Detailed view for TVAG_057370

Basic information

TDR Targets ID: 858845
Trichomonas vaginalis, beta-glucosidase, putative
Source Database / ID: 

pI: 6.5032 | Length (AA): 454 | MW (Da): 53270 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00232   Glycosyl hydrolase family 1

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126690)

Species Accession Gene Product
Arabidopsis thaliana AT5G42260   beta glucosidase 12
Arabidopsis thaliana AT1G26560   beta glucosidase 40
Arabidopsis thaliana AT2G25630   beta glucosidase 14
Arabidopsis thaliana AT5G44640   beta glucosidase 13
Arabidopsis thaliana AT2G44450   beta glucosidase 15
Arabidopsis thaliana AT3G18070   beta glucosidase 43
Arabidopsis thaliana AT5G36890   beta glucosidase 42
Arabidopsis thaliana AT3G60130   beta glucosidase 16
Arabidopsis thaliana AT3G18080   beta-glucosidase 44
Caenorhabditis elegans CELE_C50F7.10   Protein KLO-1
Caenorhabditis elegans CELE_E02H9.5   Protein KLO-2
Drosophila melanogaster Dmel_CG9701   CG9701 gene product from transcript CG9701-RA
Escherichia coli b3721   cryptic phospho-beta-glucosidase B
Escherichia coli b2901   6-phospho-beta-glucosidase A
Escherichia coli b2716   cryptic 6-phospho-beta-glucosidase
Homo sapiens ENSG00000133116   klotho
Homo sapiens ENSG00000115850   lactase
Homo sapiens ENSG00000188501   lactase-like
Homo sapiens ENSG00000134962   klotho beta
Mus musculus ENSMUSG00000029195   klotho beta
Mus musculus ENSMUSG00000058488   klotho
Mus musculus ENSMUSG00000032401   lactase-like
Mus musculus ENSMUSG00000026354   lactase
Oryza sativa 4336146   Os04g0474900
Oryza sativa 4348315   Os10g0323500
Oryza sativa 4324050   Os01g0508000
Oryza sativa 4333841   Os03g0703000
Oryza sativa 4333842   Os03g0703100
Oryza sativa 4336145   Os04g0474800
Oryza sativa 4325106   Os01g0897600
Oryza sativa 4332041   Os03g0212800
Schmidtea mediterranea mk4.044980.00  
Trichomonas vaginalis TVAG_360830   glycoside hydrolases, putative
Trichomonas vaginalis TVAG_057370   beta-glucosidase, putative

Essentiality

TVAG_057370 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2716 Escherichia coli non-essential goodall
b2901 Escherichia coli non-essential goodall
b3721 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Prunus avium Beta-glucosidase Compounds References
Rattus norvegicus Lactase-glycosylceramidase Compounds References
Homo sapiens lactase Compounds References
Caldicellulosiruptor saccharolyticus Beta-glucosidase A Compounds References
Homo sapiens Beta-glucosidase cytosolic Compounds References
Agrobacterium sp. ATCC 21400 Beta-glucosidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0403 0.3607 0.3607
0.0132 0.408 1
0.0271 0.8496 0.5
0.1168 0.4253 1
0.1066 0.44 1
0.1066 0.44 1
0.1036 0.2637 1
0.1267 0.2578 0.8883
0.1063 0.3219 0.4019
0.113 0.4261 1
0.11 0.513 1
0.0136 1 0.5
0.0132 0.408 1
0.1036 0.2637 1
0.0934 0.3841 1
0.0542 0.8262 1
0.0395 0.2981 0.7692
0.11 0.513 1
0.0159 0.4433 1
0.0632 0.6401 1
0.1066 0.44 1
0.1126 0.4341 1
0.0127 0.3676 0.3615
0.0427 0.657 1
0.0136 1 0.5
0.1157 0.2728 1
0.0132 0.408 1
0.0632 0.6401 1
0.1107 0.5939 1
0.0159 0.4433 1
0.043 0.4534 1
0.0268 0.4059 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_057370 (Trichomonas vaginalis), beta-glucosidase, putative
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