Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0271 | 0.0428 | 1 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.027 | 0.0425 | 0.5 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.027 | 0.0425 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2002 | 0.8707 | 0.8649 |
Leishmania major | delta-6 fatty acid desaturase | 0.0271 | 0.0428 | 0.0003 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0271 | 0.0428 | 0.0003 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0248 | 0.0318 | 0.0365 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2002 | 0.8704 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.027 | 0.0425 | 0.0127 |
Loa Loa (eye worm) | fatty acid desaturase | 0.027 | 0.0425 | 0.0488 |
Leishmania major | delta-5 fatty acid desaturase | 0.0452 | 0.1293 | 0.0907 |
Schistosoma mansoni | fatty acid desaturase | 0.0453 | 0.1296 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.2273 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2002 | 0.8704 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2002 | 0.8704 | 1 |
Onchocerca volvulus | 0.2272 | 0.9997 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 0.1293 | 0.1486 |
Brugia malayi | acyl-CoA desaturase | 0.2002 | 0.8704 | 1 |
Loa Loa (eye worm) | FAT-3 protein | 0.0452 | 0.1293 | 0.1486 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0452 | 0.1293 | 0.1163 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.027 | 0.0425 | 0.5 |
Onchocerca volvulus | 0.2272 | 0.9997 | 1 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2002 | 0.8707 | 0.8649 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.027 | 0.0425 | 0.5 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0271 | 0.0428 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.2273 | 1 | 1 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.027 | 0.0425 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.027 | 0.0425 | 0.0127 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2273 | 1 | 1 |
Loa Loa (eye worm) | fatty acid desaturase | 0.027 | 0.0425 | 0.0488 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.027 | 0.0425 | 0.5 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0271 | 0.0428 | 0.0003 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19725581 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.