TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 517.457 | Formula: C23H30Cl2N10
H donors: 4 H acceptors: 0 LogP: 2.03 Rotable bonds: 2
Rule of 5 violations (Lipinski): 2
SMILES: NC1=NC(N(C(=N1)N)c1ccc2c(c1)Cc1c2ccc(c1)N1C(=NC(=NC1(C)C)N)N)(C)C.Cl.Cl
InChi: 1S/C23H28N10.2ClH/c1-22(2)30-18(24)28-20(26)32(22)14-5-7-16-12(10-14)9-13-11-15(6-8-17(13)16)33-21(27)29-19(25)31-23(33,3)4;;/h5-8,10-11H,9H2,1-4H3,(H4,24,26,28,30)(H4,25,27,29,31);2*1H
InChiKey: ZRMXUIVPACLCJL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	insulin receptor	0.0375	1	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0016	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1862	0.1822
Schistosoma mansoni	hypothetical protein	0.0036	0.0586	0.054
Echinococcus granulosus	tyrosine kinase	0.0016	0.0049	0.0049
Schistosoma mansoni	tyrosine kinase	0.0375	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0192	0.4929	0.4904
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0025	0.029	0.0242
Loa Loa (eye worm)	TK protein kinase	0.0019	0.0126	0.0077
Schistosoma mansoni	tyrosine kinase	0.0021	0.0171	0.0123
Echinococcus granulosus	activated cdc42 kinase 1	0.0016	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0082	0.1862	0.1822
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0025	0.029	0.029
Echinococcus granulosus	tyrosine kinase	0.0021	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1862	0.1822
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0171	0.0123
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0051	0.1006	0.0962
Schistosoma mansoni	fibrocystin l	0.0036	0.0586	0.054
Onchocerca volvulus		0.0082	0.1862	0.3643
Onchocerca volvulus		0.0021	0.0171	0.0245
Echinococcus granulosus	cyclin dependent kinase 5	0.0051	0.1006	0.1006
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0025	0.029	0.0242
Loa Loa (eye worm)	TK/INSR protein kinase	0.0375	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0021	0.0171	0.0123
Brugia malayi	Probable exocyst complex component Sec5	0.0036	0.0586	0.054
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0025	0.029	0.029
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1862	0.1822
Schistosoma mansoni	tyrosine kinase	0.0025	0.029	0.0242
Schistosoma mansoni	tyrosine kinase	0.0229	0.5962	0.5942
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0016	0.0049	0.0049
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0036	0.0586	0.5609
Echinococcus granulosus	integrin linked protein kinase	0.0016	0.0049	0.0049
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0025	0.029	0.029
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0016	0.0049	0.0049
Loa Loa (eye worm)	plexin A	0.0231	0.6021	0.6001
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0171	0.0123
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0018	0.0079	0.0313
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0016	0.0049	0.0049
Echinococcus granulosus	tyrosine protein kinase shark	0.0021	0.0171	0.0171
Schistosoma mansoni	tyrosine kinase	0.0025	0.029	0.0242
Plasmodium falciparum	protein kinase, putative	0.0018	0.0079	0.0313
Echinococcus multilocularis	exocyst complex component 2	0.0036	0.0586	0.054
Echinococcus multilocularis	cyclin dependent kinase 1	0.0051	0.1006	0.0962
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0021	0.0171	0.0123
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.1006	0.0962
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0021	0.0171	0.0123
Schistosoma mansoni	tyrosine kinase	0.0229	0.5962	0.5942
Loa Loa (eye worm)	sema domain-containing protein	0.0082	0.1862	0.1822
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0586	0.054
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0016	0.0049	0.0049
Echinococcus granulosus	tyrosine protein kinase pr2	0.0016	0.0049	0.0049
Loa Loa (eye worm)	SRC-1	0.0025	0.029	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1862	0.1822
Entamoeba histolytica	tyrosin kinase, putative	0.0052	0.1044	1
Brugia malayi	map kinase activated protein kinase protein 2	0.0211	0.545	0.5428
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0025	0.029	0.0242
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0019	0.0126	0.0126
Echinococcus granulosus	semaphorin 1A	0.0082	0.1862	0.1862
Onchocerca volvulus	Tyrosine kinase homolog	0.018	0.4605	0.9155
Brugia malayi	IPT/TIG domain containing protein	0.0036	0.0586	0.054
Echinococcus granulosus	epidermal growth factor receptor	0.0246	0.642	0.642
Brugia malayi	DNA-binding protein LAG-1	0.0036	0.0586	0.054
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0586	0.5609
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0171	0.0123
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0375	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0016	0.0049	0.0049
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0017	0.0053	0.0039
Echinococcus granulosus	epidermal growth factor receptor	0.0326	0.866	0.866
