Detailed information for compound 1052957

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.332 | Formula: C17H14N6O2
  • H donors: 2 H acceptors: 5 LogP: 1.78 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc2c(nc1NC(=O)C)nn(c2NC(=O)C)c1ccccc1
  • InChi: 1S/C17H14N6O2/c1-10(24)19-15-12(9-18)8-14-16(21-15)22-23(17(14)20-11(2)25)13-6-4-3-5-7-13/h3-8H,1-2H3,(H,20,25)(H,19,21,22,24)
  • InChiKey: ASHKDGWGEMYKIM-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0797 0.0832
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0382 0.1008
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0108 0.2371 0.2371
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.3933 0.3933
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0078 0.1266 0.1322
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0078 0.1266 0.1266
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0455 0.0455
Toxoplasma gondii hypothetical protein 0.0052 0.0339 0.4253
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0377 0.0393
Echinococcus granulosus dual specificity 0.0108 0.2371 0.2475
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0372 1
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0372 0.0372
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0377 0.0993
Loa Loa (eye worm) hypothetical protein 0.0052 0.0332 0.0347
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0078 0.1266 0.1322
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0372 0.0388
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0101 0.0101
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.9577 1
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0372 0.0388
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0321 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0101 0.0101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0377 0.0393
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0053 0.0382 0.0399
Plasmodium falciparum protein kinase 5 0.0053 0.0372 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0377 0.0393
Loa Loa (eye worm) hypothetical protein 0.0148 0.3793 0.396
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.0372 0.0372
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0797 0.1752
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0101 0.0101
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0078 0.1266 0.1322
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0372 0.4666
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0101 0.0101
Onchocerca volvulus 0.0042 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0108 0.2371 0.625
Brugia malayi cell division control protein 2 homolog 0.0053 0.0372 0.098
Echinococcus multilocularis dual specificity 0.0108 0.2371 0.2475
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0372 0.0388
Entamoeba histolytica protein kinase domain containing protein 0.0108 0.2371 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0377 0.0393
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0372 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0377 0.0393
Loa Loa (eye worm) hypothetical protein 0.0148 0.3793 0.396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0377 0.0393
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0372 0.0388
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0372 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.027 0.8185 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.1266 0.1266
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0382 0.1008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0797 0.1752
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0372 0.0388
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.3933 0.3933
Entamoeba histolytica protein kinase, putative 0.0108 0.2371 1
Entamoeba histolytica protein kinase, putative 0.0108 0.2371 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 1 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0108 0.2371 0.2475
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0093 0.0097
Brugia malayi Protein kinase domain containing protein 0.0053 0.0372 0.098
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0797 0.0832
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0797 0.1752
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.0372 0.0372
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.4548 0.5557
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0078 0.1266 0.4473
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0797 0.0797
Brugia malayi hypothetical protein 0.0148 0.3793 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.2371 0.2371
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0372 0.0388
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.9577 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0797 0.0832
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0372 0.0388
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0372 0.0372
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0372 0.0388
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0382 0.0399
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0372 0.0388
Loa Loa (eye worm) hypothetical protein 0.0107 0.2331 0.2434
Mycobacterium leprae conserved hypothetical protein 0.0042 0 0.5
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0372 0.0372
Mycobacterium ulcerans hypothetical protein 0.0169 0.4548 1
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0372 0.0388
Loa Loa (eye worm) hypothetical protein 0.0107 0.2331 0.2434
Mycobacterium leprae Probable lipase LipE 0.0042 0 0.5
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0372 0.0388
Entamoeba histolytica hypothetical protein 0.0108 0.2371 1
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0372 0.0372
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0093 0.0097
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0797 1
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0372 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.2371 0.2475
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0797 0.0974
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.1266 0.1266
Loa Loa (eye worm) hypothetical protein 0.0309 0.9577 1
Onchocerca volvulus 0.0042 0 0.5
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0372 0.5
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.2371 0.2371
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0078 0.1266 0.1322
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.9577 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0372 0.0388
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.1266 0.1266
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.3933 0.3933
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 1 1
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0372 0.0372
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0108 0.2371 0.2371
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0797 0.0832
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0078 0.1266 0.3338
Plasmodium vivax protein kinase Crk2 0.0053 0.0372 1
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0372 0.0388
Onchocerca volvulus 0.0042 0 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0377 0.0393
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0377 0.0393

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibition of human recombinant GST-fusion DYRK1A expressed in Escherichia coli ChEMBL. 19615897
IC50 (binding) > 10 uM Inhibition of human recombinant CDK5/P25 by scintillation counting ChEMBL. 19615897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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