Detailed information for compound 1062434

Basic information

Technical information
  • TDR Targets ID: 1062434
  • Name: 3,6-diamino-1-methylpyrazolo[4,5-e]pyridine-5 -carbonitrile
  • MW: 188.189 | Formula: C8H8N6
  • H donors: 2 H acceptors: 3 LogP: 0.41 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc2c(N)nn(c2nc1N)C
  • InChi: 1S/C8H8N6/c1-14-8-5(7(11)13-14)2-4(3-9)6(10)12-8/h2H,1H3,(H2,10,12)(H2,11,13)
  • InChiKey: UADYXCCWXCCSER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,6-diamino-1-methyl-pyrazolo[4,5-e]pyridine-5-carbonitrile
  • 3,6-diamino-1-methyl-5-pyrazolo[4,5-e]pyridinecarbonitrile
  • 1901-69-5
  • NSC165523

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis set domain proteins, putative 0.025 0.7987 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0492 0.0042
Loa Loa (eye worm) hypothetical protein 0.0107 0.3085 0.3085
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0094 0.262 0.2361
Giardia lamblia Kinase, CMGC CDK 0.0053 0.1215 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1067 0.1536
Trypanosoma brucei trypanothione reductase 0.0041 0.0818 0.2618
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.1215 0.0799
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.3123 0.2767
Echinococcus multilocularis lysosomal alpha glucosidase 0.0182 0.5663 0.5438
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.1215 0.0988
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0094 0.262 0.2361
Toxoplasma gondii aldehyde dehydrogenase 0.0264 0.8451 1
Entamoeba histolytica protein kinase, putative 0.0108 0.3123 1
Leishmania major hypothetical protein, conserved 0.003 0.0422 0.05
Schistosoma mansoni alpha glucosidase 0.004 0.0798 0.0322
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0818 0.4984
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1067 0.0644
Brugia malayi Protein kinase domain containing protein 0.0053 0.1215 0.175
Giardia lamblia Kinase, CMGC CDK 0.0053 0.1215 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0264 0.8451 1
Schistosoma mansoni hypothetical protein 0.0039 0.0757 0.0279
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.1215 0.1937
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0104 0.2978 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0264 0.8451 0.8371
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0757 0.0319
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1067 0.0605
Brugia malayi Protein kinase domain containing protein 0.0108 0.3123 0.4496
Brugia malayi cell division control protein 2 homolog 0.0053 0.1215 0.175
Mycobacterium tuberculosis Probable dehydrogenase 0.0094 0.262 0.2361
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0818 0.0818
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0818 0.2618
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0108 0.3123 0.3695
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.1215 0.3892
Echinococcus granulosus dual specificity 0.0108 0.3123 0.2797
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.1215 0.3892
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1215 0.058
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.1215 0.0761
Onchocerca volvulus 0.025 0.7987 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0836 0.0362
Plasmodium vivax protein kinase Crk2 0.0053 0.1215 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.3123 1
Plasmodium vivax glutathione reductase, putative 0.0041 0.0818 0.4984
Brugia malayi Cytochrome P450 family protein 0.0028 0.0384 0.0552
Entamoeba histolytica protein kinase domain containing protein 0.0108 0.3123 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1067 0.0605
Entamoeba histolytica protein kinase, putative 0.0108 0.3123 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1215 0.0761
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0422 0.1353
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0108 0.3123 1
Loa Loa (eye worm) hypothetical protein 0.0309 1 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0798 0.0468
Echinococcus multilocularis dual specificity 0.0108 0.3123 0.2767
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1067 0.0644
Toxoplasma gondii thioredoxin reductase 0.0041 0.0818 0.0492
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0104 0.2978 0.283
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0182 0.5663 0.5663
Schistosoma mansoni aldehyde dehydrogenase 0.0264 0.8451 0.8371
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 1 1
Mycobacterium tuberculosis Probable reductase 0.0094 0.262 0.2361
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0108 0.3123 0.3123
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1215 0.058
Brugia malayi Glycosyl hydrolases family 31 protein 0.0182 0.5663 0.8152
Loa Loa (eye worm) hypothetical protein 0.0148 0.448 0.448
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.1215 0.1438
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.1215 0.1438
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1215 0.058
