Detailed information for compound 106570

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 436.588 | Formula: C30H32N2O
  • H donors: 1 H acceptors: 1 LogP: 6.26 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1ccc(cc1)/C(=C/1\CC2CCC(C1)N2CCc1ccccc1)/c1ccccc1
  • InChi: 1S/C30H32N2O/c1-31-30(33)25-14-12-24(13-15-25)29(23-10-6-3-7-11-23)26-20-27-16-17-28(21-26)32(27)19-18-22-8-4-2-5-9-22/h2-15,27-28H,16-21H2,1H3,(H,31,33)
  • InChiKey: CSWHEDUISARBAD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PHD-finger family protein 0.0031 0.0247 0.0321
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0267 0.2984
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0924 0.1667
Echinococcus multilocularis geminin 0.0175 0.2591 0.2532
Echinococcus granulosus kinesin family 1 0.046 0.7217 0.7195
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0267 0.5
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0924 0.1667
Giardia lamblia PHD finger protein 15 0.0031 0.0247 0.1296
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0483 0.6388
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0247 0.0321
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.1689 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0289 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.138 0.808
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0267 0.2984
Onchocerca volvulus Alhambra homolog 0.0031 0.0247 0.003
Loa Loa (eye worm) acetyltransferase 0.0155 0.2265 0.2949
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0445 0.037
Loa Loa (eye worm) intermediate filament protein 0.003 0.0224 0.0292
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0798 0.0726
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0538 0.0745
Brugia malayi 6-phosphofructokinase 0.012 0.1689 0.22
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.029 0.0417
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1689 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.138 0.2565
Schistosoma mansoni lamin 0.003 0.0224 0.0237
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0267 0.1175
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.029 0.0417
Trypanosoma brucei polo-like protein kinase 0.0101 0.138 0.2565
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1689 0.2612
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0502 0.0835
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0798 0.2865
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.138 0.808
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0483 0.0408
Brugia malayi Bromodomain containing protein 0.0035 0.0309 0.0402
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0924 0.0853
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0924 0.5251
Brugia malayi jmjC domain containing protein 0.0038 0.0353 0.046
Brugia malayi isocitrate dehydrogenase 0.0034 0.029 0.0378
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.182 0.237
Giardia lamblia Kinase, PLK 0.0101 0.138 1
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0552 0.2943
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0538 0.0463
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0267 0.1175
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0502 0.0835
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0798 0.1419
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.029 0.0213
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.138 0.1797
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1689 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0483 0.2515
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.029 0.0417
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.138 0.211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0538 0.0745
Schistosoma mansoni hypothetical protein 0.0175 0.2591 0.4073
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0785 0.1023
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.1689 0.1624
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0798 0.0726
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.029 0.0417
Loa Loa (eye worm) hypothetical protein 0.0034 0.0289 0.0376
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0267 0.2984
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.2303 0.4383
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.2265 0.2949
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0798 0.1168
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0267 0.1175
Loa Loa (eye worm) hypothetical protein 0.0165 0.2418 0.3149
Schistosoma mansoni hypothetical protein 0.0175 0.2591 0.4073
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0924 0.1667
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0924 0.1667
Toxoplasma gondii hypothetical protein 0.0054 0.0614 0.7441
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.138 0.808
Schistosoma mansoni hypothetical protein 0.0034 0.0289 0.0342
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.029 0.294
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0333 0.5153 1
Schistosoma mansoni hypothetical protein 0.0073 0.0925 0.1373
Loa Loa (eye worm) hypothetical protein 0.0029 0.0216 0.0281
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.138 0.2565
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.1689 0.6408
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0483 0.2515
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0798 0.2865
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0267 0.2984
Echinococcus multilocularis GPCR, family 2 0.0034 0.0289 0.0213
Schistosoma mansoni hypothetical protein 0.0034 0.0289 0.0342
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0224 0.0292
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0078 0.0102
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.138 0.155
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0483 0.5625
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0289 0.0213
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0267 0.2627
Brugia malayi Isocitrate dehydrogenase 0.0034 0.029 0.0378
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1689 1
Loa Loa (eye worm) runx1 0.0061 0.0737 0.096
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0289 0.0376
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.029 0.3339
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0798 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0538 0.07
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0333 0.5153 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0421 0.2131
Entamoeba histolytica kinesin, putative 0.006 0.0712 0.3937
Echinococcus granulosus lamin 0.003 0.0224 0.0147
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0445 0.037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0502 0.0835
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0798 0.2865
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.182 0.237
Giardia lamblia Kinesin-5 0.006 0.0712 0.4872
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0267 0.5
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.138 0.1312
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1689 0.3174
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0483 0.5625
Loa Loa (eye worm) hypothetical protein 0.0165 0.2418 0.3149
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.138 0.1312
Echinococcus multilocularis peregrin 0.0035 0.0309 0.0232
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0798 0.1168
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.138 0.2565
Echinococcus multilocularis lamin 0.003 0.0224 0.0147
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.029 0.0842
Schistosoma mansoni hypothetical protein 0.0034 0.0289 0.0342
Echinococcus granulosus geminin 0.0175 0.2591 0.2532
Schistosoma mansoni kinase 0.0051 0.0574 0.0804
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.029 0.3339
Loa Loa (eye worm) phosphofructokinase 0.012 0.1689 0.22
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0924 0.1203
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0353 0.0446
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0353 0.0277
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0267 0.1175
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1689 0.3174
Echinococcus granulosus GPCR family 2 0.0034 0.0289 0.0213
Brugia malayi Muscleblind-like protein 0.0165 0.2418 0.3149