Trypanosoma cruzi	cdc2-related kinase 3	0.0051	0.1006	1
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0586	0.5609
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0016	0.0049	0.0049
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0021	0.0171	0.0171
Echinococcus granulosus	protein tyrosine kinase	0.0016	0.0049	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0586	0.5609
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0069	0.002
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0171	0.0123
Echinococcus multilocularis	tyrosine kinase	0.0021	0.0171	0.0123
Echinococcus granulosus	c src tyrosine kinase	0.0025	0.029	0.029
Schistosoma mansoni	tyrosine kinase	0.0025	0.029	0.0242
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0211	0.545	0.545
Schistosoma mansoni	tyrosine kinase	0.0023	0.0225	0.0176
Brugia malayi	Plexin repeat family protein	0.0196	0.5026	0.5001
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0016	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0171	0.0123
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0171	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5026	0.5001
Plasmodium falciparum	protein kinase 5	0.0051	0.1006	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0192	0.4929	0.4904
Onchocerca volvulus		0.0196	0.5026	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0021	0.0171	0.0171
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0018	0.0079	0.003
Echinococcus granulosus	tyrosine protein kinase Blk	0.0021	0.0171	0.0171
Schistosoma mansoni	protein kinase	0.0018	0.0079	0.003
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0326	0.866	0.8653
Trypanosoma brucei	cdc2-related kinase 3	0.0051	0.1006	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0051	0.1006	0.0962
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0171	0.0123
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0021	0.0171	0.0123
Echinococcus multilocularis	transcription factor collier	0.0036	0.0586	0.054
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0171	0.0123
Echinococcus granulosus	cyclin dependent kinase	0.0051	0.1006	0.1006
Brugia malayi	SH2 domain containing protein	0.0021	0.0171	0.0123
Echinococcus granulosus	semaphorin 5B	0.0082	0.1862	0.1862
Brugia malayi	SH2 domain containing protein	0.0021	0.0171	0.0123
Schistosoma mansoni	tyrosine kinase	0.0229	0.5962	0.5942
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0171	0.0123
Echinococcus multilocularis		0.0094	0.22	0.2161
Echinococcus multilocularis	activin receptor type	0.0018	0.0079	0.003
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1862	0.1822
Echinococcus multilocularis	cyclin dependent kinase	0.0051	0.1006	0.0962
Echinococcus multilocularis	cyclin dependent kinase 5	0.0051	0.1006	0.0962
Schistosoma mansoni	plexin	0.0196	0.5026	0.5001
Entamoeba histolytica	hypothetical protein	0.0036	0.0586	0.5396
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0025	0.029	0.0242
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1006	1
Trypanosoma brucei	protein kinase, putative	0.0018	0.0079	0.0313
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0036	0.0586	0.5609
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0016	0.0049	0.0049
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0036	0.0586	0.5609
Entamoeba histolytica	protein kinase, putative	0.0017	0.0053	0.0039
Echinococcus granulosus	tyrosine protein kinase HCK	0.0016	0.0049	0.0049
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0171	0.0123
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0025	0.029	0.029
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0016	0.0049	0.0049
Entamoeba histolytica	hypothetical protein	0.0017	0.0053	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0586	0.5609
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.1006	0.0962
Trypanosoma cruzi	cdc2-related kinase 1	0.0051	0.1006	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0025	0.029	0.0242
Entamoeba histolytica	cell division protein kinase 2, putative	0.0051	0.1006	0.962
Trypanosoma brucei	cdc2-related kinase 1	0.0051	0.1006	1
Entamoeba histolytica	cell surface protease gp63, putative	0.0036	0.0586	0.5396
Echinococcus granulosus	tyrosine protein kinase csk	0.0016	0.0049	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0051	0.1006	0.0962
Loa Loa (eye worm)	TK/ROR protein kinase	0.0019	0.0126	0.0077
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0586	0.5609
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0051	0.1006	0.1006
Onchocerca volvulus		0.0161	0.407	0.808
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0018	0.0079	0.0079
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0021	0.0171	0.0171
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0025	0.029	0.0242
Echinococcus granulosus	plexin a4	0.0231	0.6021	0.6021
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0051	0.1006	1
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0051	0.1006	1