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.1215 0.3892
Brugia malayi Pre-SET motif family protein 0.0032 0.0492 0.0708
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0422 0.1353
Trypanosoma brucei glucosidase, putative 0.004 0.0798 0.2556
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.1215 0.0761
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0798 0.0174
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0422 0.1353
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0384 0.0384
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0798 0.0322
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0492 0.0086
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.1215 0.1215
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0798 0.0798
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0836 0.0403
Mycobacterium ulcerans aldehyde dehydrogenase 0.0264 0.8451 1
Onchocerca volvulus 0.0106 0.3027 0.3382
Mycobacterium ulcerans aldehyde dehydrogenase 0.0264 0.8451 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0798 0.0174
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0094 0.262 0.2361
Plasmodium falciparum thioredoxin reductase 0.0041 0.0818 0.4984
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1215 0.0761
Schistosoma mansoni alpha-glucosidase 0.0157 0.4792 0.4523
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1067 0.1067
Brugia malayi hypothetical protein 0.0019 0.0064 0.0092
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.1215 0.1937
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 1 1
Brugia malayi Pre-SET motif family protein 0.022 0.6946 1
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.1215 0.3892
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.1215 0.3892
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.2978 0.283
Brugia malayi Thioredoxin reductase 0.0041 0.0818 0.1177
Loa Loa (eye worm) hypothetical protein 0.0107 0.3085 0.3085
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0798 0.0945
Loa Loa (eye worm) hypothetical protein 0.0148 0.448 0.448
Brugia malayi hypothetical protein 0.0148 0.448 0.645
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.1215 0.0799
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1067 0.0605
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.3123 1
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.1215 0.3892
Echinococcus granulosus lysosomal alpha glucosidase 0.0182 0.5663 0.5457
Leishmania major trypanothione reductase 0.0041 0.0818 0.0967
Echinococcus granulosus cyclin dependent kinase 0.0053 0.1215 0.0799
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0798 0.2556
Loa Loa (eye worm) hypothetical protein 0.003 0.0422 0.0422
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.1215 0.0799
Loa Loa (eye worm) hypothetical protein 0.0032 0.0492 0.0492
Entamoeba histolytica hypothetical protein 0.0108 0.3123 1
Brugia malayi glutathione reductase 0.0041 0.0818 0.1177
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0264 0.8451 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0798 0.1149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1067 0.0605
Schistosoma mansoni aldehyde dehydrogenase 0.0264 0.8451 0.8371
Echinococcus multilocularis lysosomal alpha glucosidase 0.0182 0.5663 0.5438
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.1215 0.1215
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0798 0.0363
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0264 0.8451 0.8378
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.1215 0.0761
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.1215 0.1215
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0104 0.2978 0.283
Loa Loa (eye worm) glutathione reductase 0.0041 0.0818 0.0818
Brugia malayi hypothetical protein 0.003 0.0422 0.0608
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0757 0.0279
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0264 0.8451 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0757 0.0279
Loa Loa (eye worm) hypothetical protein 0.0052 0.1177 0.1177
Plasmodium falciparum protein kinase 5 0.0053 0.1215 1
Plasmodium falciparum glutathione reductase 0.0041 0.0818 0.4984
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0798 0.2556
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1067 0.0605
Plasmodium vivax SET domain protein, putative 0.0032 0.0492 0.0875
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0094 0.262 0.2361
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.1215 0.0761
Brugia malayi hypothetical protein 0.0039 0.0757 0.109
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.6946 0.6946
Schistosoma mansoni alpha-glucosidase 0.0157 0.4792 0.4523

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibition of human recombinant GST-fusion DYRK1A expressed in Escherichia coli ChEMBL. 19615897
IC50 (binding) > 10 uM Inhibition of human recombinant CDK5/P25 by scintillation counting ChEMBL. 19615897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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