Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | FAT-3 protein | 0.0417 | 0.1417 | 0.1628 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.1417 | 0.1628 |
Brugia malayi | acyl-CoA desaturase | 0.1756 | 0.8703 | 1 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0238 | 0.0438 | 0.5 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0417 | 0.1417 | 0.1628 |
Onchocerca volvulus | 0.1993 | 0.9997 | 1 | |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1756 | 0.8703 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1756 | 0.8703 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.1994 | 1 | 1 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0238 | 0.0438 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1994 | 1 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0238 | 0.0438 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0238 | 0.0438 | 0.0503 |
Mycobacterium ulcerans | hypothetical protein | 0.0238 | 0.0441 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1994 | 1 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0238 | 0.0438 | 0.0503 |
Onchocerca volvulus | 0.1993 | 0.9997 | 1 | |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0238 | 0.0441 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0238 | 0.0438 | 0.0503 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1756 | 0.8707 | 0.8648 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0238 | 0.0438 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1756 | 0.8707 | 0.8648 |
Leishmania major | delta-6 fatty acid desaturase | 0.0238 | 0.0441 | 0.0004 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0238 | 0.0438 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0238 | 0.0438 | 0.5 |
Schistosoma mansoni | fatty acid desaturase | 0.0418 | 0.142 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0238 | 0.0438 | 0.0503 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1756 | 0.8703 | 0.5 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0238 | 0.0441 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0123 | 0.0142 |
Leishmania major | delta-5 fatty acid desaturase | 0.0417 | 0.1417 | 0.1024 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0238 | 0.0441 | 0.0004 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.