Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Echinococcus granulosus | bile acid beta glucosidase | 0.2597 | 0.8043 | 0.8714 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Leishmania major | glycosyl hydrolase-like protein | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2228 | 0.6888 | 0.6844 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2228 | 0.6888 | 0.6844 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 0.0847 | 0.0918 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Giardia lamblia | Ceramide glucosyltransferase | 0.1349 | 0.4136 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0449 | 0.0449 |
Trichomonas vaginalis | glycoside hydrolases, putative | 0.013 | 0.032 | 0.0184 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1753 | 0.54 | 0.54 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0171 | 0.0449 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0427 | 0.0463 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0299 | 0.0847 | 0.0847 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0064 | 0.0064 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0171 | 0.0449 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0171 | 0.0449 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.2976 | 0.923 | 0.923 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0064 | 0.0064 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0171 | 0.0449 | 0.0487 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Schistosoma mansoni | alpha glucosidase | 0.0171 | 0.0449 | 0.0487 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1786 | 0.5504 | 0.5504 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0176 | 0.0191 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0077 | 0.0154 | 0.0167 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0427 | 0.0463 |
Echinococcus multilocularis | geminin | 0.0164 | 0.0427 | 0.0463 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0064 | 0.0064 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Echinococcus multilocularis | snurportin 1 | 0.0299 | 0.0847 | 0.0918 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0016 | 0.0016 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1786 | 0.5504 | 0.5504 |
Trypanosoma brucei | glucosidase, putative | 0.0171 | 0.0449 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0176 | 0.0191 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0077 | 0.0154 | 0.0154 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Echinococcus granulosus | snurportin 1 | 0.0299 | 0.0847 | 0.0918 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.2114 | 0.6531 | 0.6926 |
Schistosoma mansoni | alpha-glucosidase | 0.1786 | 0.5504 | 0.5963 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.0161 | 0.0161 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Trichomonas vaginalis | beta-glucosidase, putative | 0.013 | 0.032 | 0.0184 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0171 | 0.0449 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.3222 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.2597 | 0.8043 | 0.8714 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0 | 0.5 |
Brugia malayi | Ceramide glucosyltransferase | 0.2976 | 0.923 | 0.923 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2597 | 0.8043 | 0.8714 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0171 | 0.0449 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0122 | 0.0122 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0016 | 0.0017 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0171 | 0.0449 | 0.0487 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2597 | 0.8043 | 0.8714 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0016 | 0.0016 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0171 | 0.0449 | 0.0315 |
Schistosoma mansoni | alpha-glucosidase | 0.1786 | 0.5504 | 0.5963 |
Echinococcus granulosus | geminin | 0.0164 | 0.0427 | 0.0463 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0171 | 0.0449 | 0.0315 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Onchocerca volvulus | 0.12 | 0.367 | 0.3667 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0077 | 0.0154 | 0.0167 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.2597 | 0.8043 | 0.8714 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0077 | 0.0154 | 0.0154 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.2597 | 0.8043 | 0.8714 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.2976 | 0.923 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 100 mg kg-1 | Antiandrogenic activity as the dose required to inhibit testosterone propionate-induced rat ventral prostrate weight gain in castrated immature rat by 50%. | ChEMBL. | 2374140 |
RBA (binding) | < 0.01 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 1 hour. | ChEMBL. | 2374140 |
RBA (binding) | < 0.01 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 18 hours. | ChEMBL. | 2374140 |
RBA (binding) | < 0.01 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 1 hour. | ChEMBL. | 2374140 |
RBA (binding) | < 0.01 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 18 hours. | ChEMBL. | 2374140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.