Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | wnt related | 0.0152 | 0.1776 | 0.2712 |
Echinococcus granulosus | protein Wnt 2 | 0.0152 | 0.1776 | 0.2712 |
Echinococcus multilocularis | wnt family member wnt11 2 | 0.0152 | 0.1776 | 0.2712 |
Schistosoma mansoni | wnt-5 | 0.0152 | 0.1776 | 0.2712 |
Echinococcus multilocularis | WNT | 0.0152 | 0.1776 | 0.2712 |
Brugia malayi | wnt family protein | 0.0152 | 0.1776 | 0.2712 |
Echinococcus multilocularis | protein Wnt 2 | 0.0152 | 0.1776 | 0.2712 |
Echinococcus multilocularis | WNT | 0.0152 | 0.1776 | 0.2712 |
Brugia malayi | Wnt-4 protein precursor | 0.0152 | 0.1776 | 0.2712 |
Brugia malayi | Wnt-2 protein precursor | 0.0152 | 0.1776 | 0.2712 |
Brugia malayi | wnt family protein | 0.0152 | 0.1776 | 0.2712 |
Echinococcus multilocularis | netrin 1 | 0.0291 | 0.6551 | 1 |
Echinococcus multilocularis | wingless type MMTV integration site family | 0.0152 | 0.1776 | 0.2712 |
Schistosoma mansoni | netrin | 0.0291 | 0.6551 | 1 |
Brugia malayi | wnt family protein | 0.0152 | 0.1776 | 0.2712 |
Echinococcus granulosus | Protein Wnt-11b | 0.0152 | 0.1776 | 0.2712 |
Loa Loa (eye worm) | CWN-2 protein | 0.0152 | 0.1776 | 0.2712 |
Echinococcus multilocularis | protein Wnt 1 | 0.0152 | 0.1776 | 0.2712 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1776 | 0.2712 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1776 | 0.2712 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1776 | 0.2712 |
Echinococcus granulosus | netrin 1 | 0.0291 | 0.6551 | 1 |
Schistosoma mansoni | wnt related | 0.0152 | 0.1776 | 0.2712 |
Schistosoma mansoni | wnt related | 0.0152 | 0.1776 | 0.2712 |
Schistosoma mansoni | wnt related | 0.0152 | 0.1776 | 0.2712 |
Brugia malayi | Unc-6 protein precursor | 0.0291 | 0.6551 | 1 |
Schistosoma mansoni | netrin | 0.0291 | 0.6551 | 1 |
Loa Loa (eye worm) | wnt-4 protein | 0.0152 | 0.1776 | 0.2712 |
Echinococcus granulosus | Protein Wnt-04 | 0.0152 | 0.1776 | 0.2712 |
Brugia malayi | wnt family protein | 0.0152 | 0.1776 | 0.2712 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 0.6551 | 1 |
Echinococcus granulosus | protein Wnt 1 | 0.0152 | 0.1776 | 0.2712 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1776 | 0.2712 |
Echinococcus granulosus | Protein Wnt-111 | 0.0152 | 0.1776 | 0.2712 |
Loa Loa (eye worm) | Wnt2 protein | 0.0152 | 0.1776 | 0.2712 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1776 | 0.2712 |
Echinococcus granulosus | Protein Wnt-5 | 0.0152 | 0.1776 | 0.2712 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10000 nM | Binding affinity towards benzodiazepine receptor by the displacement of [3H]-flunitrazepam from rat brain preparations. | ChEMBL. | 1648620 |
IC50 (binding) | = 10000 nM | Binding affinity towards benzodiazepine receptor by the displacement of [3H]-flunitrazepam from rat brain preparations. | ChEMBL. | 1648620 |
MED (functional) | = 10 mg kg-1 | Minimum effective dose on oral administration | ChEMBL. | 1648620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.