Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine beta-hydroxylase | Starlite/ChEMBL | References |
Homo sapiens | dopamine beta-hydroxylase (dopamine beta-monooxygenase) | Starlite/ChEMBL | References |
Bos taurus | Dopamine beta-hydroxylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K00503 dopamine beta-monooxygenase [EC1.14.17.1], putative | Get druggable targets OG5_129281 | All targets in OG5_129281 |
Schistosoma mansoni | dopamine-beta-monooxygenase | Get druggable targets OG5_129281 | All targets in OG5_129281 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0227 | 0.1856 | 0.3372 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0505 | 0.5506 | 1 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0448 | 0.475 | 0.475 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.5506 | 1 |
Plasmodium falciparum | amino acid transporter, putative | 0.0086 | 0 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0086 | 0 | 0.5 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0221 | 0.1769 | 0.3212 |
Echinococcus granulosus | serotonin transporter | 0.0505 | 0.5506 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0448 | 0.475 | 0.8628 |
Plasmodium falciparum | transporter, putative | 0.0086 | 0 | 0.5 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0448 | 0.475 | 0.8628 |
Onchocerca volvulus | 0.0505 | 0.5506 | 1 | |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0086 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0505 | 0.5506 | 0.5506 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.5506 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0505 | 0.5506 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0505 | 0.5506 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0448 | 0.475 | 0.8628 |
Toxoplasma gondii | hypothetical protein | 0.0086 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0448 | 0.475 | 0.8628 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0505 | 0.5506 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0505 | 0.5506 | 0.5506 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0122 | 0.0473 | 0.0859 |
Brugia malayi | Serotonin receptor | 0.0474 | 0.509 | 0.9245 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0086 | 0 | 0.5 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0448 | 0.475 | 0.8628 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.5506 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0122 | 0.0473 | 0.0859 |
Plasmodium vivax | hypothetical protein, conserved | 0.0086 | 0 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0086 | 0 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0505 | 0.5506 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0086 | 0 | 0.5 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0448 | 0.475 | 0.475 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0448 | 0.475 | 0.8628 |
Loa Loa (eye worm) | serotonin transporter b | 0.0505 | 0.5506 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0086 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (binding) | = 4.77 | Inhibition of dopamine beta hydroxylase | ChEMBL. | 7783140 |
-Log IC50 (binding) | = 4.77 | Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally | ChEMBL. | 2296023 |
IC50 (binding) | = 4.77 | Inhibition of dopamine beta hydroxylase | ChEMBL. | 7783140 |
IC50 (binding) | = 4.77 | Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally | ChEMBL. | 2296023 |
IC50 (binding) | = 4.77 | Inhibition of dopamine beta-hydroxylase (DbetaH) enzyme | ChEMBL. | 9435905 |
IC50 (binding) | = 17 uM | Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (7-38). | ChEMBL. | 3820219 |
IC50 (binding) | = 17 uM | Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (7-38). | ChEMBL. | 3820219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.