
Schistosoma mansoni tar DNA-binding protein 0.007 0.068 0.171
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.023 0.303
Brugia malayi major facilitator superfamily protein 0.003 0.023 0.0894
Brugia malayi major facilitator superfamily protein 0.003 0.023 0.0894
Echinococcus granulosus tar DNA binding protein 0.007 0.068 0.171
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Schistosoma mansoni sugar transporter 0.003 0.023 0.0527
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0579 0.1444
Schistosoma mansoni sugar transporter 0.003 0.023 0.0527
Trypanosoma brucei sugar transporter, putative 0.003 0.023 0.316
Brugia malayi Major Facilitator Superfamily protein 0.003 0.023 0.0894
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.0097
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0609 0.1524
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0192
Brugia malayi Importin beta-1 subunit 0.0028 0.0209 0.0799
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0609 0.1524
Brugia malayi hypothetical protein 0.003 0.023 0.0894
Onchocerca volvulus 0.003 0.023 0.5
Brugia malayi RNA, U transporter 1 0.0079 0.0787 0.3371
Trichomonas vaginalis conserved hypothetical protein 0.003 0.023 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0126 0.0097
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.023 0.6499
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0728 0.0701
Loa Loa (eye worm) hypothetical protein 0.0064 0.0609 0.1806
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.003 0.023 0.0956
Trypanosoma brucei glucose transporter, putative 0.0066 0.0634 0.8705
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0634 0.868
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0625 0.0597
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0427 0.0399
Onchocerca volvulus 0.003 0.023 0.5
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0427 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Loa Loa (eye worm) hypothetical protein 0.0065 0.0624 0.1852
Echinococcus granulosus solute carrier family 22 0.003 0.023 0.0527
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0397 0.1144
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0625 0.0925
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2276 0.59
Trypanosoma brucei glucose transporter, putative 0.0066 0.0634 0.8705
Trypanosoma cruzi sugar transporter, putative 0.003 0.023 0.303
Schistosoma mansoni tar DNA-binding protein 0.007 0.068 0.171
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0347 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.023 0.0956
Trypanosoma brucei glucose transporter 2A 0.0066 0.0634 0.8705
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0147 0.3243
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0126 0.0254
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0427 0.1769
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0624 0.2699
Schistosoma mansoni sugar transporter 0.003 0.023 0.0527
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.023 0.6499
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0014 0.0186
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Echinococcus granulosus GPCR family 2 0.0017 0.0091 0.0162
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0609 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0513 0.1507
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0126 0.1573
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.023 0.0527
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0624 0.1563
Onchocerca volvulus 0.003 0.023 0.5
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0149 0.06
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0513 0.2154
Plasmodium falciparum importin beta, putative 0.0028 0.0209 0.018
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0427 0.1044
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0624 0.2648
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0625 0.0597
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0029 0.04
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0624 0.1563
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0579 0.1444
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trypanosoma brucei glucose transporter, putative 0.0066 0.0634 0.8705
Loa Loa (eye worm) sugar transporter 0.003 0.023 0.0625
Brugia malayi Sugar transporter family protein 0.0212 0.2276 1
Entamoeba histolytica hypothetical protein 0.0047 0.0427 0.6679
Brugia malayi Sugar transporter family protein 0.003 0.023 0.0894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0397 0.0965
Trypanosoma brucei glucose transporter, putative 0.0066 0.0634 0.8705
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0029 0.0377
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0624 0.1563
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0126 0.173
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0634 0.274
Trypanosoma cruzi hexose transporter 0.0066 0.0634 0.868
Schistosoma mansoni hypothetical protein 0.0298 0.3242 0.8435
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0427 0.0625
Echinococcus multilocularis solute carrier family 22 0.003 0.023 0.0527
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0609 0.1524
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0634 0.868
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0427 0.5783
Echinococcus multilocularis solute carrier family 22 0.003 0.023 0.0527
Trypanosoma brucei glucose transporter, putative 0.0066 0.0634 0.8705
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0209 0.2867
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0728 1
Schistosoma mansoni hypothetical protein 0.0212 0.2276 0.59
Plasmodium falciparum mitogen-activated protein kinase 2 0.0343 0.3742 0.3724
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0188 0.0496
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0728 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.01 0.1369
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.01 0.5958
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0343 0.3742 0.3724
Toxoplasma gondii protein kinase, putative 0.0599 0.6622 1
Brugia malayi RNA recognition motif domain containing protein 0.007 0.068 0.2898
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.068 0.2027
Schistosoma mansoni ran 0.0021 0.0126 0.0254
Schistosoma mansoni tar DNA-binding protein 0.007 0.068 0.171
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Leishmania major GTP-binding protein, putative 0.0021 0.0126 0.1573
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.01 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0634 0.274
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0624 0.1852
Echinococcus granulosus snurportin 1 0.0298 0.3242 0.8435
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0427 0.6932
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0162
Echinococcus multilocularis General substrate transporter 0.0182 0.1941 0.5021
Onchocerca volvulus 0.003 0.023 0.5
Echinococcus granulosus solute carrier family 22 0.003 0.023 0.0527
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0126 0.017
Giardia lamblia Sugar-proton symporter 0.003 0.023 0.346
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0427 0.1826
Schistosoma mansoni ap endonuclease 0.0018 0.01 0.0185
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.023 0.0625
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Onchocerca volvulus 0.003 0.023 0.5
Loa Loa (eye worm) sugar transporter 0.0212 0.2276 0.6994
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.01 0.0185
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0029 0.0377
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0625 0.0597
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0624 0.1563
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.01 0.0381
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.1667
Trypanosoma brucei glucose transporter, putative 0.0066 0.0634 0.8705
Plasmodium vivax hexose transporter 0.0212 0.2276 0.2253
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0091 0.0162
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0625 0.0925
Entamoeba histolytica protein kinase, putative 0.0065 0.0624 1
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0029 0.0468
Entamoeba histolytica protein kinase, putative 0.0065 0.0624 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0209 0.018
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0624 0.1563
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0624 0.1852
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0634 0.8705
Trypanosoma brucei glucose transporter, putative 0.0066 0.0634 0.8705
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2276 0.59
Plasmodium vivax sugar transporter, putative 0.003 0.023 0.0201
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.023 0.5239
Toxoplasma gondii sugar transporter ST3 0.003 0.023 0.0327
Echinococcus granulosus geminin 0.0351 0.3838 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.068 0.171
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.01 0.0314
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.01 0.1205
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0625 0.0597
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0149 0.1902
Loa Loa (eye worm) TAR-binding protein 0.007 0.068 0.2027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0397 0.0965
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0625 0.0597
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.0431
Plasmodium falciparum hexose transporter 0.0212 0.2276 0.2253
Schistosoma mansoni importin beta-1 0.0028 0.0209 0.0471
Schistosoma mansoni glucose transporter 0.003 0.023 0.0527
Trichomonas vaginalis sugar transporter, putative 0.003 0.023 0.0956
Schistosoma mansoni glucose transport protein 0.0212 0.2276 0.59
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0029 0.04
Echinococcus granulosus solute carrier family 22 0.003 0.023 0.0527
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0029 0.0218
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0625
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0126 0.1573
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.023 0.0527
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0624 0.1563
Loa Loa (eye worm) hypothetical protein 0.0064 0.0609 0.1806

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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