Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Diaminopimelate decarboxylase LysA (DAP decarboxylase) | 0.0044 | 0.1225 | 0.5 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0146 | 1 | 1 |
Trichomonas vaginalis | pyridoxal-dependent decarboxylase, putative | 0.0044 | 0.1225 | 0.5 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0097 | 0.574 | 0.4852 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1723 | 0.2897 |
Echinococcus multilocularis | lamin b receptor | 0.0097 | 0.574 | 1 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0044 | 0.1225 | 0.5 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0146 | 1 | 1 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.007 | 0.3463 | 0.5 |
Giardia lamblia | Ornithine decarboxylase | 0.0044 | 0.1225 | 0.5 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0044 | 0.1225 | 0.5 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0146 | 1 | 1 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0044 | 0.1225 | 0.5 |
Leishmania major | C-14 sterol reductase, putative | 0.0097 | 0.574 | 0.5145 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.5948 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.474 | 0.7969 |
Brugia malayi | Cation transporter family protein | 0.0099 | 0.5948 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.5948 | 1 |
Onchocerca volvulus | 0.0099 | 0.5948 | 0.5948 | |
Toxoplasma gondii | diaminopimelate decarboxylase | 0.0044 | 0.1225 | 0.5 |
Trypanosoma brucei | C-14 sterol reductase, putative | 0.0097 | 0.574 | 0.5145 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0146 | 1 | 1 |
Leishmania major | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0146 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0099 | 0.5948 | 1 |
Onchocerca volvulus | 0.0146 | 1 | 1 | |
Onchocerca volvulus | 0.0099 | 0.5948 | 0.5948 | |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0044 | 0.1225 | 0.5 |
Loa Loa (eye worm) | pyridoxal-dependent decarboxylase | 0.0044 | 0.1225 | 0.2059 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.007 | 0.3463 | 0.5 |
Trypanosoma brucei | Emopamil binding protein, putative | 0.0146 | 1 | 1 |
Echinococcus granulosus | lamin b receptor | 0.0097 | 0.574 | 1 |
Mycobacterium ulcerans | diaminopimelate decarboxylase LysA | 0.0044 | 0.1225 | 0.5 |
Onchocerca volvulus | 0.0099 | 0.5948 | 0.5948 | |
Leishmania major | sterol C-24 reductase, putative | 0.005 | 0.1723 | 0.0568 |
Brugia malayi | Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein | 0.0044 | 0.1225 | 0.2059 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0099 | 0.5948 | 1 |
Schistosoma mansoni | Lamin B receptor (ERG24) | 0.0097 | 0.574 | 0.9649 |
Entamoeba histolytica | ornithine decarboxylase, putative | 0.0044 | 0.1225 | 0.5 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0097 | 0.574 | 0.4852 |
Onchocerca volvulus | 0.0044 | 0.1225 | 0.1225 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.