Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0306 | 0.0003 | 0.0003 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2161 | 0.8585 | 0.8585 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.0788 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.0788 | 0.0918 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0306 | 0 | 0.5 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0306 | 0.0003 | 0.0003 |
Schistosoma mansoni | fatty acid desaturase | 0.0496 | 0.0878 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0306 | 0 | 0.5 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0495 | 0.0875 | 0.102 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2161 | 0.8582 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0306 | 0 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0306 | 0 | 0.5 |
Loa Loa (eye worm) | FAT-3 protein | 0.0495 | 0.0875 | 0.102 |
Brugia malayi | acyl-CoA desaturase | 0.2161 | 0.8582 | 1 |
Leishmania major | delta-5 fatty acid desaturase | 0.0495 | 0.0875 | 0.0875 |
Onchocerca volvulus | 0.0496 | 0.0878 | 0.0098 | |
Loa Loa (eye worm) | hypothetical protein | 0.0495 | 0.0875 | 0.102 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0306 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.2467 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2161 | 0.8582 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2161 | 0.8582 | 1 |
Onchocerca volvulus | 0.2467 | 0.9997 | 1 | |
Onchocerca volvulus | 0.2467 | 0.9997 | 1 | |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0306 | 0 | 0.5 |
Leishmania major | delta-6 fatty acid desaturase | 0.0306 | 0.0003 | 0.0003 |
Leishmania major | fatty-acid desaturase, putative | 0.2467 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0329 | 0.0109 | 0.0127 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0329 | 0.0109 | 0.0127 |
Mycobacterium ulcerans | hypothetical protein | 0.0306 | 0.0003 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2467 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0306 | 0.0003 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2161 | 0.8585 | 0.8585 |
Brugia malayi | hypothetical protein | 0.0476 | 0.0788 | 0.0918 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.