Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1881 | 0.8786 | 1 |
Onchocerca volvulus | 0.2118 | 0.9997 | 1 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1881 | 0.8786 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.2119 | 1 | 1 |
Loa Loa (eye worm) | FAT-3 protein | 0.0417 | 0.1326 | 0.151 |
Brugia malayi | acyl-CoA desaturase | 0.1881 | 0.8786 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.1326 | 0.151 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0238 | 0.041 | 0.5 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0417 | 0.1326 | 0.151 |
Onchocerca volvulus | 0.2118 | 0.9997 | 1 | |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0238 | 0.0413 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1881 | 0.8789 | 0.8738 |
Brugia malayi | Fatty acid desaturase family protein | 0.0238 | 0.041 | 0.0466 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0238 | 0.041 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.2119 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0238 | 0.0413 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0238 | 0.041 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0238 | 0.041 | 0.0466 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2119 | 1 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0238 | 0.041 | 0.0466 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0238 | 0.041 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0238 | 0.041 | 0.5 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0238 | 0.041 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1881 | 0.8789 | 0.8738 |
Leishmania major | delta-6 fatty acid desaturase | 0.0238 | 0.0413 | 0.0003 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0238 | 0.041 | 0.0466 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1881 | 0.8786 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0116 | 0.0132 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0238 | 0.0413 | 0.0003 |
Leishmania major | delta-5 fatty acid desaturase | 0.0417 | 0.1326 | 0.0956 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0238 | 0.0413 | 0.0003 |
Schistosoma mansoni | fatty acid desaturase | 0.0418 | 0.133 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC90 (functional) | = 125 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 8739 after 24 hrs by broth micro dilution assay | ChEMBL. | 21752498 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.