Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Brugia malayi | Ceramide glucosyltransferase | 0.2976 | 0.923 | 0.923 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2597 | 0.8043 | 0.8714 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.2597 | 0.8043 | 0.8714 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.3222 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0171 | 0.0449 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Trichomonas vaginalis | beta-glucosidase, putative | 0.013 | 0.032 | 0.0184 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.2114 | 0.6531 | 0.6926 |
Schistosoma mansoni | alpha-glucosidase | 0.1786 | 0.5504 | 0.5963 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.0161 | 0.0161 |
Echinococcus granulosus | snurportin 1 | 0.0299 | 0.0847 | 0.0918 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0077 | 0.0154 | 0.0154 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0176 | 0.0191 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0016 | 0.0016 |
Trypanosoma brucei | glucosidase, putative | 0.0171 | 0.0449 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1786 | 0.5504 | 0.5504 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.2976 | 0.923 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.2597 | 0.8043 | 0.8714 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0077 | 0.0154 | 0.0154 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0077 | 0.0154 | 0.0167 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.2597 | 0.8043 | 0.8714 |
Onchocerca volvulus | 0.12 | 0.367 | 0.3667 | |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0171 | 0.0449 | 0.0315 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Schistosoma mansoni | alpha-glucosidase | 0.1786 | 0.5504 | 0.5963 |
Echinococcus granulosus | geminin | 0.0164 | 0.0427 | 0.0463 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0171 | 0.0449 | 0.0315 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2597 | 0.8043 | 0.8714 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0171 | 0.0449 | 0.0487 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0016 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0016 | 0.0017 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0122 | 0.0122 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0171 | 0.0449 | 0.0315 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0171 | 0.0449 | 0.5 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0171 | 0.0449 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0299 | 0.0847 | 0.0847 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0064 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0427 | 0.0463 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0171 | 0.0449 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1753 | 0.54 | 0.54 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.1349 | 0.4136 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0449 | 0.0449 |
Trichomonas vaginalis | glycoside hydrolases, putative | 0.013 | 0.032 | 0.0184 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2228 | 0.6888 | 0.6844 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2228 | 0.6888 | 0.6844 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 0.0847 | 0.0918 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Leishmania major | glycosyl hydrolase-like protein | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Echinococcus granulosus | bile acid beta glucosidase | 0.2597 | 0.8043 | 0.8714 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Echinococcus multilocularis | snurportin 1 | 0.0299 | 0.0847 | 0.0918 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0064 | 0.0064 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Echinococcus multilocularis | geminin | 0.0164 | 0.0427 | 0.0463 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0427 | 0.0463 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0176 | 0.0191 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0077 | 0.0154 | 0.0167 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1786 | 0.5504 | 0.5504 |
Schistosoma mansoni | alpha glucosidase | 0.0171 | 0.0449 | 0.0487 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0171 | 0.0449 | 0.0487 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.2976 | 0.923 | 0.923 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0064 | 0.0064 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0064 | 0.0064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 100 mg kg-1 | Antiandrogenic activity as the dose required to inhibit testosterone propionate-induced rat ventral prostrate weight gain in castrated immature rat by 50%. | ChEMBL. | 2374140 |
Increase (functional) | = 50 % | Androgenic activity as percent increase in rat ventral prostrate (castrated immature rat) weight caused by 100 mg/kg per day x 10 oral dose | ChEMBL. | 2374140 |
Increase (functional) | = 50 % | Androgenic activity as percent increase in rat ventral prostrate (castrated immature rat) weight caused by 100 mg/kg per day x 10 oral dose | ChEMBL. | 2374140 |
RBA (binding) | = 0.1 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 18 hours. | ChEMBL. | 2374140 |
RBA (binding) | = 2.7 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 1 hour. | ChEMBL. | 2374140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.