Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fatty acid desaturase | 0.0499 | 0.0837 | 0.5 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0307 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2293 | 0.8662 | 0.8662 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0307 | 0 | 0.5 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0307 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0498 | 0.0834 | 0.0963 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0307 | 0 | 0.5 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0498 | 0.0834 | 0.0963 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0307 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2292 | 0.866 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.0573 | 0.0662 |
Brugia malayi | hypothetical protein | 0.0438 | 0.0573 | 0.0662 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0307 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.2599 | 0.9997 | 1 | |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0307 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0307 | 0.0003 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0407 | 0.044 | 0.0508 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0407 | 0.044 | 0.0508 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0307 | 0.0003 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.2599 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2599 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.0573 | 0.0662 |
Brugia malayi | acyl-CoA desaturase | 0.2292 | 0.866 | 1 |
Leishmania major | delta-6 fatty acid desaturase | 0.0307 | 0.0003 | 0.0003 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2292 | 0.866 | 0.5 |
Loa Loa (eye worm) | FAT-3 protein | 0.0498 | 0.0834 | 0.0963 |
Onchocerca volvulus | 0.0499 | 0.0837 | 0.0279 | |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0307 | 0.0003 | 0.0003 |
Leishmania major | delta-5 fatty acid desaturase | 0.0498 | 0.0834 | 0.0834 |
Onchocerca volvulus | 0.2599 | 0.9997 | 1 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2293 | 0.8662 | 0.8662 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.2599 | 1 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2292 | 0.866 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.