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0924 0.1372
Echinococcus granulosus lamin dm0 0.003 0.0224 0.0147
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0292
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.029 0.0213
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0289 0.0376
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0267 0.1175
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.029 0.0417
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0669 0.1163
Schistosoma mansoni hypothetical protein 0.0034 0.0289 0.0342
Plasmodium falciparum kinesin-5 0.006 0.0712 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0267 0.1454
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0289 0.0213
Loa Loa (eye worm) hypothetical protein 0.0166 0.2449 0.3189
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0924 0.1203
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0353 0.046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0538 0.0463
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.138 0.1797
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1689 1
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0267 0.2627
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0538 0.07
Leishmania major mitochondrial DNA polymerase beta 0.0333 0.5153 1
Echinococcus multilocularis musashi 0.003 0.0224 0.0147
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.2303 0.4383
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0224 0.0292
Mycobacterium tuberculosis Conserved hypothetical protein 0.0175 0.2592 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0289 0.0376
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.1689 0.5
Brugia malayi MH2 domain containing protein 0.0128 0.182 0.237
Brugia malayi hypothetical protein 0.0488 0.7679 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.138 0.808
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.029 0.0213
Loa Loa (eye worm) hypothetical protein 0.0106 0.1473 0.1918
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0925 0.1204
Plasmodium falciparum phd finger protein, putative 0.0031 0.0247 0.266
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0353 0.0446
Brugia malayi phosphofructokinase 0.012 0.1689 0.22
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.138 0.808
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.2265 0.2204
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.029 0.0378
Schistosoma mansoni jumonji domain containing protein 0.0081 0.1057 0.1587
Echinococcus multilocularis muscleblind protein 0.0165 0.2418 0.2358
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.2194 0.2133
Loa Loa (eye worm) hypothetical protein 0.0488 0.7679 1
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.1689 0.6408
Loa Loa (eye worm) hypothetical protein 0.0488 0.7679 1
Schistosoma mansoni hypothetical protein 0.04 0.6246 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0267 0.1175
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1689 1
Onchocerca volvulus 0.0488 0.7679 1
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.029 0.294
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0267 0.1175
Brugia malayi Kinesin motor domain containing protein 0.006 0.0712 0.0928
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0421 0.5413
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0538 0.0745
Plasmodium vivax kinesin-5 0.006 0.0712 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0925 0.1204
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0333 0.5153 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0078 0.0102
Echinococcus multilocularis lamin dm0 0.003 0.0224 0.0147
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0247 0.017
Echinococcus granulosus peregrin 0.0035 0.0309 0.0232
Mycobacterium ulcerans hypothetical protein 0.0175 0.2592 1
Schistosoma mansoni intermediate filament proteins 0.003 0.0224 0.0237
Loa Loa (eye worm) hypothetical protein 0.0031 0.0247 0.0321
Schistosoma mansoni lamin 0.003 0.0224 0.0237
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.1398 0.133
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.138 0.808
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0353 0.0277
Toxoplasma gondii kinesin motor domain-containing protein 0.006 0.0712 0.8805
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0552 0.2943
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0078 0.5
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0267 0.2627
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0247 0.0274
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0798 0.2865
Loa Loa (eye worm) kinesin-like protein KLP2 0.006 0.0712 0.0928
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.2265 0.3545
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0247 0.017
Echinococcus multilocularis Protein lozenge 0.0061 0.0737 0.0664
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0247 0.2342
Schistosoma mansoni lozenge 0.0061 0.0737 0.1068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.029 0.0213
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.2303 0.4383
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.138 0.808
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1689 0.2612
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0924 0.0853
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.029 0.0213
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0289 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.138 0.808
Schistosoma mansoni hypothetical protein 0.0031 0.0247 0.0274
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.1473 0.1918
Brugia malayi 6-phosphofructokinase 0.012 0.1689 0.22
Echinococcus granulosus muscleblind protein 0.0165 0.2418 0.2358
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.1398 0.133
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0247 0.2342
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0421 0.2638
Brugia malayi hypothetical protein 0.0166 0.2449 0.3189
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.029 0.0343
Echinococcus granulosus 6 phosphofructokinase 0.012 0.1689 0.1624
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1689 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0631 1 1
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0426 0.035
Brugia malayi jmjC domain containing protein 0.0102 0.1398 0.182
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1689 0.22
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0247 0.266
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0267 0.1175
Echinococcus multilocularis muscleblind protein 1 0.0165 0.2418 0.2358
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1689 0.22
Onchocerca volvulus 0.0166 0.2449 0.2984
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0502 0.0835
Loa Loa (eye worm) hypothetical protein 0.0053 0.0608 0.0792
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0538 0.0463
Echinococcus multilocularis kinesin family 1 0.046 0.7217 0.7195
Echinococcus granulosus intermediate filament protein 0.003 0.0224 0.0147
Brugia malayi intermediate filament protein 0.003 0.0224 0.0292
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0426 0.035
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.029 0.0213
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0538 0.0463
Schistosoma mansoni kinesin eg-5 0.006 0.0712 0.1028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.1473 0.1918
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0267 0.1175
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1689 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.1473 0.1918
Leishmania major ATP-dependent phosphofructokinase 0.012 0.1689 0.3174

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.14 nM In vitro binding affinity towards opioid receptor mu 1 ChEMBL. 15080990
Ki (binding) = 0.14 nM In vitro binding affinity towards opioid receptor mu 1 ChEMBL. 15080990
Ki (binding) = 13 nM In vitro binding affinity towards opioid receptor delta 1 ChEMBL. 15080990
Ki (binding) = 13 nM In vitro binding affinity towards opioid receptor delta 1 ChEMBL. 15080990
Selectivity (binding) = 0.011 Selectivity ratio of affinity at mu receptor versus delta opioid receptor ChEMBL. 15080990

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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