Schistosoma mansoni	plexin	0.0114	0.2755	0.2719
Schistosoma mansoni	serine/threonine protein kinase	0.0211	0.545	0.5428
Entamoeba histolytica	hypothetical protein	0.0036	0.0586	0.5396
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0025	0.029	0.029
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0586	0.5609
Echinococcus multilocularis	tyrosine protein kinase shark	0.0021	0.0171	0.0123
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0025	0.029	0.029
Schistosoma mansoni	tyrosine kinase	0.0375	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0025	0.029	0.0242
Brugia malayi	Sema domain containing protein	0.0082	0.1862	0.1822
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0246	0.642	0.642
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0025	0.029	0.0242
Schistosoma mansoni	tyrosine kinase	0.0025	0.029	0.0242
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0171	0.0123
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0018	0.0079	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0167	0.4225	0.4196
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0051	0.1006	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0025	0.029	0.0242
Trypanosoma cruzi	cdc2-related kinase 3	0.0051	0.1006	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0586	0.054
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0026	0.032	0.032
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0018	0.0079	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2755	0.2719
Onchocerca volvulus		0.0021	0.0171	0.0245
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0019	0.0126	0.0077
Brugia malayi	Sema domain containing protein	0.0082	0.1862	0.1822
Entamoeba histolytica	hypothetical protein	0.0017	0.0053	0.0039
Entamoeba histolytica	hypothetical protein	0.0036	0.0586	0.5396
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0586	0.5609
Brugia malayi	cell division control protein 2 homolog	0.0051	0.1006	0.0962
Echinococcus granulosus	transcription factor collier	0.0036	0.0586	0.0586
Schistosoma mansoni	hypothetical protein	0.0114	0.2755	0.2719
Echinococcus multilocularis	epidermal growth factor receptor	0.0246	0.642	0.6403
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0211	0.545	0.5428
Onchocerca volvulus		0.0021	0.0171	0.0245
Echinococcus granulosus	receptor type guanylyl cyclase	0.0016	0.0049	0.0049
Brugia malayi	protein-tyrosine kinase	0.0021	0.0171	0.0123
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0036	0.0586	0.5609
Echinococcus granulosus	protein kinase	0.0016	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0036	0.0586	0.054
Echinococcus granulosus	roundabout 2	0.0017	0.0069	0.0069
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0171	0.0123
Echinococcus granulosus	natriuretic peptide receptor 1	0.0016	0.0049	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0171	0.0123
Trypanosoma cruzi	cdc2-related kinase 1	0.0051	0.1006	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0375	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1006	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0069	0.002
Schistosoma mansoni	hypothetical protein	0.0082	0.1862	0.1822
Onchocerca volvulus		0.0021	0.0171	0.0245
Echinococcus granulosus	cyclin dependent kinase 1	0.0051	0.1006	0.1006
Schistosoma mansoni	hypothetical protein	0.0082	0.1862	0.1822
Echinococcus multilocularis	roundabout 2	0.0017	0.0069	0.002
Echinococcus multilocularis	hypothetical protein	0.0082	0.1862	0.1822
Giardia lamblia	Kinase, CMGC CDK	0.0051	0.1006	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0016	0.0049	0.0049
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0016	0.0049	0.0049
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0016	0.0049	0.0049
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0021	0.0171	0.0123
Entamoeba histolytica	protein kinase domain containing protein	0.0018	0.0079	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0586	0.054
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0016	0.0049	0.0049
Entamoeba histolytica	cell division protein kinase 2, putative	0.0051	0.1006	0.962
Echinococcus granulosus	activin receptor type	0.0018	0.0079	0.0079
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0016	0.0049	0.0049
Brugia malayi	plexin A	0.0231	0.6021	0.6001
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1006	1
Brugia malayi	hypothetical protein	0.0021	0.0171	0.0123
Echinococcus multilocularis	cyclin dependent kinase 1	0.0051	0.1006	0.0962
Onchocerca volvulus		0.0021	0.0171	0.0245
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0025	0.029	0.0242
Schistosoma mansoni	tyrosine kinase	0.0246	0.642	0.6403
Brugia malayi	Tyrosine-protein kinase abl-1	0.0025	0.029	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1862	0.1822
Plasmodium vivax	protein kinase Crk2	0.0051	0.1006	1
Brugia malayi	Protein kinase domain containing protein	0.0183	0.4683	0.4656
Schistosoma mansoni	tyrosine kinase	0.0021	0.0171	0.0123
