Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0325 | 0.1228 | 0.1228 |
Loa Loa (eye worm) | norepinephrine transporter | 0.1912 | 0.919 | 0.9106 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0325 | 0.1228 | 0.032 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0325 | 0.1228 | 0.1228 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0325 | 0.1228 | 0.1228 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.2074 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 0.1228 | 0.032 |
Echinococcus granulosus | adam 17 protease | 0.014 | 0.0301 | 0.0301 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0325 | 0.1228 | 0.1015 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.2074 | 1 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0325 | 0.1228 | 0.1015 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.1912 | 0.919 | 0.917 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0325 | 0.1228 | 0.1015 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.1912 | 0.919 | 0.9077 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.2074 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1912 | 0.919 | 0.9106 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.2074 | 1 | 0.5 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.2074 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0325 | 0.1228 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.1912 | 0.919 | 0.9106 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0325 | 0.1228 | 0.1015 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0325 | 0.1228 | 0.1015 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.2074 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.1912 | 0.919 | 0.5 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.2074 | 1 | 1 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0325 | 0.1228 | 0.1015 |
Loa Loa (eye worm) | serotonin transporter b | 0.1912 | 0.919 | 0.9106 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0325 | 0.1228 | 0.1228 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 0.1228 | 0.032 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.2074 | 1 | 0.5 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.2074 | 1 | 0.5 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.2074 | 1 | 1 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.2074 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 0.1228 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.1912 | 0.919 | 0.9106 |
Echinococcus multilocularis | 0.2074 | 1 | 1 | |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0325 | 0.1228 | 0.1228 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0325 | 0.1228 | 0.1228 |
Echinococcus granulosus | serotonin transporter | 0.1912 | 0.919 | 0.919 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0325 | 0.1228 | 0.1228 |
Onchocerca volvulus | 0.1912 | 0.919 | 1 | |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.2074 | 1 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.0127 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 0.1228 | 0.032 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0325 | 0.1228 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 0.1228 | 0.032 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0325 | 0.1228 | 0.1228 |
Mycobacterium ulcerans | hypothetical protein | 0.0905 | 0.4141 | 0.5 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.2074 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0325 | 0.1228 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 0.1228 | 0.032 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.2074 | 1 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0325 | 0.1228 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 0.1228 | 0.032 |
Echinococcus multilocularis | serotonin transporter | 0.1912 | 0.919 | 0.919 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.2074 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0905 | 0.4141 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.1912 | 0.919 | 0.9106 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.1912 | 0.919 | 0.917 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0325 | 0.1228 | 0.1228 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0325 | 0.1228 | 0.1015 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.2074 | 1 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0325 | 0.1228 | 0.1015 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0325 | 0.1228 | 0.1228 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0325 | 0.1228 | 0.1228 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0325 | 0.1228 | 0.032 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.59 ug/ml | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro | ChEMBL. | No reference |
IC50 | > 50 ug/ml | DNDI: Cytotoxicity against L929 mouse fibroblasts, CYTO-SP, 24 hour | ChEMBL. | No reference |
Inhibition (functional) | = 99 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | |||
Trypanosoma brucei | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.