Schistosoma mansoni	semaphorin 5-related	0.0082	0.1862	0.1822
Echinococcus multilocularis	plexin a4	0.0231	0.6021	0.6001
Schistosoma mansoni	protein kinase	0.0018	0.0079	0.003
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0171	0.0123
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0051	0.1006	0.0962
Echinococcus granulosus	tyrosine protein kinase	0.0016	0.0049	0.0049
Echinococcus granulosus	raf serine:threonine protein kinase	0.0016	0.0049	0.0049
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0211	0.545	0.5428
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0021	0.0171	0.0171
Echinococcus granulosus	tyrosine protein kinase csk	0.0016	0.0049	0.0049
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0021	0.0171	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0586	0.054
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0025	0.029	0.0242
Echinococcus granulosus	exocyst complex component 2	0.0036	0.0586	0.0586
Schistosoma mansoni	tyrosine kinase	0.0246	0.642	0.6403
Brugia malayi	Furin-like cysteine rich region family protein	0.0326	0.866	0.8653
Leishmania major	protein kinase, putative	0.0018	0.0079	0.0313
Echinococcus multilocularis	epidermal growth factor receptor	0.0326	0.866	0.8653
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0171	0.0123
Entamoeba histolytica	hypothetical protein	0.0036	0.0586	0.5396
Entamoeba histolytica	protein kinase domain containing protein	0.0052	0.1044	1
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0171	0.0123
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0171	0.0123
Giardia lamblia	Kinase, CMGC CDK	0.0051	0.1006	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0021	0.0171	0.1228
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0018	0.0079	0.0313
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0025	0.029	0.0242
Schistosoma mansoni	protein kinase	0.0018	0.0079	0.003
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0036	0.0586	0.5609
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0019	0.0126	0.0077
Echinococcus granulosus	tyrosine kinase	0.0021	0.0171	0.0171
Entamoeba histolytica	hypothetical protein	0.0017	0.0053	0.0039
Schistosoma mansoni	serine/threonine protein kinase	0.0021	0.0168	0.012
Loa Loa (eye worm)	hypothetical protein	0.005	0.0976	0.0932
Schistosoma mansoni	tyrosine kinase	0.0326	0.866	0.8653
Echinococcus granulosus	activated cdc42 kinase 1	0.0016	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0082	0.1862	0.1822
Echinococcus multilocularis	c src tyrosine kinase	0.0025	0.029	0.0242
Brugia malayi	SRC-1	0.0025	0.029	0.0242
Echinococcus granulosus	insulin receptor	0.0375	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0025	0.029	0.029
Onchocerca volvulus		0.0021	0.0171	0.0245
Echinococcus multilocularis	semaphorin 5B	0.0082	0.1862	0.1822
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0025	0.029	0.029
Loa Loa (eye worm)	sema domain-containing protein	0.0082	0.1862	0.1822
Echinococcus granulosus	tyrosine protein kinase csk	0.0016	0.0049	0.0049

Activities

Activity type	Activity value	Assay description	Source	Reference
Delta MST (functional)	= 2 day	Antitrypanosomal activity against Trypanosoma rhodesiense infections in mice, 106 mg/kg administered subcutaneously	ChEMBL.	4067999
Delta MST (functional)	= 3 day	Antitrypanosomal activity was evaluated against Trypanosoma rhodesiense infections in mice,at dose 26 mg/kg,administered subcutaneously;Cures	ChEMBL.	4067999
Delta MST (functional)	= 3 day	Antitrypanosomal activity was evaluated against Trypanosoma rhodesiense infections in mice,at dose 1.6mg/kg,administered subcutaneously	ChEMBL.	4067999
Delta MST (functional)	= 4 day	Antitrypanosomal activity against Trypanosoma rhodesiense infections in mice, 3.3 mg/kg administered subcutaneously	ChEMBL.	4067999
Delta MST (functional)	= 4.3 day	Antitrypanosomal activity against Trypanosoma rhodesiense infections in mice, 6.6 mg/kg administered subcutaneously	ChEMBL.	4067999
Delta MST (functional)	= 4.5 day	Antitrypanosomal activity against Trypanosoma rhodesiense infections in mice, 13 mg/kg administered subcutaneously	ChEMBL.	4067999
Delta MST (functional)	= 4.5 day	Anti-trypanosomal activity against Trypanosoma rhodesiense infections in mice, 26 mg/kg administered subcutaneously	ChEMBL.	4067999
Delta MST (functional)	= 26 day	Antitrypanosomal activity was evaluated against Trypanosoma rhodesiense infections in mice,at dose 212 mg/kg,administered subcutaneously	ChEMBL.	4067999
Toxic (functional)	= 3	Antitrypanosomal activity was evaluated against Trypanosoma rhodesiense infections in mice,at dose 106 mg/kg,administered subcutaneously;Toxic	ChEMBL.	4067999
Toxic (functional)	= 5	Antitrypanosomal activity against Trypanosoma rhodesiense infections in mice, 424 mg/kg administered subcutaneously	ChEMBL.	4067999

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL558203

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1051756